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171.
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here, we combined laboratory natural selection (experimental evolution) in Drosophila melanogaster with genome‐wide next generation sequencing of DNA pools (Pool‐Seq) to identify alleles that are favourable in a novel laboratory environment and traced their trajectories during the adaptive process. Already after 15 generations, we identified a pronounced genomic response to selection, with almost 5000 single nucleotide polymorphisms (SNP; genome‐wide false discovery rates < 0.005%) deviating from neutral expectation. Importantly, the evolutionary trajectories of the selected alleles were heterogeneous, with the alleles falling into two distinct classes: (i) alleles that continuously rise in frequency; and (ii) alleles that at first increase rapidly but whose frequencies then reach a plateau. Our data thus suggest that the genomic response to selection can involve a large number of selected SNPs that show unexpectedly complex evolutionary trajectories, possibly due to nonadditive effects. 相似文献
172.
Impact of adrenal versus ovarian androgen ratio on signs and symptoms of polycystic ovarian syndrome
Köşüş N Köşüş A Kamalak Z Hızlı D Turhan NÖ 《Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology》2012,28(8):611-614
The aim of this study was to examine the effect of adrenal versus ovarian androgen (dehydroepiandrosterone sulfate/total testosterone [DHEAS/TT]) on clinical presentation and related metabolic disturbances in Turkish women with polycystic ovarian syndrome (PCOS). Two hundred eighty PCOS cases were taken into the study. For all cases, the DHEAS/TT ratio was calculated. The median value of this ratio was 4.40. Patients with an androgen ratio lower than 4.40 were included in Group 1 and cases with a ratio higher than 4.40 were Group 2. The two groups were compared in terms of hormonal, biochemical and clinical parameters. Body mass index and waist circumference were lower, the Ferriman-Gallwey score was higher and the cycle length was shorter in Group 2. High DHEAS level was associated with better lipid profiles and lower levels of inflammatory markers, meaning good metabolic control in these women, in spite of increased hirsutism rates. In patients with PCOS, both androgens are usually high in proportion to each other. Therefore, it would be more meaningful to use the DHEAS/TT ratio for an assessment of the metabolic and phenotypic effects of PCOS. 相似文献
173.
Hui Geng Kutty Selva Nandakumar Anna Pramhed Anders Aspberg Ragnar Mattsson Rikard Holmdahl 《Arthritis research & therapy》2012,14(4):1-14
Introduction
Cartilage oligomeric matrix protein (COMP) is a major non-collagenous component of cartilage. Earlier, we developed a new mouse model for rheumatoid arthritis using COMP. This study was undertaken to investigate the epitope specificity and immunopathogenicity of COMP-specific monoclonal antibodies (mAbs).Methods
B cell immunodominant regions on the COMP molecule were measured with a novel enzyme-linked immunosorbent assay using mammalian expressed full-length mouse COMP as well as a panel of recombinant mouse COMP fragments. 18 mAbs specific to COMP were generated and the pathogenicity of mAbs was investigated by passive transfer experiments.Results
B cell immunodominant epitopes were localized within 4 antigenic domains of the COMP but with preferential response to the epidermal growth factor (EGF)-like domain. Some of our anti-COMP mAbs showed interactions with the native form of COMP, which is present in cartilage and synovium. Passive transfer of COMP-specific mAbs enhanced arthritis when co-administrated with a sub-arthritogenic dose of a mAb specific to collagen type II. Interestingly, we found that a combination of 5 COMP mAbs was capable of inducing arthritis in naive mice.Conclusions
We have identified the specificities of mAbs to COMP and their contribution to the development of arthritis. These findings will further improve our understanding of the autoantibody mediated immunopathologies occurring widely in rheumatoid arthritis (RA), as well as in other autoimmune disorders. 相似文献174.
Barış Özener 《Evolution and human behavior》2012,33(3):169-173
Recently, Weston et al. (2004; Wide faces or large canines? The attractive versus the aggressive primate. Proceedings of the Royal Society of London, Series B, 271, 416–419) found that facial width-to-height ratio (WHR) is a sexually dimorphic characteristic in humans; males have higher facial WHR than females. Following this study, Carré et al. (2008; In your face: facial metrics predict aggressive behavior in the laboratory and in varsity and professional hockey players. Proceedings of the Royal Society of London, Series B, 275, 2651–2656) found that individual differences in facial WHR accounted for a significant proportion of the variance in aggressive behavior of men, but not women. I tested these two hypotheses in a sample of 470 Turkish university students. Facial WHR was measured from frontal photographs. I also measured the aggressiveness level of 212 individuals using the Buss and Perry aggressiveness questionnaire. The mean facial WHR (and standard deviation) was 1.89±0.12 for males and 1.91±0.11 for females. There was no relationship between facial WHR and the self-reported aggressive behavior for either sex. The facial WHR is not a sexually dimorphic characteristic (at least) for Turkish people, and it does not appear to be associated with self-reported trait aggression. 相似文献
175.
Emerging evidence identifies multiple roles for nucleoside-diphosphate-kinase in host-microbe interaction. We provide the first synopsis of utilization of this molecule by various microorganisms during colonization of host tissues. Additionally, we propose novel mechanisms this effector may participate in, which could be crucial for microbial adaptation in chronic host infection. 相似文献
176.
