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101.
102.
Using a pericentromeric interspersed repeat to recapitulate the phylogeny and expansion of human centromeric segmental duplications 总被引:3,自引:0,他引:3
Horvath JE Gulden CL Bailey JA Yohn C McPherson JD Prescott A Roe BA de Jong PJ Ventura M Misceo D Archidiacono N Zhao S Schwartz S Rocchi M Eichler EE 《Molecular biology and evolution》2003,20(9):1463-1479
Despite considerable advances in sequencing of the human genome over the past few years, the organization and evolution of human pericentromeric regions have been difficult to resolve. This is due, in part, to the presence of large, complex blocks of duplicated genomic sequence at the boundary between centromeric satellite and unique euchromatic DNA. Here, we report the identification and characterization of an approximately 49-kb repeat sequence that exists in more than 40 copies within the human genome. This repeat is specific to highly duplicated pericentromeric regions with multiple copies distributed in an interspersed fashion among a subset of human chromosomes. Using this interspersed repeat (termed PIR4) as a marker of pericentromeric DNA, we recovered and sequence-tagged 3 Mb of pericentromeric DNA from a variety of human chromosomes as well as nonhuman primate genomes. A global evolutionary reconstruction of the dispersal of PIR4 sequence and analysis of flanking sequence supports a model in which pericentromeric duplications initiated before the separation of the great ape species (>12 MYA). Further, analyses of this duplication and associated flanking duplications narrow the major burst of pericentromeric duplication activity to a time just before the divergence of the African great ape and human species (5 to 7 MYA). These recent duplication exchange events substantially restructured the pericentromeric regions of hominoid chromosomes and created an architecture where large blocks of sequence are shared among nonhomologous chromosomes. This report provides the first global view of the series of historical events that have reshaped human pericentromeric regions over recent evolutionary time. 相似文献
103.
Rocchi A Micheli D Ceravolo R Manca ML Tognoni G Siciliano G Murri L 《Genetic testing》2003,7(4):309-314
Patients with Alzheimer disease (AD) often exhibit psychotic symptoms associated with cognitive impairment. A few association studies have been carried out to determine if the serotonin transporter and receptor genes are potential risk factors for AD and/or associated psychopathology. The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy. No significant differences in the distribution of allele and genotype frequencies of 5-HTTLPR and 5-HT2A T102C were found between patient and control groups. However, a significant association between the C102/C102 5-HT2A genotype and psychotic symptoms (p < 0.001) was observed. Our data strongly confirm results from previous studies suggesting that the C102 allele of the 5-HT2A receptor is associated with the occurrence of psychotic symptoms in AD. On the contrary, the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of the disease. 相似文献
104.
105.
Picard F Géhin M Annicotte J Rocchi S Champy MF O'Malley BW Chambon P Auwerx J 《Cell》2002,111(7):931-941
We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expenditure. In white adipose tissue, lack of TIF2 decreases PPARgamma activity and reduces fat accumulation, whereas in brown adipose tissue it facilitates the interaction between SRC-1 and PGC-1alpha, which induces PGC-1alpha's thermogenic activity. Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism. 相似文献
106.
S Rocchi F Picard J Vamecq L Gelman N Potier D Zeyer L Dubuquoy P Bac M F Champy K D Plunket L M Leesnitzer S G Blanchard P Desreumaux D Moras J P Renaud J Auwerx 《Molecular cell》2001,8(4):737-747
FMOC-L-Leucine (F-L-Leu) is a chemically distinct PPARgamma ligand. Two molecules of F-L-Leu bind to the ligand binding domain of a single PPARgamma molecule, making its mode of receptor interaction distinct from that of other nuclear receptor ligands. F-L-Leu induces a particular allosteric configuration of PPARgamma, resulting in differential cofactor recruitment and translating in distinct pharmacological properties. F-L-Leu activates PPARgamma with a lower potency, but a similar maximal efficacy, than rosiglitazone. The particular PPARgamma configuration induced by F-L-Leu leads to a modified pattern of target gene activation. F-L-Leu improves insulin sensitivity in normal, diet-induced glucose-intolerant, and in diabetic db/db mice, yet it has a lower adipogenic activity. These biological effects suggest that F-L-Leu is a selective PPARgamma modulator that activates some (insulin sensitization), but not all (adipogenesis), PPARgamma-signaling pathways. 相似文献
107.
A Baldini M Rocchi N Archidiacono O J Miller D A Miller 《American journal of human genetics》1990,46(4):784-788
We have isolated a DNA clone (pBR12, locus D12Z3) which identifies an alphoid subset specific for chromosome 12. This alphoid subset has an EcoRI periodicity of 680 bp and is characterized by a higher-order repeat of about 1.4 kb (eight basic units of about 170 bp each) as revealed by several restriction enzymes. The sequence analysis confirmed the alphoid nature of pBR12 and the dimeric organization. 相似文献
108.
A silver stain (Kt) technique was used to analyze the centromeric area in metacentric chromosomes originating from Robertsonian rearrangements in the mouse. The 2n=40 all-acrocentric mouse karyotype and two Robertsonian-rearranged karyotypes (2n=24 and 2n=26 from Upper Valtellina) were used. The existence was demonstrated of a single centromeric pattern common to metacentric and to acrocentric chromosomes except for the Y, and consisting of two deeply stained dots, one per chromatid. In many cells this technique stains the nucleolar organizers and resolves the paracentromeric constitutive heterochromatin in chromomeres. 相似文献
109.
A tool for the preliminary identification of unknown and unforeseeable periods in biological rhythms is presented. This method, called 'maximization of mean vector length', is based on circular statistics assumptions. It can be used effectively as an exploratory tool in the analysis of chronobiological data, while it carries a high risk of type I statistical error when used as a confirmative method. However, a correction term is provided in order to reduce this risk. An example of the application of this method to a set of spontaneous delivery data is also included. 相似文献
110.