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951.
952.
Leonid V. Kurepin Wing-Kin Yip Rong Fan Edward C. Yeung David M. Reid 《Plant Growth Regulation》2010,61(3):215-222
Wild type (WT) tomato seedlings responded to a low red to far-red (R/FR) ratio with increased stem elongation, similar leaflet
area expansion and lower shoot ethylene levels. The levels of endogenous growth-active GA1 and its immediate precursor GA20 were decreased by low R/FR ratio, whereas the levels of GA1 catabolite, GA8, increased. To examine the interaction of ethylene with GAs in regulating tomato shoot growth under low R/FR ratio, transgenic
(T) seedlings bearing Le-ACS2 and Le-ACS4 antisense mRNA were utilized. Low R/FR ratio increased stem elongation and decreased ethylene levels in T tomato shoots,
as it did in WT shoots. However, T stems were significantly taller than the WT stems under low R/FR ratio. Leaflet areas were
significantly larger for T, than WT seedlings under both R/FR ratios. Low R/FR ratio did not decrease endogenous levels of
GA1 and GA20 in T shoots, but did increase GA8 levels, which were higher than in WT shoots. These results, and hormone/inhibitor application studies, showed that in tomato
shoots subjected to low R/FR ratio, GAs play a growth-promotive role in stem elongation, whereas ethylene is growth-inhibitory.
Further, these results may imply that decreasing ethylene production under low R/FR ratio causes increases in stem elongation
and GA levels. 相似文献
953.
Mark Reid Ian Carlyle Wilson L. Caulfield Tom R. Clarkson Fiona Cusick Ola Epemolu Robert Gilfillan Richard Goodwin David Jaap Elise C. O’Donnell Jeremy Presland Zoran Rankovic Daniel Spinks Gayle Spinks Anne M. Thomson Fiona Thomson James Strain Grant Wishart 《Bioorganic & medicinal chemistry letters》2010,20(12):3713-3716
Antagonists of the 5-HT6 receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as Alzheimer’s disease (AD) and schizophrenia. We report herein the identification and SAR around N-(2-aminoalkyl)-1-(arylsulfonyl)indoline-3-carboxamides—a novel chemotype of 5-HT6 antagonists. 相似文献
954.
955.
Ubydul Haque Ricardo J Soares Magalhães Heidi L Reid Archie CA Clements Syed Masud Ahmed Akramul Islam Taro Yamamoto Rashidul Haque Gregory E Glass 《Malaria journal》2010,9(1):120
Background
Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%).Methods
A risk map was developed and geographic risk factors identified using a Bayesian approach. The Bayesian geostatistical model was developed from previously identified individual and environmental covariates (p < 0.2; age, different forest types, elevation and economic status) for malaria prevalence using WinBUGS 1.4. Spatial correlation was estimated within a Bayesian framework based on a geostatistical model. The infection status (positives and negatives) was modeled using a Bernoulli distribution. Maps of the posterior distributions of predicted prevalence were developed in geographic information system (GIS).Results
Predicted high prevalence areas were located along the north-eastern areas, and central part of the study area. Low to moderate prevalence areas were predicted in the southwestern, southeastern and central regions. Individual age and nearness to fragmented forest were associated with malaria prevalence after adjusting the spatial auto-correlation.Conclusion
A Bayesian analytical approach using multiple enabling technologies (geographic information systems, global positioning systems, and remote sensing) provide a strategy to characterize spatial heterogeneity in malaria risk at a fine scale. Even in the most hyper endemic region of Bangladesh there is substantial spatial heterogeneity in risk. Areas that are predicted to be at high risk, based on the environment but that have not been reached by surveys are identified.956.
Restoration of ecological communities that can withstand future climate and land use changes requires information on species responses to various natural disturbances. Frost is an important disturbance that regulates plant species distributions, and although rare in tropical rainforest, it can occur in upland areas, especially where deforestation has occurred. We report the impacts of a severe frost that occurred in June and July 2007 on the Atherton Tablelands, Queensland, Australia and caused extensive damage to riparian restoration plots of upland rainforest species. We estimated proportion foliage retention to (1) compare impacts across 45 species; (2) examine the influence of plant height on frost effects; and (3) determine if plantings under shelterbelts of mature trees received less damage. Species exhibited different levels of foliage retention. Species that were particularly frost resistant included those from riparian habitats and a conifer. Some heavily impacted species are deciduous and may survive frost by shedding leaves; this warrants further investigation. Plant canopy height above ground level was only weakly correlated to foliage retention. Sheltered plants were much less damaged than unsheltered conspecifics, suggesting a useful way to mitigate frost impacts. These principles should help guide the development of resilient ecological communities in frost‐prone areas. 相似文献
957.
The body shape of fishes encompasses a number of morphological traits that are intrinsically linked to functional systems and affect various measures of performance, including swimming, feeding, and avoiding predators. Changes in shape can allow a species to exploit a new ecological niche and can lead to ecological speciation. Body shape results from the integration of morphological, behavioral and physiological traits. It has been well established that functional interdependency among traits plays a large role in constraining the evolution of shape, affecting both the speed and the repeated evolution of particular body shapes. However, it is less clear what role genetic or developmental constraints might play in biasing the rate or direction of the evolution of body shape. Here, we suggest that the threespine stickleback (Gasterosteus aculeatus) is a powerful model system in which to address the extent to which genetic or developmental constraints play a role in the evolution of body shape in fishes. We review the existing data that begins to address these issues in sticklebacks and provide suggestions for future areas of research that will be particularly fruitful for illuminating the mechanisms that contribute to the evolution of body shape in fishes. 相似文献
958.
959.
Long-term maternal effect on offspring immune response in song sparrows Melospiza melodia 总被引:1,自引:0,他引:1
Knowledge of the causes of variation in host immunity to parasitic infection and the time-scales over which variation persists, is integral to predicting the evolutionary and epidemiological consequences of host-parasite interactions. It is clear that offspring immunity can be influenced by parental immune experience, for example, reflecting transfer of antibodies from mothers to young offspring. However, it is less clear whether such parental effects persist or have functional consequences over longer time-scales, linking a parent's previous immune experience to future immune responsiveness in fully grown offspring. We used free-living song sparrows (Melospiza melodia) to quantify long-term effects of parental immune experience on offspring immune response. We experimentally vaccinated parents with a novel antigen and tested whether parental vaccination influenced the humoral antibody response mounted by fully grown offspring hatched the following year. Parental vaccination did not influence offspring baseline antibody titres. However, offspring of vaccinated mothers mounted substantially stronger antibody responses than offspring of unvaccinated mothers. Antibody responses did not differ between offspring of vaccinated and unvaccinated fathers. These data demonstrate substantial long-term effects of maternal immune experience on the humoral immune response of fully grown offspring in free-living birds. 相似文献