全文获取类型
收费全文 | 600篇 |
免费 | 55篇 |
出版年
2021年 | 2篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 9篇 |
2015年 | 20篇 |
2014年 | 22篇 |
2013年 | 32篇 |
2012年 | 27篇 |
2011年 | 25篇 |
2010年 | 30篇 |
2009年 | 33篇 |
2008年 | 21篇 |
2007年 | 26篇 |
2006年 | 23篇 |
2005年 | 26篇 |
2004年 | 25篇 |
2003年 | 22篇 |
2002年 | 14篇 |
2001年 | 18篇 |
2000年 | 18篇 |
1999年 | 12篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 7篇 |
1995年 | 13篇 |
1994年 | 8篇 |
1993年 | 14篇 |
1992年 | 8篇 |
1991年 | 14篇 |
1990年 | 8篇 |
1989年 | 10篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 7篇 |
1985年 | 12篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 17篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1950年 | 2篇 |
排序方式: 共有655条查询结果,搜索用时 331 毫秒
91.
92.
93.
The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' → 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex. 相似文献
94.
Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. 总被引:4,自引:0,他引:4
Helen F Boyd Stephen C M Fell Deirdre M B Hickey Robert J Ife Colin A Leach Colin H Macphee Kevin J Milliner Ivan L Pinto D Anthony Rawlings Stephen A Smith Ian G Stansfield Steven J Stanway Colin J Theobald Caroline M Whittaker 《Bioorganic & medicinal chemistry letters》2002,12(1):51-55
A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with high potency in whole human plasma. 5-(Pyrazolylmethyl) derivative 16 and 5-(methoxypyrimidinylmethyl) derivative 27 demonstrated excellent pharmacodynamic profiles which correlated well with their pharmacokinetic effects. 相似文献
95.
96.
97.
D C Speckhard W B Knight J Rawlings W W Cleland 《Journal of inorganic biochemistry》1989,36(2):99-106
Cobalt(III)H2O(NH3)3 pyrophosphate has been shown by proton and 31P nuclear magnetic resonance (NMR) to be a facial bidentate complex. Cobalt(III)H2O(NH3)3 adenosine diphosphate has been resolved into lambda and delta isomers by chromatography on cycloheptaamylose. Both the lambda and delta forms are a pair of isomers that are not separated by cycloheptaamylose, reverse phase high-pressure liquid chromatography (HPLC), or cation exchange chromatography. These isomers presumably represent syn- and anti-arrangement of coordinated water and adenosine. 相似文献
98.
99.
100.
ABSTRACTSleep deprivation impairs performance on cognitive tasks, but it is unclear which cognitive processes it degrades. We administered a semantic matching task with variable stimulus onset asynchrony (SOA) and both speeded and self-paced trial blocks. The task was administered at the baseline and 24 hours later after 30.8 hours of total sleep deprivation (TSD) or matching well-rested control. After sleep deprivation, the 20% slowest response times (RTs) were significantly increased. However, the semantic encoding time component of the RTs remained at baseline level. Thus, the performance impairment induced by sleep deprivation on this task occurred in cognitive processes downstream of semantic encoding. 相似文献