耐低温产甲烷菌的分离及其产气活性的初探

在青藏高原地区的低温条件下通过滚管技术分离了一类耐低温产甲烷菌,并利用气相色谱法测定了产气活性。结果表明:这类甲烷菌最低产气温度为8℃,甲烷气体产生的高峰期在厌氧培养的第7 d;pH值与盐浓度对其产气活性均有影响,最佳条件为pH值7.0、盐度4%。     

冷蒿草原土壤可萌发种子库特征及其对放牧的响应

（１）采用萌发试验法对内蒙古冷蒿（Ａｒｔｅｍｉｓｉａ ｆｒｉｇｉｄａ）草原土壤种子特征及其在不同放牧压力下的变化进行了研究。（２）冷蒿草原可萌发种子库由４种多年生禾草,１１种种多年生杂草及３种１年生植物所组成。（３）每样中的可萌发种子是变化于４５到３０５之间,平均１０２／样。多年生禾草、多年生杂类草及１年生植物的土壤中种子量分别占总可萌发种子库的４６．５７％、５１．９６％和１．５７％。多年和禾 草     

Bilateral detection thresholds in dextrals and sinistrals reflect the more sensitive side of the nose, which is not lateralized [published erratum appears in Chem Senses 1998 Dec;23(6):761]

Several fundamental questions remain enigmatic concerning human olfactory sensitivity, including (i) whether detection threshold differences exist between the two sides of the nose (and, if so, whether such differences are influenced by handedness) and (ii) whether bilateral (i.e. binasal) stimulation leads to lower thresholds than unilateral stimulation (and, if so, whether the degree of facilitation is inversely related to general olfactory ability). In this study, and well-validated single staircase procedure was used to establish bilateral and unilateral detection thresholds for the cranial nerve I stimulant phenyl ethyl alcohol in 130 right- and 33 left-handed subjects. No differences in sensitivity between the left and right sides of the nose were observed in either group. Bilateral thresholds were lower, on average, than unilateral thresholds when the latter were categorized in terms of left and right nares. However, the bilateral thresholds did not differ significantly from those of the side of the nose with the lower threshold. Overall smell ability, as measured by the University of Pennsylvania Smell Identification Test, did not interact with any of the test measures. These data imply that (i) the left and right sides of the nose do not systematically differ in detection threshold sensitivity for either dextrals or sinistrals and (ii) if central integration of left:right olfactory threshold sensitivity occurs, its effects do not exceed the function of the better side of the nose.      

云南瓶尔小草属一新种

Ophioglossum yongrenense Ching ex Z. R. He et W. M. Chu, sp. nov.Species nova aspectu inter O. kawamuram Tagawa et O. parvum Nishida et Kurita Japonicae, differt a priore frondibus pro parte laminis sterilibus praeditis (in illa frondibus omnino laminis sterilibus non praeditis), a posteriore frondibus pro parte laminis sterilibus non praeditis (in O. parvo Nishida et Kurita frondibus omino laminis sterilibus praeditis).……     

Polypharmacy in the management of patients with schizophrenia on risperidone in a tertiary-care hospital in Malaysia

The present study was conducted primarily to determine the occurrence of polypharmacy in patients with schizophrenia on risperidone. The secondary aim was to ascertain the incidence of inappropriate prescribing with anticholinergics. A retrospective review of the medical records of all patients who were being followed up at the out-patient clinic of a tertiary-care hospital in Malaysia was conducted. Only patients who were being prescribed risperidone between 1 June 2008 and 31 December 2008 were included in the study. Demographic data such as patient’s age, gender and race were obtained from the patient’s medical records. In total, 113 patients met the selection criteria. Polypharmacy was found to occur in 34 patients (30.09%), with the majority (76.47%) being on two antipsychotics. In total, 27 patients (34.18%) on monotherapy with risperidone were prescribed an anticholinergic on scheduled dosing, while 19 patients (24.05%) were prescribed it on an as-needed basis. Of the patients on polypharmacy, 26 (76.47%) were on scheduled dosing of anticholinergics, while three (8.82%) were taking the medication on an as-needed basis. Polypharmacy should be avoided, and the use of anticholinergics should be closely reviewed. By adopting more efficient prescribing practices, costs can be reduced and financial resources can instead be channelled towards more beneficial areas for the patients.     

Investigation on the Anticancer and Antibacterial Mechanism of Thiazoline/Imidazoline Derived Palladium(II) Complexes

Biological activities of a series of palladium(II) complexes (M1–M9) bearing N^∩N, N^∩S, and N^∩O chelating ligands are reported. The palladium complexes were tested for their cytotoxic properties against human cervical cancer (HeLa) cells and antibacterial activity against Gm^+ve and Gm^–ve bacteria. Among the palladium complexes studied (M1-M9), the complex M5, M8, and M9 were found to be more effective in inhibiting the proliferation of HeLa cells. Hence, these complexes were further investigated for their potential role in cellular damage and apoptosis. DCFDA staining, Rhodamine 123 staining and DNA cleavage assay revealed that complex M5, M8 and M9 induced apoptotic cell death in HeLa cells through ROS generation, DNA damage and mitochondrial depolarization. Computational and titration studies also indicated strong electrostatic interaction with DNA groove. Most of the complexes exhibited good antibacterial activity against both Gm^+ve and Gm^−ve bacteria. The antibacterial activity of the compounds could not be correlated with their anticancer activity indicating a differential mechanism at their effective concentrations. The detailed study on the antibacterial mechanism of the most potent complex M7 revealed that it exerted its antibacterial activity by inhibiting the function of FtsZ and perturbing the localization of the Z-ring at the mid cell.