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241.
242.
Ceara J. Talbot Elena M. Bennett Kelsie Cassell Daniel M. Hanes Elizabeth C. Minor Hans Paerl Peter A. Raymond Rodrigo Vargas Philippe G. Vidon Wilfred Wollheim Marguerite A. Xenopoulos 《Biogeochemistry》2018,141(3):439-461
Flooding is a major disturbance that impacts aquatic ecosystems and the ecosystem services that they provide. Predicted increases in global flood risk due to land use change and water cycle intensification will likely only increase the frequency and severity of these impacts. Extreme flooding events can cause loss of life and significant destruction to property and infrastructure, effects that are easily recognized and frequently reported in the media. However, flooding also has many other effects on people through freshwater aquatic ecosystem services, which often go unrecognized because they are less evident and can be difficult to evaluate. Here, we identify the effects that small magnitude frequently occurring floods (<?10-year recurrence interval) and extreme floods (>?100-year recurrence interval) have on ten aquatic ecosystem services through a systematic literature review. We focused on ecosystem services considered by the Millennium Ecosystem Assessment including: (1) supporting services (primary production, soil formation), (2) regulating services (water regulation, water quality, disease regulation, climate regulation), (3) provisioning services (drinking water, food supply), and (4) cultural services (aesthetic value, recreation and tourism). The literature search resulted in 117 studies and each of the ten ecosystem services was represented by an average of 12?±?4 studies. Extreme floods resulted in losses in almost every ecosystem service considered in this study. However, small floods had neutral or positive effects on half of the ecosystem services we considered. For example, small floods led to increases in primary production, water regulation, and recreation and tourism. Decision-making that preserves small floods while reducing the impacts of extreme floods can increase ecosystem service provision and minimize losses. 相似文献
243.
H. J. Thomas S. C. Whitelaw S. E. Cottrell V. A. Murday I. P. Tomlinson D. Markie T. Jones D. T. Bishop S. V. Hodgson D. Sheer J. M. Northover I. C. Talbot E. Solomon W. F. Bodmer 《American journal of human genetics》1996,58(4):770-776
Hereditary mixed polyposis syndrome (HMPS) is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. HMPS appears to be inherited in an autosomal dominant manner. Genetic linkage analysis has been performed on a large family with HMPS. Data did not support linkage to the APC locus or to any of the loci for hereditary nonpolyposis colorectal cancer. Evidence that the HMPS locus lies on chromosome 6q was, however, provided by significant two-point LOD scores for linkage between HMPS and the D6S283 locus. Analysis of recombinants and multipoint linkage analysis suggested that the HMPS locus lies in a 4-cM interval containing the D6S283 locus and flanked by markers D6S468 and D6S301. 相似文献
244.
Ted R. Schultz Reginald B. Cocroft Gary A. Churchill 《Evolution; international journal of organic evolution》1996,50(2):504-511
The problem of error in the phylogenetic reconstruction of ancestral character states is explored by developing the model of Frumhoff and Reeve (1994). Information about the evolutionary rate of change within a character is inferred from the distribution of its character states on a known phylogeny, and this information is used to impose confidence limits on the error associated with ancestral state inference. Ancestral state inference is found to be remarkably robust under the model assumptions for a wide range of parameter values; however, the probability of error increases when the number of species within a clade is small and/or state-transition probabilities are strongly skewed in favor of the non-ancestral state. The rationale for expecting such a skew, a hypothesis of parallelism, is shown to rely on assumptions of low rates of change in at least two phylogenetically inherited characters: the tendency to occupy a particular ecological niche and the tendency to respond in a particular way to selection. A means for judging the relative likelihoods of parallelism vs. straightforward homology as explanations for a given character-state distribution is suggested. General problems with the model are discussed, as are methods for making it more realistic. 相似文献
245.
The solubility behaviour of praziquantel enantiomeric system at ?15°C, 4°C, and 15°C is presented. This system exhibits both a pseudoracemate behaviour and one which leads to the formation of enantiomerically pure crystals. For solutions with lower enantiomeric purity, the pseudoracemate behaviour is more prominent. Solid solutions are formed when the mixtures of the enantiomers are crystallised. The phase diagram shows a complete absence of a eutetic. For mixtures with higher enantiomeric purity, pure crystals of the excess enantiomer are obtained when the solution is crystallised. Temperature dependency of this polymorphism is not significant. With these phase diagrams, a method is suggested to obtain enantiomerically pure isomers of praziquantel from a partially resolved mixture. © 1995 Wiley-Liss, Inc. 相似文献
246.
