全文获取类型
收费全文 | 1483篇 |
免费 | 96篇 |
出版年
2022年 | 10篇 |
2021年 | 47篇 |
2020年 | 28篇 |
2019年 | 31篇 |
2018年 | 34篇 |
2017年 | 31篇 |
2016年 | 55篇 |
2015年 | 56篇 |
2014年 | 66篇 |
2013年 | 92篇 |
2012年 | 135篇 |
2011年 | 117篇 |
2010年 | 57篇 |
2009年 | 54篇 |
2008年 | 70篇 |
2007年 | 57篇 |
2006年 | 64篇 |
2005年 | 47篇 |
2004年 | 41篇 |
2003年 | 41篇 |
2002年 | 34篇 |
2001年 | 31篇 |
2000年 | 14篇 |
1999年 | 19篇 |
1998年 | 12篇 |
1996年 | 9篇 |
1995年 | 8篇 |
1994年 | 16篇 |
1993年 | 9篇 |
1992年 | 34篇 |
1991年 | 22篇 |
1990年 | 19篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 15篇 |
1986年 | 10篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1981年 | 9篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1971年 | 11篇 |
1969年 | 8篇 |
1964年 | 9篇 |
1963年 | 5篇 |
排序方式: 共有1579条查询结果,搜索用时 15 毫秒
21.
The uptake of nutrients was investigated in the renal cortical brush border membrane (BBM) vesicles at different stages of ascending pyelonephritis. There was significant difference (p less than 0.05) in the uptake of D-glucose, L-alanine, L-aspartate, L-lysine and L-proline 3 days postinfection and onwards in both right unobstructed and left obstructed experimental kidneys as compared to the sham operated control. The uptake of D-glucose, L-lysine and L-proline was found to be significantly decreased (p less than 0.05) during the course of infection. While uptake of L-alanine and L-aspartate increased (p less than 0.05) in early stages and decreased (p less than 0.05) in later stages of infection. The differential effect was attributed to the compensatory measure and different kinds of transport systems for different types of amino acids. 相似文献
22.
23.
P Ganguly 《The Journal of biological chemistry》1971,246(13):4286-4290
24.
Sampath Parthasarathy Papasani V. Subbaiah Jagannath Ganguly 《The Biochemical journal》1974,140(3):503-508
1. The mechanism of absorption of phosphatidylcholine was studied in rats by injecting into the intestine phosphatidylcholine specifically labelled either in the fatty acid or in the glycerol moiety or with (32)P, when considerable amounts of 1-acyl-lysophosphatidylcholine were found in the intestinal lumen. 2-([(14)C]Acyl)phosphatidylcholine gave markedly more radioactive unesterified fatty acids in the lumen, compared with the 1-([(14)C]acyl) derivative. Some of the radioactivity from either the fatty acid or the glycerol moiety of the injected phosphatidylcholine appeared in the mucosal triacylglycerols. 2. Injection of (32)P-labelled phosphatidylcholine or (32)P-labelled lysophosphatidylcholine led to the appearance of radioactive glycerylphosphorylcholine, glycerophosphate and P(i) in the mucosa. 3. Rat mucosa was found to contain a highly active glycerylphosphorylcholine diesterase. 4. It was concluded that the dietary phosphatidylcholine is hydrolysed in the intestinal lumen by the pancreatic phospholipase A to 1-acylglycerylphosphorylcholine, which on entering the mucosal cell is partly reacylated to phosphatidylcholine, and the rest is further hydrolysed to glycerylphosphorylcholine, glycerophosphate, glycerol and P(i). The fatty acids and glycerophosphate are then reassembled to give triacylglycerols via the Kennedy (1961) pathway. 相似文献
25.
Studies on platelet proteins. IX. The identity of fibrinogen 总被引:1,自引:0,他引:1
26.