MZ Adzemovic J Öckinger M Zeitelhofer S Hochmeister AD Beyeen A Paulson A Gillett M Thessen Hedreul R Covacu H Lassmann T Olsson M Jagodic 《PloS one》2012,7(7):e39794
Multiple sclerosis (MS) is a polygenic disease characterized by inflammation and demyelination in the central nervous system (CNS), which can be modeled in experimental autoimmune encephalomyelitis (EAE). The Eae18b locus on rat chromosome 10 has previously been linked to regulation of beta-chemokine expression and severity of EAE. Moreover, the homologous chemokine cluster in humans showed evidence of association with susceptibility to MS. We here established a congenic rat strain with Eae18b locus containing a chemokine cluster (Ccl2, Ccl7, Ccl11, Ccl12 and Ccl1) from the EAE- resistant PVG rat strain on the susceptible DA background and utilized myelin oligodendrocyte glycoprotein (MOG)-induced EAE to characterize the mechanisms underlying the genetic regulation. Congenic rats developed a milder disease compared to the susceptible DA strain, and this was reflected in decreased demyelination and in reduced recruitment of inflammatory cells to the brain. The congenic strain also showed significantly increased Ccl11 mRNA expression in draining lymph nodes and spinal cord after EAE induction. In the lymph nodes, macrophages were the main producers of CCL11, whereas macrophages and lymphocytes expressed the main CCL11 receptor, namely CCR3. Accordingly, the congenic strain also showed significantly increased Ccr3 mRNA expression in lymph nodes. In the CNS, the main producers of CCL11 were neurons, whereas CCR3 was detected on neurons and CSF producing ependymal cells. This corresponded to increased levels of CCL11 protein in the cerebrospinal fluid of the congenic rats. Increased intrathecal production of CCL11 in congenic rats was accompanied by a tighter blood brain barrier, reflected by more occludin(+) blood vessels. In addition, the congenic strain showed a reduced antigen specific response and a predominant anti-inflammatory Th2 phenotype. These results indicate novel mechanisms in the genetic regulation of neuroinflammation. 相似文献
177.
TREVOR EDWARDS MARK HUGHES MICHAEL MÖLLER DIRK BELLSTEDT 《Botanical journal of the Linnean Society. Linnean Society of London》2008,158(4):743-748
Two new rosulate species of Streptocarpus are described from the eastern seaboard of South Africa. The first is endemic to Mpumalanga Province. This species has almost actinomorphic corollas with small cylindrical tubes and was previously included within Streptocarpus parviflorus. However, molecular and morphological data and habitat preference do not support this classification. The second species is from the Msikaba River Gorge in the Eastern Cape Province. It adds to the already impressive list of endemic plant species from this region and is allied to other rosulate species of the Eastern Cape. It approaches Streptocarpus rexii in flower size but differs in its much shorter corolla tubes, which lack purple nectar guides. In addition, the corolla floors are marked with yellow bars reminiscent of Streptocarpus cyaneus and also seen in sympatric populations of the small‐flowered Streptocarpus modestus. © 2008 The Linnean Society of London, Botanical Journal of the Linnean Society, 2008, 158 , 743–748. 相似文献
178.
Dissipation of excess absorbed light energy in eukaryotic photoautotrophs through zeaxanthin- and DeltapH-dependent photosystem II antenna quenching is considered the major mechanism for non-photochemical quenching and photoprotection. However, there is mounting evidence of a zeaxanthin-independent pathway for dissipation of excess light energy based within the PSII reaction centre that may also play a significant role in photoprotection. We summarize recent reports which indicate that this enigma can be explained, in part, by the fact that PSII reaction centres can be reversibly interconverted from photochemical energy transducers that convert light into ATP and NADPH to efficient, non-photochemical energy quenchers that protect the photosynthetic apparatus from photodamage. In our opinion, reaction centre quenching complements photoprotection through antenna quenching, and dynamic regulation of photosystem II reaction centre represents a general response to any environmental condition that predisposes the accumulation of reduced Q(A) in the photosystem II reaction centres of prokaryotic and eukaryotic photoautotrophs. Since the evolution of reaction centres preceded the evolution of light harvesting systems, reaction centre quenching may represent the oldest photoprotective mechanism. 相似文献
179.
180.
In this study, the anatomical features of the leaf and stem, besides the pollen and nutlet characteristics of Teucrium sandrasicum are investigated. T. sandrasicum, belonging to sect. Teucrium, is an endemic perennial herb growing on serpentine around Muğla province. The anatomical studies on T. sandrasicum revealed that the stem shares the general characteristics of the Labiatae family. The leaves clearly exhibit xeromorphy due
to features such as the distribution of stomata on the lower surface (hipostomatic), the occurrence of guard cells below the
epidermis (xeromorphic type), inrolled margins, thick cuticle layer, thick outer epidermal cell wall, a high density of trichomes
and thick palisade layer of the mesophyll. The anatomical studies showed that the upper epidermal cells of the leaf include
many spherocrystals. The pollen grains are prolate, medium in size, 3-colpate with verrucate ornamentation. The nutlets are
ellipsoid with a reticulate-verrucate surface. The results have proven that T. sandrasicum is different from the other species of the sect. Teucrium because of the branched trichomes on the stem and the lack of eglandular trichomes on the nutlets. 相似文献