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Claire Lavigne Benoît Ricci Pierre Franck Rachid Senoussi 《Basic and Applied Ecology》2010,11(8):734-742
Analysing spatial patterns of population distributions may help to infer the decisive underlying ecological processes. Here we propose a method adapted to the spatial analysis of count data. Named MAPCOMP (MAP COMParison), it is based on the calculation of a formal distance, the Hellinger distance, between the density map of counts and the density map of sampling effort. Statistical tests of spatial homogeneity are based on count permutations across sampling sites and on valuable properties of the Hellinger distance. We assessed the efficiency of MAPCOMP by simulating different types and locations of clusters of individuals and compared its performance to the classical red–blue SADIE method, used as a reference. The two methods were also compared with respect to counts of codling moth larvae in orchards. Thanks to its better theoretical properties than SADIE, MAPCOMP was efficient in detecting spatial inhomogeneity when clusters were located on square or elongated spatial domains and more or less close to the edges, even for small sample sizes. It also appeared not very sensitive to edge effects. Another advantage of MAPCOMP is a bandwidth parameter that allows assessing the spatial extent of heterogeneity, if any. 相似文献
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Rachid Hanna Alexis Onzo Robert Lingeman J. Steve Yaninek Maurice W. Sabelis 《Population Ecology》2005,47(2):107-117
We applied time series analysis and a mechanistic predator-prey model to long-term data of monthly population counts of the herbivorous pest mite Mononychellus tanajoa and its introduced phytoseiid predator Typhlodromalus aripo from a cassava field in Benin, West Africa. In this approach, we determined the extent to which the main features of the observed predator-prey fluctuations in cassava fields can be explained from biotic traits inherent to the biology of predator and prey, and the extent of the significance of abiotic factors in determining population levels. The time series analyses with cross-correlation showed that the period of predator-prey fluctuations coincided with the annual pattern of intense rainfall and onset of dry season. A pronounced M. tanajoa peak followed after a short lag (2 weeks) by a T. aripo peak coincided with a trough in rainfall intensity. Both the prey and predator had local and lower peaks that coincided with high rainfall intensity, but with a considerably longer lag (ca. 3 months) compared with the high peaks occurring at the onset of the dry season. Regression of log-transformed data series (over a 7-year period) showed that—except for the first year after predator release—M. tanajoa fluctuated around an almost time-invariant mean population density, while T. aripo densities showed a consistent decline over the full observation period. To explain observed trends and periodic components in the data-series of predator and prey densities, we review hypotheses that are based on (1) the annual patterns and trends in abiotic factors, (2) mechanisms endogenous to the predator-prey system and (3) a combination of exogenous and endogenous factors. 相似文献
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Ousmane Sao Pierre Giresse Henry de Lumley avec la participation de Cécile Chapon Christian Perrenoud Mouamar Ould Rachid 《L'Anthropologie》2008,112(1):1
In the Mauritanian Adrar, the Guelb er-Richât and, in particular, the depression of its external ring are the location of rather exceptional Acheulian industry accumulations discovered by Théodore Monod. These sites may have originated from one or more non dated humid phases where seasonal water presence induced faunal and thus predator presence. Piedmont relief, foot slope rock flow and deltaic spreads attest, until the last humid Holocene, the permanence of particularly favourable sectors like upstream of Akerdil and Bamouéré wadis. Outcrops or chaos of Chinguetti quartzite sandstone have supplied the necessary raw material for tool confection; the second factor favouring the presence of these Acheulian sites. The rather difficult aim of the authors is first, to locate lithics in stratigraphic position and second, to establish a chronostratigraphy. Some first examples are presented. 相似文献
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Rachid MA Camargos ER Barcellos L Marques CA Chiari E Huang H Tanowitz HB Teixeira MM Machado CR 《Microbes and infection / Institut Pasteur》2006,8(8):2113-2119
Endothelin has been implicated in the pathogenesis of experimental and human Chagas' disease (American trypanosomiasis). In the present study, we tested the effect of bosentan, an antagonist of both ET(A) and ET(B) endothelin receptors, on parasitemia, histopathology (heart and diaphragm), heart levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, interferon (IFN)-gamma, CCL2, CCL3 and CCL5, and the serum levels of nitrate/nitrite (NOx). Bosentan treatment was accompanied by a significant increase in parasitemia and tissue parasitism or inflammation. In vehicle-treated rats, Trypanosoma cruzi infection increased the cardiac levels of TNF-alpha, IFN-gamma and IL-10, at day 9 post inoculation, and the TNF-alpha remained elevated until day 13. The infection also caused a significant increase in the cardiac levels of the chemokines CCL2 (9, 13 and 18 days) and CCL3 (13 and 18 days). Bosentan-treatment had no significant effect on the infection-associated increase in IFN-gamma and chemokine concentrations. There was a lower increase in IL-10 at day 9 and this was mirrored by a greater increase of TNF-alpha at day 13, in comparison with vehicle-treated rats. These latter findings correlated well with the enhanced inflammatory process in hearts of bosentan-treated infected rats. Bosentan treatment reduced the infection-associated increase in NOx serum concentration. Altogether, our data suggest that ET action on ET(A) and ET(B) receptors may play a role in the initial control of T. cruzi infection in rats probably by interfering in NO production. 相似文献
388.
Seidah NG Mayer G Zaid A Rousselet E Nassoury N Poirier S Essalmani R Prat A 《The international journal of biochemistry & cell biology》2008,40(6-7):1111-1125
The mammalian secretory proprotein convertases are part of a family of nine serine proteinases of the subtilisin-type. Seven of them cleave after basic amino acids and are called PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7. The two other convertases SKI-1/S1P and PCSK9 are implicated in cholesterol and/or fatty acid metabolism. The convertases PC5/6 and PACE4 are activated at the cell surface where they are tethered to heparan sulfate proteoglycans. This activation pathway is unique and differs from that of furin and PC7, which are activated in the trans-Golgi network and from PC1/3 and PC2 that are activated in dense core secretory granules. While some of the basic amino acid-specific convertases may display redundant cleavages of substrates, they uniquely process certain substrates in vivo. Indeed, the conditional knockout of the PC5/6 gene in the embryo proper in mice led to severe malformations, bone morphogenic defects and death at birth. This is likely due to the absence of processing of the growth differentiating factor 11 (Gdf11). Both complete and liver-specific knockout of Pcsk9 revealed that it is a major convertase that regulates the level of circulating low-density lipoproteins (LDL) via the degradation of the hepatic LDL-receptor. This apparently non-enzymatic mechanism implicates the enhanced degradation of the LDLR in endosomes/lysosomes. These data provide evidence that an inhibitor of PCSK9-LDLR interaction is a viable target for the development of a novel cholesterol lowering drug in conjunction with the classical statins. 相似文献
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