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排序方式: 共有397条查询结果,搜索用时 15 毫秒
21.
Gupta Bharti Kumar Anoop Sridevi Parikipandla 《International journal of peptide research and therapeutics》2021,27(4):2717-2726
International Journal of Peptide Research and Therapeutics - Human papillomavirus (HPV) remains the major cause of cervical cancer, globally. High risk HPV (Hr-HPV) 16 and 18 together account for... 相似文献
22.
Decrease in soil water potential during vegetative and flowering stages of two cultivars of pipeon pea (Cajanus cajari) caused higher decrease in relative water content in cv. ICPL-151 than in cv. H-77-216. Both cultivars showed partial recovery during rehydration. Cv. H-77-216 also accumulated more proline and carbohydrates during stress and showed better drought tolerance than cv. ICPL-151. 相似文献
23.
Anjana Sharma Sachin Kumar Chandraker Manisha Bharti 《Indian journal of microbiology》2007,47(3):233-240
Sixteen isolates of Nontubercular Mycobacteria species were isolated from drinking water supply of some educational institutes
in Jabalpur during July 2006 and were identified by biochemical test, thin layer chromatography (TLC) and high performance
liquid chromatography (HPLC) analysis and PRA ( PCR restriction enzyme analysis) of rpoB gene. Out of 21 water samples total
16 isolates of nontuberculous mycobacteria were identified, as M. terrae (6), M. szulgai (4), M. gordonae (3), and one each as M. malmoense, M. kansasii, and M. gastri. 相似文献
24.
25.
Jason J. Rudd Kostya Kanyuka Keywan Hassani-Pak Mark Derbyshire Ambrose Andongabo Jean Devonshire Artem Lysenko Mansoor Saqi Nalini M. Desai Stephen J. Powers Juliet Hooper Linda Ambroso Arvind Bharti Andrew Farmer Kim E. Hammond-Kosack Robert A. Dietrich Mikael Courbot 《Plant physiology》2015,167(3):1158-1185
26.
27.
Swati Agarwal Shashi Kant Tiwari Brashket Seth Anuradha Yadav Anshuman Singh Anubha Mudawal Lalit Kumar Singh Chauhan Shailendra Kumar Gupta Vinay Choubey Anurag Tripathi Amit Kumar Ratan Singh Ray Shubha Shukla Devendra Parmar Rajnish Kumar Chaturvedi 《The Journal of biological chemistry》2015,290(34):21163-21184
The human health hazards related to persisting use of bisphenol-A (BPA) are well documented. BPA-induced neurotoxicity occurs with the generation of oxidative stress, neurodegeneration, and cognitive dysfunctions. However, the cellular and molecular mechanism(s) of the effects of BPA on autophagy and association with oxidative stress and apoptosis are still elusive. We observed that BPA exposure during the early postnatal period enhanced the expression and the levels of autophagy genes/proteins. BPA treatment in the presence of bafilomycin A1 increased the levels of LC3-II and SQSTM1 and also potentiated GFP-LC3 puncta index in GFP-LC3-transfected hippocampal neural stem cell-derived neurons. BPA-induced generation of reactive oxygen species and apoptosis were mitigated by a pharmacological activator of autophagy (rapamycin). Pharmacological (wortmannin and bafilomycin A1) and genetic (beclin siRNA) inhibition of autophagy aggravated BPA neurotoxicity. Activation of autophagy against BPA resulted in intracellular energy sensor AMP kinase (AMPK) activation, increased phosphorylation of raptor and acetyl-CoA carboxylase, and decreased phosphorylation of ULK1 (Ser-757), and silencing of AMPK exacerbated BPA neurotoxicity. Conversely, BPA exposure down-regulated the mammalian target of rapamycin (mTOR) pathway by phosphorylation of raptor as a transient cell''s compensatory mechanism to preserve cellular energy pool. Moreover, silencing of mTOR enhanced autophagy, which further alleviated BPA-induced reactive oxygen species generation and apoptosis. BPA-mediated neurotoxicity also resulted in mitochondrial loss, bioenergetic deficits, and increased PARKIN mitochondrial translocation, suggesting enhanced mitophagy. These results suggest implication of autophagy against BPA-mediated neurodegeneration through involvement of AMPK and mTOR pathways. Hence, autophagy, which arbitrates cell survival and demise during stress conditions, requires further assessment to be established as a biomarker of xenoestrogen exposure. 相似文献
28.
Four species of the ant genus Ponera Latreille, 1804, are recorded from India. The present study reports one new species Ponera
sikkimensis
sp. n., a divergent population of Ponera
indica Bharti & Wachkoo, 2012 and one new record, Ponera
paedericera Zhou, 2001 from India. An identification key and distributions for the four known Indian species of Ponera based on the worker caste are provided. 相似文献
29.
A soluble β-galactoside binding 14.5 kDa lectin was purified from the heart of Capra hircus. Its metal independent nature, preferential affinity for β-d-lactose and 90–94% homology with carbohydrate recognition domain of previously reported galectin-1 confirmed its inclusion
in galectin-1 subfamily. The secondary structures of the deduced amino acid sequences were generally conserved with previously
reported Gal-1. Exposure of the purified protein to varying temperature and pH, oxidant, thiol blocking reagents, denaturants
and detergents resulted in significant changes in UV (ultraviolet), fluorescence, CD (circular dichroism) and FTIR (fourier
transform infra red) spectra, thus strongly emphasizing the vitality of regular secondary structure of galectins for maintaining
their active conformation. Bioinformatics studies corroborated the results obtained in wet lab. Our findings based on physico-chemical
properties, oxidative inactivation and structural analysis of the goat heart galectin-1 suggests significant implications
in potential biological and clinical applications. 相似文献
30.
Drought acclimation reduces O2*- accumulation and lipid peroxidation in wheat seedlings 总被引:1,自引:0,他引:1
Selote DS Bharti S Khanna-Chopra R 《Biochemical and biophysical research communications》2004,314(3):724-729
Abiotic stresses cause ROS accumulation, which is detrimental to plant growth. It is well known that acclimation of plants under mild or sub-lethal stress condition leads to development of resistance in plants to severe or lethal stress condition. The generation of ROS and subsequent oxidative damage during drought stress is well documented in the crop plants. However, the effect of drought acclimation treatment on ROS accumulation and lipid peroxidation has not been examined so far. In this study, the effect of water stress acclimation treatment on superoxide radical (O(2)(-z.rad;)) accumulation and membrane lipid peroxidation was studied in leaves and roots of wheat (Triticum aestivum) cv. C306. EPR quantification of superoxide radicals revealed that drought acclimation treatment led to 2-fold increase in superoxide radical accumulation in leaf and roots with no apparent membrane damage. However under subsequent severe water stress condition, the leaf and roots of non-acclimated plants accumulated significantly higher amount of superoxide radicals and showed higher membrane damage than that of acclimated plants. Thus, acclimation-induced restriction of superoxide radical accumulation is one of the cellular processes that confers enhanced water stress tolerance to the acclimated wheat seedlings. 相似文献