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The Irano-Turanian distribution zone in the Levant crossroad is fragmented along different phyto- and zoogeographic and climatic regions, a relict of wider distribution in moister conditions during the Pleistocene and the Holocene. We examined the effect of the disjunct Irano-Turanian distribution among distinct mesic and xeric habitats on the genetic structure of the gall-forming aphid Slavum wertheimae and its obligate host tree Pistacia atlantica in Israel and Jordan. The genetic study included amplified fragment length polymorphism analysis of the trees and aphids and sequence analysis of fragments of the mitochondrial genes cytochrome oxidase I and II (COI and COII) of the aphids. P. atlantica trees did not show any differentiation or genetic structure among climatic regions. S. wertheimae aphids in Israel exhibited two distinct phylogenetic groups, one occupying the mesic region in the north and the other inhabiting the xeric south. The Jordanian aphids clustered within the Israeli northern populations. The results suggest that while the fragmented Irano-Turanian distribution in the Levant does not affect the genetic structure of P. atlantica trees, it promotes genetic differentiation among the aphids?? populations and may initiate an allopatric speciation. 相似文献
875.
Rogers AD Tyler PA Connelly DP Copley JT James R Larter RD Linse K Mills RA Garabato AN Pancost RD Pearce DA Polunin NV German CR Shank T Boersch-Supan PH Alker BJ Aquilina A Bennett SA Clarke A Dinley RJ Graham AG Green DR Hawkes JA Hepburn L Hilario A Huvenne VA Marsh L Ramirez-Llodra E Reid WD Roterman CN Sweeting CJ Thatje S Zwirglmaier K 《PLoS biology》2012,10(1):e1001234
Since the first discovery of deep-sea hydrothermal vents along the Galápagos Rift in 1977, numerous vent sites and endemic faunal assemblages have been found along mid-ocean ridges and back-arc basins at low to mid latitudes. These discoveries have suggested the existence of separate biogeographic provinces in the Atlantic and the North West Pacific, the existence of a province including the South West Pacific and Indian Ocean, and a separation of the North East Pacific, North East Pacific Rise, and South East Pacific Rise. The Southern Ocean is known to be a region of high deep-sea species diversity and centre of origin for the global deep-sea fauna. It has also been proposed as a gateway connecting hydrothermal vents in different oceans but is little explored because of extreme conditions. Since 2009 we have explored two segments of the East Scotia Ridge (ESR) in the Southern Ocean using a remotely operated vehicle. In each segment we located deep-sea hydrothermal vents hosting high-temperature black smokers up to 382.8°C and diffuse venting. The chemosynthetic ecosystems hosted by these vents are dominated by a new yeti crab (Kiwa n. sp.), stalked barnacles, limpets, peltospiroid gastropods, anemones, and a predatory sea star. Taxa abundant in vent ecosystems in other oceans, including polychaete worms (Siboglinidae), bathymodiolid mussels, and alvinocaridid shrimps, are absent from the ESR vents. These groups, except the Siboglinidae, possess planktotrophic larvae, rare in Antarctic marine invertebrates, suggesting that the environmental conditions of the Southern Ocean may act as a dispersal filter for vent taxa. Evidence from the distinctive fauna, the unique community structure, and multivariate analyses suggest that the Antarctic vent ecosystems represent a new vent biogeographic province. However, multivariate analyses of species present at the ESR and at other deep-sea hydrothermal vents globally indicate that vent biogeography is more complex than previously recognised. 相似文献
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Raben N Wong A Ralston E Myerowitz R 《American journal of medical genetics. Part C, Seminars in medical genetics》2012,160(1):13-21
Macroautophagy (often referred to as autophagy) is an evolutionarily conserved intracellular system by which macromolecules and organelles are delivered to lysosomes for degradation and recycling. Autophagy is robustly induced in response to starvation in order to generate nutrients and energy through the lysosomal degradation of cytoplasmic components. Constitutive, basal autophagy serves as a quality control mechanism for the elimination of aggregated proteins and worn-out or damaged organelles, such as mitochondria. Research during the last decade has made it clear that malfunctioning or failure of this system is associated with a wide range of human pathologies and age-related diseases. Our recent data provide strong evidence for the role of autophagy in the pathogenesis of Pompe disease, a lysosomal glycogen storage disease caused by deficiency of acid alpha-glucosidase (GAA). Large pools of autophagic debris in skeletal muscle cells can be seen in both our GAA knockout model and patients with Pompe disease. In this review, we will focus on these recent data, and comment on the not so recent observations pointing to the involvement of autophagy in skeletal muscle damage in Pompe disease. 相似文献
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Glenn A. Marsh Carol de Jong Jennifer A. Barr Mary Tachedjian Craig Smith Deborah Middleton Meng Yu Shawn Todd Adam J. Foord Volker Haring Jean Payne Rachel Robinson Ivano Broz Gary Crameri Hume E. Field Lin-Fa Wang 《PLoS pathogens》2012,8(8)
The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known about the associated mechanisms of pathogenesis. Here, we report the isolation and characterization of a new paramyxovirus from pteropid bats, Cedar virus (CedPV), which shares significant features with the known henipaviruses. The genome size (18,162 nt) and organization of CedPV is very similar to that of HeV and NiV; its nucleocapsid protein displays antigenic cross-reactivity with henipaviruses; and it uses the same receptor molecule (ephrin- B2) for entry during infection. Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication and production of neutralizing antibodies although clinical disease was not observed. In this context, it is interesting to note that the major genetic difference between CedPV and HeV or NiV lies within the coding strategy of the P gene, which is known to play an important role in evading the host innate immune system. Unlike HeV, NiV, and almost all known paramyxoviruses, the CedPV P gene lacks both RNA editing and also the coding capacity for the highly conserved V protein. Preliminary study indicated that CedPV infection of human cells induces a more robust IFN-β response than HeV. 相似文献
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