The biosynthesis of cytochrome P450 by heavy and light rough endoplasmic reticulum of rat liver

The synthesis of cytochrome P450 by heavy rough endoplasmic reticulum and light rough endoplasmic reticulum has been examined in vitro, using immunochemical techniques. Contrary to previous indications the results show no evidence for preferential segregation of the cytochrome P450 m-RNA and that the presence of mitochondrial protein synthesis accounts for the differences that have previously been reported.     

Single dose responses to the gonadotropin-releasing hormone agonist analogue [(imBz 1)-D-His6,Pro9-NEt]GnRH

The agonist analogue of gonadotropin-releasing hormone (GnRH), [(imBz1)-D-His6,Pro9-NEt]GnRH, has a potency 200 times that of the native hormone in vitro. In single dose studies in man, this analogue resulted in 2- to 4-fold elevation of LH and FSH, and demonstrated a prolonged duration of activity. [(imBz1)-D-His6,Pro9-NEt]GnRH appears to be safe and, as with other analogues of GnRH, may have application to clinical medicine.     

Chemical biology: Paper alert

A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in chemical biology.