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31.
Asthma is one of the most common chronic inflammatory disorder of the airways of the lungs, affecting more than 300 million people all over the world. Nitric oxide (NO) is endogenously produced in mammalian airways by nitric oxide synthase (NOS) and is known to regulate many aspects of human asthma, including the modulation of airway and vascular smooth muscle tone and the inflammation. Asthmatic patients show an increased expression of inducible nitric oxide synthase (iNOS) in airway epithelial cells and an increased level of NO in exhaled air. Using various NO inhibitors (non-specific or iNOS-specific) and gene knock-out experiments, controversial results have been obtained regarding iNOS's beneficial and deleterious effects in the disease. In the present review, we have attempted to summarize the results of these experiments and also the genetic studies being undertaken to understand the role of iNOS in asthma. It is argued that extensive biochemical, clinical and genetic studies will be required to assess the precise role of NO in the asthma. This may help in designing selective and more potent iNOS inhibitors and NO donors for developing novel therapeutics for the asthma patients. 相似文献
32.
Liu X Alli R Steeves M Nguyen P Vogel P Geiger TL 《Journal of immunology (Baltimore, Md. : 1950)》2012,189(2):669-678
IL-10 is a critical anti-inflammatory cytokine, the deficiency of which leads to spontaneous autoimmunity. However, therapeutically administered or ectopically expressed IL-10 can either suppress or promote disease. Distinct lineage-specific activities may explain the contradictory effects of IL-10. To dissect the T cell-specific response to IL-10 during organ-specific autoimmunity, we generated mice with a selective deletion of IL-10Rα in T cells and analyzed its effects in an autoimmune model, experimental allergic encephalomyelitis (EAE). Surprisingly, the T cell response to IL-10 increased EAE severity. This did not result from altered T cell functional potential; T cell cytokine profile was preserved. IL-10 also diminished the proliferation of T cells in situ within the target organ, an effect that would be expected to restrain disease. However, IL-10 acted cell autonomously to sustain the autoreactive T cells essential for immunopathogenesis, promoting their accumulation and distorting the regulatory and effector T cell balance. Indeed, in chimeric mice and after adoptive transfer, wild type T cells showed a competitive advantage over cells deficient in IL-10Rα. Therefore, T cell specific actions of IL-10 can support autoimmune inflammation, and this appears to result from an overall increase in the long term fitness of pathologic T cells. Lineage-restricted, disease-promoting activities of IL-10 should be considered in the therapeutic manipulation of the IL-10 pathway. 相似文献
33.
M.B. Hart C. Rajshekhar M. Fitzpatrick J.A. Milton A.J. Wadsworth 《Historical Biology》2013,25(2-4):309-319
In the United Kingdom the base of the Aptian transgression is located at the base of the Perna Beds (on the Isle of Wight), although recent work on the magnetostratigraphy has indicated that this dating may be in error. Micropalaeontological work on the Isle of Wight sections has shown that the Perna Beds represent a complex event at the transition from a non‐marine to a marine succession. Foraminiferal and palynological data agree on this transition, although no biostratigraphically diagnostic taxa are present. The base of the Aptian is tentatively moved downwards to the level of the Barnes, High Sandstone Member (Vectis Formation). If correct, this realignment of the boundary would necessitate a revision of many stratigraphic ranges and diversity calculations. 相似文献