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排序方式: 共有436条查询结果,搜索用时 234 毫秒
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Joseph J Hudak Erin Killeen Ashok Chandran J Craig Cohen Janet E Larson 《Respiratory research》2009,10(1):34
One of the mechanisms by which adult disease can arise from a fetal origin is by in utero disruption of organogenesis. These studies were designed to examine respiratory function changes in aging rats following transient disruption of lung growth at 16 days gestation. Fetuses were treated in utero with a replication deficient adenovirus containing the cystic fibrosis conductance transmembrane regulator (CFTR) gene fragment cloned in the anti-sense direction. The in utero-treated rats demonstrated abnormal lung function beginning as early as 30 days of age and the pathology progressed as the animals aged. The pulmonary function abnormalities included decreased static compliance as well as increased conducting airway resistance, tissue damping, and elastance. Pressure volume (PV) curves demonstrated a slower early rise to volume and air trapping at end-expiration. The alterations of pulmonary function correlated with lung structural changes determined by morphometric analysis. These studies demonstrate how transient disruption of lung organogensis by single gene interference can result in progressive change in lung function and structure. They illustrate how an adult onset disease can arise from subtle changes in gene expression during fetal development. 相似文献
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Jayprakash Narayan Kumar Parigi Raghavendar Reddy Biswanath Das C. Ganesh Kumar Pombala Sujitha 《Bioorganic & medicinal chemistry letters》2013,23(18):5192-5194
Stereoselective total synthesis of bioactive marine natural product crucigasterin A has been accomplished from commercially available and inexpensive l-(?)-malic acid as a starting material. Julia olefination and chelation controlled Grignard additions are the key steps involved in the present synthesis. Cytotoxic properties of crucigasterin A and its related analogues crucigasterins B and D have been evaluated. Crucigasterin A showed promising activities against both the human cervical cancer cell line and human breast adenocarcinoma cell line. 相似文献
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Biological influence of infant death on fertility 总被引:1,自引:0,他引:1
P E Chandran 《Journal of biosocial science》1989,21(2):217-221
This study examines the biological influence of infant death on subsequent fertility in three Asian countries--Indonesia, Nepal and Sri Lanka, comparing the birth interval between two consecutive births up to the sixth birth by survival status of the preceding infant among breast-feeding women not using contraception. There is consistent evidence of biological influence in each of the three countries. Infant death shortens birth intervals by up to 30%, though its influence varies between the countries. 相似文献