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Abdulaziz A Al-Askar Khalid M Ghoneem Younes M Rashad Waleed M Abdulkhair Elsayed E Hafez Yasser M Shabana Zakaria A Baka 《Microbial biotechnology》2014,7(6):556-569
One hundred samples of tomato seeds were collected in 2011 and 2012 from tomato-cultivated fields in Saudi Arabia and screened for their seed-borne mycoflora. A total of 30 genera and 57 species of fungi were recovered from the collected seed samples using agar plate and deep-freezing blotter methods. The two methods differed as regards the frequency of recovered seed-borne fungi. Seven fungi among those recovered from tomato seeds, which are known as plant pathogens, were tested for their pathogenicity and transmission on tomato seedlings. The recovery rate of these pathogens gradually decreased from root up to the upper stem, and did not reach to the stem apex. The distribution of tomato seed-borne fungi was also investigated throughout Saudi Arabia. In this concern, Al-Madena governorate recorded the highest incidence of fungal flora associated with tomato seeds. The impact of meteorological variables on the distribution of tomato seed-borne mycoflora was explored using the ordination technique (canonical correspondence analysis). Among all climatic factors, relative humidity was the most influential variable in this regard. Our findings may provide a valuable contribution to our understanding of future global disease change and may be used also to predict disease occurrence and fungal transfer to new uninfected areas. 相似文献
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Alaa A.-M. Abdel-Aziz Adel S. El-Azab Nawaf A. AlSaif Mohammed M. Alanazi Manal A. El-Gendy Ahmad J. Obaidullah 《Journal of enzyme inhibition and medicinal chemistry》2013,28(1):610-621
Abstract Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory agents were subjected to in vitro COX-1/2 inhibition assay. 3-Benzenesulfonamides (2–4, and 9), oximes (11–13), and β-phenylalanine derivative (18) showed potential anti-inflammatory activities with 71.2–82.9% oedema inhibition relative to celecoxib and diclofenac (85.6 and 83.4%, respectively). Most active cyclic imides 4, 9, 12, 13, and 18 possessed ED50 of 35.4–45.3?mg kg?1 relative to that of celecoxib (34.1?mg kg?1). For the cytotoxic evaluation, the selected derivatives 2–6 and 8 exhibited weak positive cytotoxic effects (PCE = 2/59–5/59) at 10?μM compared to the standard drug, imatinib (PCE = 20/59). Cyclic imides bearing 3-benzenesulfonamide (2–5, and 9), acetophenone oxime (11–14, 18, and 19) exhibited high selectivity against COX-2 with SI > 55.6–333.3 relative to that for celecoxib [SI > 387.6]. β-Phenylalanine derivatives 21–24 and 28 were non-selective towards COX-1/2 isozymes as indicated by their SI of 0.46–0.68. 相似文献
105.
Adel S. El-Azab Alaa A.-M. Abdel-Aziz Hany E. A. Ahmed Sivia Bua Alessio Nocentini Nawaf A. AlSaif 《Journal of enzyme inhibition and medicinal chemistry》2013,28(1):598-609
Abstract Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficiently inhibited by compounds 2–13 with inhibition constants (KIs) ranging from 57.8–740.2?nM. Compounds 2, 3, 4, and 12 showed inhibitory action against hCA II with KIs between 6.4 and 14.2?nM. CA IX exhibited significant sensitivity to inhibition by derivatives 2–13 with KI values ranging from 7.1 to 93.6?nM. Compounds 2, 3, 4, 8, 9, and 12 also exerted potent inhibitory action against hCA XII (KIs ranging from 3.1 to 20.2?nM). Molecular docking studies for the most potent compounds 2 and 3 were conducted to exhibit the binding mode towards hCA isoforms as a promising step for SAR analyses which showed similar interaction with co-crystallized ligands. As such, a subset of these mercaptoquinazolin-4(3H)-one compounds represented interesting leads for developing new efficient and selective carbonic anhydrase inhibitors (CAIs) for the management of a variety of diseases including glaucoma, epilepsy, arthritis and cancer. 相似文献
106.
