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Bergallo Massimiliano Canosa Stefano Galliano Ilaria Daprà Valentina Montanari Paola Sestero Marta Gennarelli Gianluca Benedetto Chiara Revelli Alberto Tovo Pier-Angelo 《Molecular biology reports》2021,48(7):5803-5808
Molecular Biology Reports - Human endogenous retroviruses (HERVs), remnants of ancestral infections, represent 8% of the human genome. HERVs are co-opted for important physiological functions... 相似文献
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Matteo Burigotto Alessia Mattivi Daniele Migliorati Giovanni Magnani Chiara Valentini Michela Roccuzzo Martin Offterdinger Massimo Pizzato Alexander Schmidt Andreas Villunger Stefano Maffini Luca L Fava 《The EMBO journal》2021,40(4)
Centrosome amplification results into genetic instability and predisposes cells to neoplastic transformation. Supernumerary centrosomes trigger p53 stabilization dependent on the PIDDosome (a multiprotein complex composed by PIDD1, RAIDD and Caspase‐2), whose activation results in cleavage of p53’s key inhibitor, MDM2. Here, we demonstrate that PIDD1 is recruited to mature centrosomes by the centriolar distal appendage protein ANKRD26. PIDDosome‐dependent Caspase‐2 activation requires not only PIDD1 centrosomal localization, but also its autoproteolysis. Following cytokinesis failure, supernumerary centrosomes form clusters, which appear to be necessary for PIDDosome activation. In addition, in the context of DNA damage, activation of the complex results from a p53‐dependent elevation of PIDD1 levels independently of centrosome amplification. We propose that PIDDosome activation can in both cases be promoted by an ANKRD26‐dependent local increase in PIDD1 concentration close to the centrosome. Collectively, these findings provide a paradigm for how centrosomes can contribute to cell fate determination by igniting a signalling cascade. 相似文献
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Brooke Sadler Jackson Wilborn Lilian Antunes Timothy Kuensting Andrew T. Hale Stephen R. Gannon Kevin McCall Carlos Cruchaga Matthew Harms Norine Voisin Alexandre Reymond Gerarda Cappuccio Nicola Brunetti-Pierri Marco Tartaglia Marcello Niceta Chiara Leoni Giuseppe Zampino Allison Ashley-Koch Gabe Haller 《American journal of human genetics》2021,108(3):530-531
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Weber Igor Daniel Lopes Welinton Ribamar de Paula Letícia Chiara Baldassio Albernaz-Godinho Karina Cordeiro Czepak Cecilia 《BioControl》2021,66(5):625-637
BioControl - Lepidopterans are among the most important groups of pests for crops in central Brazil. Fortunately, there is a significant diversity of natural enemies acting in the natural... 相似文献
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Bruno Golosio Chiara De Luca Cristiano Capone Elena Pastorelli Giovanni Stegel Gianmarco Tiddia Giulia De Bonis Pier Stanislao Paolucci 《PLoS computational biology》2021,17(6)
The brain exhibits capabilities of fast incremental learning from few noisy examples, as well as the ability to associate similar memories in autonomously-created categories and to combine contextual hints with sensory perceptions. Together with sleep, these mechanisms are thought to be key components of many high-level cognitive functions. Yet, little is known about the underlying processes and the specific roles of different brain states. In this work, we exploited the combination of context and perception in a thalamo-cortical model based on a soft winner-take-all circuit of excitatory and inhibitory spiking neurons. After calibrating this model to express awake and deep-sleep states with features comparable with biological measures, we demonstrate the model capability of fast incremental learning from few examples, its resilience when proposed with noisy perceptions and contextual signals, and an improvement in visual classification after sleep due to induced synaptic homeostasis and association of similar memories. 相似文献