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91.
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias 总被引:31,自引:14,他引:31
Genes sequences from Escherichia coli, Salmonella typhimurium, and other
members of the Enterobacteriaceae show a negative correlation between the
degree of synonymous-codon usage bias and the rate of nucleotide
substitution at synonymous sites. In particular, very highly expressed
genes have very biased codon usage and accumulate synonymous substitutions
very slowly. In contrast, there is little correlation between the degree of
codon bias and the rate of protein evolution. It is concluded that both the
rate of synonymous substitution and the degree of codon usage bias largely
reflect the intensity of selection at the translational level. Because of
the high variability among genes in rates of synonymous substitution,
separate molecular clocks of synonymous substitution might be required for
different genes.
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Alexia de Matos Czeczot Candida Deves Roth Rodrigo Gay Ducati Kenia Pissinate Raoní Scheibler Rambo Luís Fernando Saraiva Macedo Timmers Bruno Lopes Abbadi Fernanda Souza Macchi Víctor Zajaczkowski Pestana Luiz Augusto Basso Pablo Machado Cristiano Valim Bizarro 《Journal of enzyme inhibition and medicinal chemistry》2021,36(1):847
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycobacterium tuberculosis (MtFolB) is essential for bacilli survival and represents an important molecular target for drug development. S8-functionalized 8-mercaptoguanine derivatives were synthesised and evaluated for inhibitory activity against MtFolB. The compounds showed IC50 values in the submicromolar range. The inhibition mode and inhibition constants were determined for compounds that exhibited the strongest inhibition. Additionally, molecular docking analyses were performed to suggest enzyme-inhibitor interactions and ligand conformations. To the best of our knowledge, this study describes the first class of MtFolB inhibitors. 相似文献
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Retention of cryptic genes in microbial populations 总被引:5,自引:0,他引:5
Cryptic genes are silenced genes that can still be reactivated by mutation.
Since they can make no positive contribution to the fitness of their
carriers, it is not clear why many cryptic genes in microbial populations
have not degenerated into useless DNA sequences. Hall et al. (1983) have
suggested that cryptic genes have persisted because of occasional strong
environmental selection for reactivated genes. The present mathematical
study supports their suggestion. It shows that a cryptic gene can be
retained without having any selective advantage over a useless DNA
sequence, if selection for the reactivated gene occasionally occurs for a
substantially long time.
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