Habib Noman Ali Qasim Ali Shafaqat Haider Muhammad Zulqarnain Javed Muhammad Tariq Khalid Mubashra Perveen Rashida Alsahli Abdulaziz Abdullah Alyemeni Mohammed Nasser 《Journal of Plant Growth Regulation》2021,40(6):2433-2453
Journal of Plant Growth Regulation - To mitigate the deleterious effects of abiotic stresses signaling molecules play a significant role. The present study was aimed to assess the responses of two... 相似文献
107.
Tarique Mohammed Ahmad Shaban Malik Arshi Ahmad Irfan Saeed Mohd Almatroudi Ahmad Qadah Talal Murad Manal Abdulaziz Mashraqi Mutaib Alam Qamre Al-Saleh Yousef 《Molecular and cellular biochemistry》2021,476(5):2203-2217
Molecular and Cellular Biochemistry - Novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) causes mild to severe respiratory illness. The early symptoms may be fever, dry... 相似文献
108.
Shilpa Bhandi Ahmed Al Khatani Hassan Abdulaziz Sumayli Mushyirah Yahya Sabyei Abdulaziz Mohammed Al Zailai Mohammed Ali Sumayli Hanan Ibrahim Hakami Mohammed Abdurabu Jafer Nishant Vyas Hosam Ali Baeshen Luca Testarelli Shankargouda Patil 《Saudi Journal of Biological Sciences》2021,28(6):3559-3565
ObjectivesTo compare and analyze the secretome profile of stem cells obtained from the deciduous tooth (SHEDs), young (yDPSCs), and old permanent tooth (oDPSCs).MethodsAll the stem cells were assessed for mesenchymal stem cell markers. The stem cells were differentiated into osteoblasts and chondrocytes using lineage-specific differentiation media. Conditioned media was collected from growing stem cells, and a cytometric bead array was performed to estimate secreted cytokines and growth factor levels by flow cytometry. Gene expresseion levels were assessed by real-time quantitative polymerase chain reaction.ResultsAge did not affect the mesenchymal characteristics of dental stem cells from various age groups. The secretomes of SHEDs and young yDPSCs exhibit more growth factors and lesser pro-inflammatory cytokines than oDPSCs. Osteo and chondrogenic differentiation potential were higher in SHEDs and young yDPSCs than in the oDPSCs. TLR1, TLR2, TLR3 show decreased expression levels with age and TLR5, TLR6 show increased expression with age.ConclusionThe superior regenerative potential of SHEDs and yDPSCs may be due to the higher growth factors and lower pro-inflammatory cytokine profile. 相似文献
109.
Abdulaziz Alodhayani Khalid M. Almutairi Jason M. Vinluan Turky H. Almigbal Wadi B. Alonazi Mohammed Ali Batais Muhanna Mohammed Alnassar 《Saudi Journal of Biological Sciences》2021,28(4):2460-2465
ObjectiveIn this cross-sectional study, we aimed to determine the association of self-care management practices and glycemic control of type 2 diabetes mellitus in Saudi Arabia.MethodsA total of 352 type 2 diabetes mellitus (T2DM) patients from two public tertiary hospitals in Saudi Arabia participated in this study. All T2DM patients were recruited and interviewed by a researcher between January to April 2018 from the outpatient diabetes clinics. All respondents answered a four-part questionnaire which includes demographics data, Diabetes Self-Management Questionnaire (DSMQ). Linear Regression was performed to assess the significance of predictors and compute the coefficient of determination.ResultsThe mean age of the participants was 51.89 ± 10.94. Of the 352 participants, 52% were obese (BMI: ≥30 kgm2) and 77% of the participants had glycated haemoglobin (HbA1c) over 7%. The analysis showed that subscale of Glucose management was the strongest predictor of Hba1c levels of participants’ followed by physical activity. Gender and marital status emerged as significant predictors for their self-care management practices. Female patients had more self-care management practices than male patients (B 0.20; 95CI 0.10– 0.96 (p = 0.015).ConclusionThis study provides an evidence on the self-care management of T2DM patients in Saudi Arabia. The high self-care management found in the study highlights that the patients are aware of the severity of and possible complications associated with T2DM. 相似文献
110.
Agarwal Garima Gabrani Reema 《International journal of peptide research and therapeutics》2021,27(1):149-168
International Journal of Peptide Research and Therapeutics - Despite rapid advances in the human healthcare, the infection caused by certain viruses results in high morbidity and mortality... 相似文献