全文获取类型
收费全文 | 806篇 |
免费 | 39篇 |
出版年
2023年 | 4篇 |
2022年 | 16篇 |
2021年 | 44篇 |
2020年 | 26篇 |
2019年 | 7篇 |
2018年 | 20篇 |
2017年 | 10篇 |
2016年 | 14篇 |
2015年 | 24篇 |
2014年 | 30篇 |
2013年 | 53篇 |
2012年 | 57篇 |
2011年 | 51篇 |
2010年 | 31篇 |
2009年 | 23篇 |
2008年 | 44篇 |
2007年 | 41篇 |
2006年 | 33篇 |
2005年 | 27篇 |
2004年 | 25篇 |
2003年 | 24篇 |
2002年 | 13篇 |
2001年 | 19篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 4篇 |
1997年 | 16篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1976年 | 3篇 |
1972年 | 6篇 |
1965年 | 3篇 |
1963年 | 3篇 |
排序方式: 共有845条查询结果,搜索用时 15 毫秒
831.
Chandan Prasad A. Jayaraman Hugh J. F. Robertson Jayashree K. Rao 《Neurochemical research》1987,12(9):767-774
Cyclo(His-Pro), or histidyl-proline diketopiperazine, is an endogenous cyclic dipeptide that is ubiquitously distributed in tissues and body fluids of both man and animals. This cyclic dipeptide is not only structurally related to thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), but it can also arise from TRH by the action of the enzyme pyroglutamate amino-peptidase (pGlu-peptidase). The data on the distribution of TRH, cyclo(His-Pro), and pGlu-peptidase under normal and abnormal conditions are summarized and potential relationships analyzed. We conclude that all of the cyclo(His-Pro) cannot be derived from TRH. Two additional sources of cyclo(His-Pro) are suggested. It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)]. 相似文献
832.
833.
Ramya Rangan Andrew M Watkins Jose Chacon Rachael Kretsch Wipapat Kladwang Ivan N Zheludev Jill Townley Mats Rynge Gregory Thain Rhiju Das 《Nucleic acids research》2021,49(6):3092
The rapid spread of COVID-19 is motivating development of antivirals targeting conserved SARS-CoV-2 molecular machinery. The SARS-CoV-2 genome includes conserved RNA elements that offer potential small-molecule drug targets, but most of their 3D structures have not been experimentally characterized. Here, we provide a compilation of chemical mapping data from our and other labs, secondary structure models, and 3D model ensembles based on Rosetta''s FARFAR2 algorithm for SARS-CoV-2 RNA regions including the individual stems SL1-8 in the extended 5′ UTR; the reverse complement of the 5′ UTR SL1-4; the frameshift stimulating element (FSE); and the extended pseudoknot, hypervariable region, and s2m of the 3′ UTR. For eleven of these elements (the stems in SL1–8, reverse complement of SL1–4, FSE, s2m and 3′ UTR pseudoknot), modeling convergence supports the accuracy of predicted low energy states; subsequent cryo-EM characterization of the FSE confirms modeling accuracy. To aid efforts to discover small molecule RNA binders guided by computational models, we provide a second set of similarly prepared models for RNA riboswitches that bind small molecules. Both datasets (‘FARFAR2-SARS-CoV-2’, https://github.com/DasLab/FARFAR2-SARS-CoV-2; and ‘FARFAR2-Apo-Riboswitch’, at https://github.com/DasLab/FARFAR2-Apo-Riboswitch’) include up to 400 models for each RNA element, which may facilitate drug discovery approaches targeting dynamic ensembles of RNA molecules. 相似文献
834.
835.
836.
837.
838.
Sankari Mohan Hridya Hemachandran P. Sneha C. George Priya Doss J. Godwin Christopher Gurunathan Jayaraman 《Journal of biomolecular structure & dynamics》2018,36(8):2085-2098
Bixin and crocin are natural apocarotenoids utilized as food colorants and additives in food industries worldwide. For safety assessment, it is necessary to understand the biological interaction of food colorants. In our present study, we report the interaction of two apocarotenoids with bovine serum albumin (BSA) at physiological pH using spectroscopic techniques and in silico tools. The binding constant and the mode of binding sites have been studied. The enthalpic and entropic contribution to the intermolecular binding event was analyzed and it was found that the contribution of hydrogen bonding and hydrophobic interactions was dominant. The adverse temperature dependence in the unusual static quenching is found to be a reasonable consequence of the large activation energy requirement in the binding process, which is required to overcome the fundamental block and is a direct result of the unique microstructure of the binding sites. To confirm the experimental analysis, we investigated the binding patterns using different in silico tools. A combination of molecular docking, molecular dynamics, and toxicity analysis was performed, and the obtained results revealed that both the apocarotenoids had high binding affinity with a binding energy of ?5.44 and ?5.93 kcal/mol for bixin and crocin, respectively, with no toxic effects and are in accordance with our experimental analysis. The results directly revealed the flexibility of the protein toward bixin and crocin which has a great impact on the interaction. Thus bixin and crocin can guardedly be used as food colorants in food industries. 相似文献
839.
840.