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191.
Vishal K. Patel Lissa Padnick-Silver Sherwin D’Souza Rajib K. Bhattacharya Megan Francis-Sedlak Robert J. Holt 《Endocrine practice》2022,28(2):159-164
ObjectiveThyroid eye disease (TED) is a debilitating autoimmune disease characterized by ocular and periorbital tissue inflammation, proptosis, and visual impairment. The known risk factors for TED include radioactive iodine therapy, female sex, and smoking. The risk factors for severe TED include hyperthyroidism, male sex, smoking, and diabetes; however, little is known about how diabetes mellitus (DM) influences TED. This claims-based analysis examined TED characteristics in patients with and without diabetes.MethodsSymphony database (2010-2015 U.S. claims) was mined for patients with ≥1 Graves’ disease diagnosis code and ≥1 TED-associated eye code, including proptosis, strabismus, diplopia, lid retraction, exposure keratoconjunctivitis, and optic neuropathy (ON). DM status was determined based on type 1 or type 2 diabetes coding. Sight-threatening TED was defined as ≥1 ON or exposure keratoconjunctivitis code.ResultsA total of 51 220 patients were identified. Of them, 2618 (5.1%) and 12 846 (25.1%) had type 1 and type 2 DM, respectively. Patients with and without DM had similar characteristics, but patients with DM were more often men (type 1: 30.3%, type 2: 28.7% vs no DM: 20.5%; both P < .001) and older at the first TED code. In patients with DM, strabismus (25.4%, 22.6% vs 19.9%) and diplopia (38.6%, 37.9% vs 29.9%) occurred more often but proptosis occurred less often (42.3%, 46.3% vs 58.5%; all P < .001). Sight-threatening TED occurred more often in patients with DM because of higher ON rates.ConclusionPatients with TED and DM may have more extraocular muscle involvement. Furthermore, the higher prevalence of severe TED stemmed from higher ON rates, possibly associated with diabetes-related vasculopathies. These hypothesis-generating data warrant further exploration. 相似文献
192.
The influence of estrogen, progesterone and testosterone on the activities of alkaline and acid phosphatases, adenosine triphosphatase and succinate dehydrogenase were determined by cytochemical methods in sarcoma 180 and Ehrlich's carcinoma cells transplanted in male and female Swiss mice. The results revealed differential effects of the sex hormones on different enzymes which seemed to depend on the type of tumour cell studied and the sex of the host mice. 相似文献
193.
Dhrubajyoti Gogoi Rajib Lochan Bezbaruah Manabjyoti Bordoloi Rajeev Sarmah Tarun Chandra Bora 《Bioinformation》2012,8(17):812-815
Litsea spp of Laural family are traditionally used as herbal medicine for treating inflammation including gastroenterologia, oedema
and rheumatic arthritis. Therefore, it is of interest to investigate and understand the molecular principles for such actions. Here, we
have illustrated the binding of thirteen Litsea derived biologically active compounds against the inflammation associated target
COX (cyclo-oxygenase) -2 enzymes. We compared the binding information of these compounds with a selected number of already
known COX-2 inhibitors. The comparison reflected that some of these compounds such as linderol, catechin, 6''-hydroxy-2'',3'',4'' -
trimethoxy-chalcone and litseaone have better or equivalent binding features compared to already known inhibitory compounds
namely celecoxib, acetylsalicylic acid, rofecoxib. Therefore, all these small compounds reported from plant Litsea spp were found to
possess potential medicinal values with anti-inflammatory properties. 相似文献
194.
Yi Zhou Sergey Alexandrov Andrew Nolan Nandan Das Rajib Dey Martin Leahy 《Journal of biophotonics》2020,13(6)
Corneal cross‐linking (CXL) using ultraviolet‐A (UVA) irradiation with a riboflavin photosensitizer has grown from an interesting concept to a practical clinical treatment for corneal ectatic diseases globally, such as keratoconus. To characterize the corneal structural changes, existing methods such as X‐ray microscopy, transmission electron microscopy, histology and optical coherence tomography (OCT) have been used. However, these methods have various drawbacks such as invasive detection, the impossibility for in vivo measurement, or limited resolution and sensitivity to structural alterations. Here, we report the application of oversampling nanosensitive OCT for probing the corneal structural alterations. The results indicate that the spatial period increases slightly after 30 minutes riboflavin instillation but decreases significantly after 30 minutes UVA irradiation following the Dresden protocol. The proposed noninvasive method can be implemented using existing OCT systems, without any additional components, for detecting nanoscale changes with the potential to assist diagnostic assessment during CXL treatment, and possibly to be a real‐time monitoring tool in clinics. 相似文献
195.
Plasmonics - This work describes an ultrasensitive trace determination of cadmium ion in aqueous medium through hybrid nanocomposite. Biodegradable materials such as chitosan and PVA are used to... 相似文献