Studies on metabolism of vitamin A. The effect of hormones on gestation in retinoate-fed female rats 总被引:7,自引:6,他引:1
1. The preparation of cell suspensions by treatment of chick embryo hearts with collagenase at various stages of development is described. 2. Measurements of oxygen consumption, incorporation of labelled leucine into protein and accumulation of labelled alpha-aminoisobutyric acid against a concentration gradient indicated a long-lasting viability of the isolated heart cells in vitro; a satisfactory preservation of subcellular structures, including plasma membrane, was assessed by electron-microscopic examination. 3. The rate of alpha-aminoisobutyric acid accumulation by cardiac cells isolated from hearts at different stages of embryological development decreased with aging; insulin stimulated the intracellular accumulation of this amino acid analogue. 4. Insulin increased the uptake by isolated heart cells of several (14)C-labelled naturally occurring amino acids; however, the fraction of amino acid taken up by the cells that was recovered free intracellularly, and therefore the concentration ratio (between intracellular water and medium), was enhanced by the hormone only with glycine, proline, serine, threonine, histidine and methionine. When isolated heart cells were incubated in the presence of a mixture of labelled amino acids, the addition of insulin increased the disappearance of radioactivity from the medium. 5. The general pattern of amino acid transport (in the absence and in the presence of insulin) in isolated cardiac cells was similar to that found in intact hearts, suggesting that the biological preparation described in this paper might be useful for studies of cell permeability and insulin action. 相似文献
27.
28.
29.
C E Gomez-Sanchez P G Zager M F Foecking O B Holland A Ganguly 《Journal of steroid biochemistry》1989,32(3):409-412
The urinary excretion of 18-oxocortisol in 37 normal subjects consuming a normal sodium diet was 1.2 +/- 0.9(SD) microgram/24 h. Dexamethasone administration to 5 normal individuals suppressed the excretion of 18-oxocortisol from 1.16 +/- 0.5 micrograms/24 h to 0.6 +/- 0.2 micrograms/24 h. While they still received dexamethasone, ACTH administration raised the 18-oxo-cortisol excretion to 3.82 +/- 1.2 micrograms/24 h. Seven normal subjects were placed on a sodium restricted diet, and the urinary excretion of 18-oxocortisol rose from 1.5 +/- 1.21 micrograms/24 h to 8.54 +/- 5.08 micrograms/24 h and aldosterone from 6.6 +/- 2.0 micrograms/24 h to 39.7 +/- 14.6 micrograms/24 h. Two of the seven individuals showed minimal increases in the excretion of 18-oxocortisol, but in all cases aldosterone increased with sodium restriction. The urinary excretion of 18-oxocortisol correlated significantly with the excretion of aldosterone, 18-hydroxycortisol, cortisol, and 19-nordeoxycorticosterone. These studies indicate that 18-oxocortisol secretion is under ACTH regulation, but since sodium restriction also increases the excretion of 18-oxocortisol, the renin-angiotensin system must also participate in its regulation. However, some individuals do not increase their excretion of 18-oxocortisol with sodium restriction, although aldosterone excretion increases as expected, suggesting that additional factors participate in the regulation of 18-oxocortisol production. 相似文献
30.
S. Gulati M. Khullar B. K. Sharma N. K. Ganguly 《Molecular and cellular biochemistry》1996,156(1):37-42
Intracellular free Ca2+ concentration has been shown to be elevated in platelets of patients with essential hypertension. This study was designed to characterize Ca2+-pump activity of the platelet membranes (surface and intracellular) in these patients. A double-blind study was carried out. Untreated and treated (on R-blockers) essential hypertensives were studied in comparison with normotensive control subjects. First degree blood relatives of essential hypertensives were also studied. The Ca2+-activation kinetics of the enzyme showed a significant decrease in the Vmax. (for the plasma- and intracellular membranes) and Km (for the intracellular membranes) in the essential hypertensive patients. Increased platelet membrane cholesterol content was observed in these patients. Lowered Ca2+-efflux by Ca2+-ATPase may lead to elevated intracellular free Ca2+-levels in platelets of essential hypertensives. A lowered Ca2+-ATPase activity may emerge as a marker for essential hypertension. 相似文献