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71.
BRETT K. SANDERCOCK WILLIAM E. JENSEN CHRISTOPHER K. WILLIAMS ROGER D. APPLEGATE 《The Journal of wildlife management》2008,72(4):970-982
Abstract: The northern bobwhite (Colinus virginianus) is an economically important gamebird that is currently undergoing widespread population declines. Despite considerable research on the population ecology of bobwhites, there have been few attempts to model population dynamics of bobwhites to determine the contributions of different demographic parameters to variance of the finite rate of population change (Λ). We conducted a literature review and compiled 405 estimates of 9 demographic parameters from 49 field studies of bobwhites. To identify demographic parameters that might be important for management, we used life-stage simulation analyses (LSA) to examine sensitivity of Λ to simulated variation in 9 demographic parameters for female bobwhites. In a baseline LSA based on uniform distributions bounded by the range of estimates for each demographic parameter, bobwhite populations were predicted to decline (Λ = 0.56) and winter survival of adults made the greatest contribution to variance of Λ (r2 = 0.453), followed by summer survival of adults (r2 = 0.163), and survival of chicks (r2 = 0.120). Population change was not sensitive to total clutch laid, nest survival, egg hatchability, or 3 parameters associated with the number of nesting attempts (r2<0.06). Our conclusions were robust to alternative simulation scenarios, and parameter rankings changed only if we adjusted the lower bounds of winter survival upwards. Bobwhite populations were not viable with survival rates reported from most field studies. Survival rates may be depressed below sustainable levels by environmental conditions or possibly by impacts of capture and telemetry methods. Overall, our simulation results indicate that management practices that improve seasonal survival rates will have the greatest potential benefit for recovery of declining populations of bobwhites. 相似文献
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DONG‐SEOK KIM SOOK‐YOUNG KIM SEONG‐JOON MOON JIN‐HO CHUNG KYU‐HAN KIM KWANG‐HYUN CHO KYOUNG‐CHAN PARK 《Pigment cell & melanoma research》2001,14(2):110-115
Ceramide is a bioactive sphingolipid that mediates a variety of cell functions. However, the effects of ceramide on cell growth and the melanogenesis of melanocytes are not known. In the present study, we investigated the actions of cell‐permeable ceramide and its possible role in the signaling pathway of a spontaneously immortalized mouse melanocyte cell line, Mel‐Ab. Our results show that C2‐ceramide inhibits DNA synthesis in Mel‐Ab cells and G361 human melanoma cells in a dose‐dependent manner. Cell cycle analysis confirmed the inhibition of DNA synthesis by a reduction in the S phase. To investigate the ceramide signaling pathway, we studied whether C2‐ceramide is able to influence extracellular signal‐regulated kinase (ERK) and/or Akt/protein kinase B (PKB) activation. We demonstrated that phosphorylated Akt/PKB is decreased by C2‐ceramide, whereas phosphorylated ERK was only slightly affected. Therefore, the C2‐ceramide‐induced inactivation of Akt/PKB may be closely related to the reduced cell proliferation of Mel‐Ab cells. Furthermore, we assessed the effects of C2‐ceramide on the pigmentation of Mel‐Ab cells. The results obtained showed that the melanin content of cells was significantly reduced by C2‐ceramide at concentrations in the range of 1–10 μM, and that the pigmentation‐inhibiting effect of C2‐ceramide is much greater than that of kojic acid at 1–100 μM. In addition, we found that the activity of tyrosinase is reduced by C2‐ceramide treatment. Our results demonstrate that C2‐ceramide reduces the pigmentation of Mel‐Ab cells by inhibiting tyrosinase activity. 相似文献
74.
The Miocene palaeobathymetry and palaeoenvironments of Carriacou, the Grenadines, Lesser Antilles 总被引:1,自引:0,他引:1
STEPHEN DONOVAN RON PICKERILL ROGER PORTELL TREVOR JACKSON DAVID HARPER 《Lethaia: An International Journal of Palaeontology and Stratigraphy》2003,36(3):255-272
Carriacou, a small island in the Grenadines, Lesser Antilles, has a Cenozoic rock record that has been important in interpreting the geologic history of the Southern Lesser Antilles Arc Platform. The Lower‐Middle Miocene sedimentary succession of the southeast and east coasts, consisting of the Belmont, Kendeace, Carriacou and Grand Bay formations, has been interpreted as a shallowing‐upward sequence from turbidite basin to nearshore?/beach? palaeoenvironments. An earlier interpretation of the Belmont Formation as having been deposited in shallow water is at variance with the turbiditic nature of the succession; the included fossils are considered allochthonous. However, an interpretation of the Grand Bay Formation as deep water is supported by multiple lines of evidence, including sedimentology (turbidites), ichnology (autochthonous association of burrows typical of deep‐water environments) and palaeontology (terrestrial, planktic, and shallow and deep water benthic species mixed together). The minimum depth of deposition of the Grand Bay Formation was 150–200 m. This suggests that the (unseen) contact between the Carriacou and Grand Bay formations is either an unconformity, formed following rapid deepening of the basin, or a fault, the Grand Bay Formation being deposited in a separate basin from the shallowing‐upwards Belmont‐Kendeace‐Carriacou formations, against which it is now juxtaposed 相似文献
75.
