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841.
Elizabeth V. Minten Priya Kapoor-Vazirani Chunyang Li Hui Zhang Kamakshi Balakrishnan David S. Yu 《Cell reports》2021,34(13):108921
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842.
Priya Anand 《Molecular simulation》2013,39(6):440-448
Amyloid deposits are a hallmark of many diseases. In the case of Alzheimer's disease, a turn between 21Ala and 30Ala, stabilised by a salt bridge between 22Glu/23Asp and 28Lys, may nucleate folding and aggregation of the amyloid β (Aβ) peptide. In the present paper, we test this hypothesis by studying how salt bridge and turn formation vary with intrinsic and environmental changes, and how these changes affect folding and aggregation of the Aβ-peptide. 相似文献
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844.
Keshaav Krishnaa Pothapur Veeraraghavan Vishnu Priya Gayathri Rengasamy Vijayashree Priyadharsini Jayaseelan 《Bioinformation》2020,16(11):837
Periodontitis is attributed to the dental biofilm formation. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5 - (4 - hydroxy styryl) benzene 1,3 diol). We report a list of potential proteins having optimal drug like binding features with the herbal agent Resveratrol for further consideration. We used the STITCH v.5 pipeline VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound resveratrol were thus identified and reported for further consideration. 相似文献
845.
Jyothi K. Rajashekar Jonathan Richard Jagadish Beloor Jérémie Prévost Sai Priya Anand Guillaume Beaudoin-Bussières Liang Shan Dietmar Herndler-Brandstetter Gabrielle Gendron-Lepage Halima Medjahed Catherine Bourassa Fleur Gaudette Irfan Ullah Kelly Symmes Andrew Peric Emily Lindemuth Frederic Bibollet-Ruche Jun Park Priti Kumar 《Cell host & microbe》2021,29(6):904-916.e6
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846.
847.
Faisal Bin Rahman Sium Ahmed Priya Noor Mir Md. Mahbubur Rahman S.M. Azimul Huq Md. Taharat Elahi Akib Abdullah Mohammad Shohael 《Biochemistry and Biophysics Reports》2020
Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. are three ornamental plants that produce colorful flowers. The present study aimed to evaluate the phytochemicals and bioactivities of methanolic extracts of flowers from Delonix regia (DrFME), Cassia fistula (CfFME), and Lagerstroemia speciosa (LsFME). The presence of ten different chemical classes in varying degrees was confirmed while qualitatively screened. During quantitative determination, LsFME possesses the highest amount of total phenolic (418.0 mg/g), flavonoid (50.8 mg/g), and tannin (256.3 mg/g) contents. The extracts showed excellent antioxidant capacity in a concentration-dependent manner with the lowest IC50 value (41.51 μg/mL) displayed by LsFME. LsFME paralyzed the experimental worms at 2.95 min and killed at 3.96 min. DrFME was found to be more effective in thrombolytic (35.5% clot lysis) and anticoagulant activities. Negligible hemolytic activity (IC50 > 200 μg/mL) found for all extracts which suggest their less potential toxicity. The in vivo experiments revealed that the CfFME has the highest analgesic (64.34% pain inhibition) activity while LsFME has the highest antidiarrheal (70.27% inhibition) and antihyperglycemic (46.94% inhibition) activities at 400 mg/kg of body weight doses. This study has shown the presence of phytochemicals and potential bioactivities which indicates the possibility of these flowers to be used as a source of phytochemicals as well as safe and effective natural medicine. 相似文献
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Alexandra Tauzin Manon Nayrac Mehdi Benlarbi Shang Yu Gong Romain Gasser Guillaume Beaudoin-Bussières Nathalie Brassard Annemarie Laumaea Dani Vézina Jérémie Prévost Sai Priya Anand Catherine Bourassa Gabrielle Gendron-Lepage Halima Medjahed Guillaume Goyette Julia Niessl Olivier Tastet Laurie Gokool Andrés Finzi 《Cell host & microbe》2021,29(7):1137-1150.e6
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