Jasna Bingulac-Popovic F. Figueroa Akie Sato William S. Talbot Stephen L. Johnson Michael Gates J. H. Postlethwait Jan Klein 《Immunogenetics》1997,46(2):129-134
The mammalian major histocompatibility complex (Mhc) consists of three closely linked regions, I, II, and III, occupying a single chromosomal segment. The class I loci in region
I and the class II loci in region II are related in their structure, function, and evolution. Region III, which is intercalated
between regions I and II, contains loci unrelated to the class I and II loci, and to one another. There are indications that
a similar Mhc organization exists in birds and amphibians. Here, we demonstrate that in the zebrafish (Danio rerio), a representative of the teleost fishes, the class II loci are divided between two linkage groups which are distinct from
the linkage group containing the class I loci. The β2-microglobulin-encoding gene is loosely linked to one of the class II loci. The gene coding for complement factor B, which
is one of the region III genes in mammals, is linked neither to the class I nor to the class II loci in the zebrafish. These
results, combined with preliminary data suggesting that the class I and class II regions in another order of teleost fish
are also in different linkage groups, indicate that close linkage of the two regions is not necessary either for regulation
of expression or for co-evolution of the class I and class II loci. They also raise the question of whether linkage of the
class I and class II loci in tetrapods is a primitive or derived character.
Received: 16 December 1996 / Revised: 6 February 1997 相似文献
247.
Richard Blouin Gilles Grondin Jude Beaudoin Yoshi Arita Nathalie Daigle Brian G. Talbot Denis Lebel Jean Morisset 《In vitro cellular & developmental biology. Animal》1997,33(9):717-726
Summary This study describes the establishment and characterization of an immortalized cell line derived from the pancreas of an adult
H-2Kb-tsA58 transgenic mouse. These cells, designated IMPAN for IMmortalized PANcreatic cells, displayed a cobblestone appearance
typical of confluent epithelial cells and a distinct polarity in the organization of their cytoplasmic organelles. Immunocytochemical
studies revealed that all IMPAN cells stained positively for a wide range of markers characteristic of pancreatic acinar cells,
namely the secretory products α-amylase, chymotrypsinogen, DNAse, the lectinlike secretory protein PAP (pancreatitis associated
protein), and the zymogen granule membrane proteins GP-2 and gp300. They also stained positively for carbonic anhydrase II
and cytokeratin 19, two proteins characteristic of pancreatic duct cells, as well as for rab3A, a small GTP-binding protein
specifically localized in pancreatic islet cells. No reactivity was ever obtained with insulin antibodies. Taken together,
these results show that the IMPAN cells exhibit a phenotype comparable to exocrine pancreatic acinar cells. However the expression
of some proteins more specific to duct and islet cells make them similar to in vivo or in vitro growing acinar cells. The cell line should be a valuable model to study the mechanisms of growth, differentiation, and transformation
of the exocrine pancreatic acinar cell. 相似文献
248.
249.
Reginald F. Frye Dwight D. Stiff 《Journal of chromatography. B, Analytical technologies in the biomedical and life sciences》1996,686(2):5281
A sensitive and reproducible method is described for the determination of the cytochrome P450 enzyme 2E1 substrate chlorzoxazone and its primary metabolite 6-hydroxychlorzoxazone in human plasma and urine. Plasma or diluted urine were acidified, incubated with β-glucuronidase and then were extracted with diethyl ether. Separation of the analytes was achieved on a C18 column with UV detection set at 283 nm. Excellent linearity was observed over the concentration ranges of 100–3000 ng/ml and 4–400 μg/ml in plasma and urine, respectively. The intra-assay variability was 5.1% and the inter-assay variability was 8.2% for each compound in each matrix. The method presented is applicable to pharmacokinetic and pharmacogenetic studies utilizing chlorzoxazone. 相似文献
250.
A parentage evaluation test in North American Elk (Wapiti) using microsatellites of ovine and bovine origin 总被引:6,自引:0,他引:6
DNA microsatellites originally detected in sheep and cattle are also detectable in North American elk (Wapiti) using polymerase chain reactions. We have developed a parentage test in elk using eleven microsatellite markers that are highly polymorphic and informative. 相似文献