This study evaluated the results of fine needle aspiration cytology (FNAC) from the first four years of organized mammography screening for breast cancer in Oslo, particularly our policy in differentiating in situ and invasive carcinoma. Lesions were aspirated directly, ultrasound guided, by stereotaxic device or biopsy localization plate. All lesions were aspirated by cytopathologists working with the radiologists at the breast diagnostic centre. Smears were evaluated immediately for assessment of adequacy and a preliminary diagnosis was given to the surgeon. When FNAC revealed malignancy, diagnostic terms were as follows: (1) invasive carcinoma; (2) ductal carcinoma in situ of comedo type (high nuclear grade), cannot evaluate infiltration; (3) ductal carcinoma in situ of low nuclear grade and (4) papillary tumour, cannot evaluate infiltration. There were 953 cases, 70% of which were nonpalpable. Insufficient material was obtained in 5.8%. Absolute and complete sensitivity were 81% and 91%, respectively. Specificity was 85%. There were 448 histologically proven carcinomas. 383 of these were invasive. 362 carcinomas (in situ and invasive) (80.8%) were diagnosed directly on FNAC. Distinction between invasive and in situ carcinoma was possible in 294 of 320 directly diagnosed invasive carcinomas (91.8%). PPV of a diagnosis of invasive carcinoma was 97%. Our data showed that definitive cytological diagnosis of invasive carcinoma was possible in more than 90% of fully diagnostic smears and allowed definitive primary surgery in these women. 相似文献
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78.
Copper tolerance in the green alga, Chlorella vulgaris 总被引:1,自引:0,他引:1
Abstract. The effect of sub-lethal concentrations of copper upon tolerant and non-tolerant strains of Chlorella vulgaris was investigated. Copper concentrations of 0.2 and 0.4 mg dm−3 increased the lag phase of both strains, the effect being greater in the non-tolerant strain. No difference was observed in the toxicity of copper to the photosynthetic rates of the isolated chloroplasts of either strain. However, significant differences were shown at the whole cell level.
Lower copper uptake was shown by the tolerant cells. In both strains initial uptake of copper was followed by a phase of desorption before cell division occurred. In cultures of both strains the concentration of ionic copper was decreased by complexation with extracellular organic material. Over a 14 day growth period more organic material was produced by the tolerant cells. The organic material produced by the tolerant cell formed organo-copper complexes which had a higher conditional stability constant.
It is proposed that the cell wall acts as a barrier to copper in the tolerant cells and prevents copper from affecting cell metabolism. Organo-copper complexation occurs at this barrier and this complex is then released into the medium. 相似文献
Lower copper uptake was shown by the tolerant cells. In both strains initial uptake of copper was followed by a phase of desorption before cell division occurred. In cultures of both strains the concentration of ionic copper was decreased by complexation with extracellular organic material. Over a 14 day growth period more organic material was produced by the tolerant cells. The organic material produced by the tolerant cell formed organo-copper complexes which had a higher conditional stability constant.
It is proposed that the cell wall acts as a barrier to copper in the tolerant cells and prevents copper from affecting cell metabolism. Organo-copper complexation occurs at this barrier and this complex is then released into the medium. 相似文献
79.
Seasonal variation in septal spacing of Sepia officinalis and some Ordovician actinocerid nautiloids
ROGER A. HEWITT BRYAN STAIT 《Lethaia: An International Journal of Palaeontology and Stratigraphy》1988,21(4):383-394
Studies of cuttlebone of Sepia officinalis L. from the English Channel show a direct and linear correlation between ambient water temperature and septal spacing. The application of this observation to fossil shallow-water nautiloids and ammonoids is complicated by the equatorial habitat of many of these shells, their declining rate of chamber production through ontogeny and a paucity of large and complete specimens. But annual temperature variations are the most likely cause of variations in septal spacing a priori , temperature apparently being the prime determinant of feeding and growth rates of individuals at a particular ontogenetic stage. ▭ Nautiloids, annual growth, Ordovician , Sepia, English Channel. 相似文献
80.