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排序方式: 共有175条查询结果,搜索用时 15 毫秒
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Reynolds JN Bennett BM Boegman RJ Jhamandas K Ratz JD Zavorin SI Scutaru D Dumitrascu A Thatcher GR 《Bioorganic & medicinal chemistry letters》2002,12(20):2863-2866
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia. 相似文献
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Elanor Miller Chris Lalas Steve Dawson Hiltrun Ratz Elisabeth Slooten 《Marine Mammal Science》2013,29(4):606-628
Stomach contents of 63 Hector's dolphins (Cephalorhynchus hectori) were collected between 1984 and 2006 from throughout New Zealand to provide the first quantitative assessment of prey composition. Twenty‐nine taxa were identified. Those most commonly consumed were red cod (Pseudophycis bachus), ahuru (Auchenoceros punctatus), arrow squid (Nototodarus sp.), sprat (Sprattus sp.), sole (Peltorhamphus sp.), and stargazer (Crapatalus sp.). By mass, these six species contributed 77% of total diet. Red cod contributed the most in terms of mass (37%), while ahuru and Hector's lanternfish (Lampanyctodes hectoris) were consumed in large numbers. Prey ranged from <1 cm to >60 cm in total length, but the majority of prey items were <10 cm long, indicating that for some species, juveniles were targeted. Diets of dolphins from South Island east and west coasts were significantly different, due largely to javelinfish (Lepidorhynchus denticulatus) being of greater importance in west coast stomachs, and a greater consumption of demersal prey species in the east. The feeding ecology of Hector's dolphin is broadly similar to that of other Cephalorhynchus species. Hector's dolphin is shown to feed on species from throughout the water column, and differences in diet between populations are thought to reflect prey availability. 相似文献
106.
Sophie Lèbre Jennifer Becq Frédéric Devaux Michael PH Stumpf Gaëlle Lelandais 《BMC systems biology》2010,4(1):130
Background
Biological networks are highly dynamic in response to environmental and physiological cues. This variability is in contrast to conventional analyses of biological networks, which have overwhelmingly employed static graph models which stay constant over time to describe biological systems and their underlying molecular interactions. 相似文献107.
Call C Han S Speich JE Eddinger TJ Ratz PH 《American journal of physiology. Heart and circulatory physiology》2006,291(4):H1513-H1520
We recently determined that the ability of the femoral artery (FA) to maintain higher levels of tonic isometric stress compared with the saphenous artery (SA) was due to differential expression of motor proteins permitting latch-bridge formation in FA and not SA. Arteries under pressure in vivo are not constrained to contract isometrically. Thus the significance of latch-bridge formation in arterial physiology remains to be determined. To address this translational question, diameter changes of pressurized FA and SA were compared. The reduction in lumen diameter induced by KCl at 80 mmHg (isobaric active constriction; IAC) was greater at 30 s than 10 min in SA. In FA, the reverse was true, mimicking isometric contractile responses identified in our earlier work. From 80 to 150 mmHg, the %IAC induced by KCl was greater in SA than FA (e.g., approximately 80% vs. approximately 30% at 120 mmHg). This was not explained by differences in contractile mechanisms but was likely due to differences in absolute artery diameters. In constricted arteries subjected to a ramp increase in pressure from 60 to 120 mmHg, the constricted diameter of FA, but not SA, was greater than the IAC diameter at each pressure. Thus FA but not SA could maintain a smaller diameter on being pressurized when first constricted than it could achieve by isobaric constriction. These data support the hypothesis that latch bridges permit constricted large-diameter elastic arteries such as the FA to temporarily resist dilatation in the face of transient increases in blood pressures. 相似文献
108.
Ratz PH Miner AS 《American journal of physiology. Regulatory, integrative and comparative physiology》2003,284(4):R1063-R1070
Urinary bladder (detrusor) smooth muscle is active in the absence of an external stimulus. Tone occurs even "at rest" during the filling phase, and it is elevated in patients with overactive bladder. This study examined the role of muscle length on tone and the level of basal myosin light chain phosphorylation (MLC(20P)). MLC(20P) was 23.9 +/- 1% (n = 58) at short lengths (zero preload; L(z)). An increase in length from L(z) to the optimal length for contraction (L(o)) caused a reduction in MLC(20P) to 15.8 +/- 1% (n = 49). Whereas 10 microM staurosporine reduced MLC(20P) at L(z), 1 microM staurosporine, a Ca(2+)-free solution, and inhibitors of MLC kinase, protein kinase C (PKC) and RhoA kinase (ROK) did not. However, 1 microM staurosporine and inhibitors of ROK inhibited MLC(20P) and tone at L(o). These data support the hypothesis that a Ca(2+)-independent kinase, possibly ZIP-like kinase, regulates MLC(20P) at L(z), whereas in detrusor stretched to L(o), additional kinases, such as ROK, participate. 相似文献
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Comprehensive, human cellular protein databases and their implication for the study of genome organization and function 总被引:2,自引:0,他引:2
J E Celis G P Ratz P Madsen B Gesser J B Lauridsen S Kwee H H Rasmussen H V Nielsen D Crüger B Basse 《FEBS letters》1989,244(2):247-254
Comprehensive, computerized databases of cellular protein information derived from the analysis of two-dimensional gels, together with recently developed techniques to microsequence proteins offer a new dimension to the study of genome organization and function. In particular, human protein databases provide an ideal framework in which to focus the human genome sequencing effort. 相似文献