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Literature shows that Flaviviruses cause a variety of diseases, including fevers, encephalitis, and hemorrhagic fevers. NS3 is a multifunctional protein with an Nterminal protease domain (NS3pro) that is responsible for proteolytic processing of the viral polyprotein, and a C-terminal region that contains an RNA triphosphatase, RNA helicase and RNA-stimulated NTPase domain that are essential for RNA replication. Therefore, NS3 protein is the preferential choice for inhibition to stop the proteolytic processing. Hence, the 3D structure of NS3 protein was modeled using homology modeling by MODELLER 9v7. Evaluation of the constructed NS3 protein models were done by PROCHECK, VERYFY3D and through ProSA calculations. Ligands for the catalytic triad were designed using LIGBUILDER. The NS3 protein's catalytic triad was explored to find out the critical interactions pattern for inhibitor binding using molecular docking methodology using AUTODOCK Vina. It should be noted that these predicted data should be validated using suitable assays for further consideration. ABBREVIATIONS: DOPE - Discrete optimized protein energy, WHO - World Health Organization, ADME/T - Absorption, Distribution, Metabolism, Excretion and Toxicity. 相似文献
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Summary Growth response to griseofulvin has been studied in 24 strains of 16 species of geophilic dermatophytes and related keratinophilic fungi. Based on their sensitivity to griseofulvin these fungi fall into three groups: (1) Resistant group includesKeratinomyces ajelloi, Trichophyton terrestre andTrichophyton evolceanui which can grow upto 40µg per ml concentration of griseofulvin. (2) Fairly resistant group comprisingMicrosporon cookei, Microsporon vanbreuseghemii, a strain ofMicrosporon gypseum andTrichophyton sp., with growth occurring upto 8–16µg per ml concentration. (3) Sensitive group includes species ofTrichophyton, Keratinophyton, Microsporon, Nannizzia, Chrysosporium andCtenomyces which are completely inhibited at 4–8µg or lower griseofulvin concentrations. Griseofulvin inhibited formation of cleistothecia inK. terreum, delayed pleomorphic growth inT. indicum andN. incurvata, and influenced pigment production in several strains. 相似文献
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Rupendeep?Kaur Sukhleen?Bindra?NarangEmail author Deep?Kamal?Kaur?Randhawa 《Journal of molecular modeling》2018,24(3):63
Electrical charge transport through thiophene-dithiol-based molecular wires attached to gold electrodes with three different types of crystallographic orientations (<1,1,1>, <1,1,0 >?and <1,0,1?>) was investigated. Electron transport in the systems under consideration was evaluated systematically by analyzing current values, transmission spectrum, projected device density of states and zero bias orbital analysis utilizing density functional theory in conjunction with non-equilibrium Green’s function. Investigations proved that tuning of conductance in nano-molecular junctions is possible through different electrode orientations. As the HOMO–LUMO gap in the <1,1,0?>?oriented thiophene dithiol junction is drastically less than that of the other configurations under consideration, the <1,1,0?> configuration exhibited superior constructive conductance in comparison to other junction orientations. This provided us with ideas for designing pioneering hetero-cyclic nano-scale electronics devices. Also, <1,1,0?>?has been found to show negative differential conductance behavior above +2.6 V and below ?2.6 V, and hence has potential applications in oscillating and switching circuits. 相似文献
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Normal vibration analysis of cyclic tetraglycine has been carried out employing the Urey-Bradley force field and the vibrational assignments are compared with those in related molecules. 相似文献