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381.
Plant species diversity as a driver of early succession in abandoned fields: a multi-site approach 总被引:15,自引:0,他引:15
W. H. Van der Putten S. R. Mortimer K. Hedlund C. Van Dijk V. K. Brown J. Lepä C. Rodriguez-Barrueco J. Roy T. A. Diaz Len D. Gormsen G. W. Korthals S. Lavorel I. Santa Regina P. Smilauer 《Oecologia》2000,124(1):91-99
Succession is one of the most studied processes in ecology and succession theory provides strong predictability. However,
few attempts have been made to influence the course of succession thereby testing the hypothesis that passing through one
stage is essential before entering the next one. At each stage of succession ecosystem processes may be affected by the diversity
of species present, but there is little empirical evidence showing that plant species diversity may affect succession. On
ex-arable land, a major constraint of vegetation succession is the dominance of perennial early-successional (arable weed)
species. Our aim was to change the initial vegetation succession by the direct sowing of later-successional plant species.
The hypothesis was tested that a diverse plant species mixture would be more successful in weed suppression than species-poor
mixtures. In order to provide a robust test including a wide range of environmental conditions and plant species, experiments
were carried out at five sites across Europe. At each site, an identical experiment was set up, albeit that the plant species
composition of the sown mixtures differed from site to site. Results of the 2-year study showed that diverse plant species
mixtures were more effective at reducing the number of natural colonisers (mainly weeds from the seed bank) than the average
low-diversity treatment. However, the effect of the low-diversity treatment depended on the composition of the species mixture.
Thus, the effect of enhanced species diversity strongly depended on the species composition of the low-diversity treatments
used for comparison. The effects of high-diversity plant species mixtures on weed suppression differed between sites. Low-productivity
sites gave the weakest response to the diversity treatments. These differences among sites did not change the general pattern.
The present results have implications for understanding biological invasions. It has been hypothesised that alien species
are more likely to invade species-poor communities than communities with high diversity. However, our results show that the
identity of the local species matters. This may explain, at least partly, controversial results of studies on the relation
between local diversity and the probability of being invaded by aliens.
Received: 13 July 1999 / Accepted: 4 February 2000 相似文献
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385.
P. E. Mortimer J. S. Stewart A. P. Norman C. C. Booth 《BMJ (Clinical research ed.)》1968,3(5609):7-1,9
In 9 out of 10 adults in whom a diagnosis of coeliac disease had been made in childhood, the diagnosis was confirmed by the finding of a flat intestinal mucosa. None showed abnormal physical signs, but three had a haemoglobin concentration below 10 g./100 ml. and all those not receiving folic acid supplements showed low serum folate levels. Five had moderate to severe symptoms at the time of investigation, but none was receiving treatment with a gluten-free diet.Periodic investigation of these patients may be necessary throughout life, and if they are found to have malnutrition they should be treated with a gluten-free diet. 相似文献
386.
Yongzhong Hou Leanne Mortimer Kris Chadee 《The Journal of biological chemistry》2010,285(46):35497-35504
Integrins are important mammalian receptors involved in normal cellular functions and the pathogenesis of inflammation and disease. Entamoeba histolytica is a protozoan parasite that colonizes the gut, and in 10% of infected individuals, causes amebic colitis and liver abscess resulting in 105 deaths/year. E. histolytica-induced host inflammatory responses are critical in the pathogenesis of the disease, yet the host and parasite factors involved in disease are poorly defined. Here we show that pro-mature cysteine proteinase 5 (PCP5), a major virulent factor that is abundantly secreted and/or present on the surface of ameba, binds via its RGD motif to αVβ3 integrin on Caco-2 colonic cells and stimulates NFκB-mediated pro-inflammatory responses. PCP5 RGD binding to αVβ3 integrin triggered integrin-linked kinase(ILK)-mediated phosphorylation of Akt-473 that bound and induced the ubiquitination of NF-κB essential modulator (NEMO). As NEMO is required for activation of the IKKα-IKKβ complex and NFκB signaling, these events markedly up-regulated pro-inflammatory mediator expressions in vitro in Caco-2 cells and in vivo in colonic loop studies in wild-type and Muc2−/− mice lacking an intact protective mucus barrier. These results have revealed that EhPCP5 RGD motif is a ligand for αVβ3 integrin-mediated adhesion on colonic cells and represents a novel mechanism that E. histolytica trophozoites use to trigger an inflammatory response in the pathogenesis of intestinal amebiasis. 相似文献
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Hormone replacement therapy associated risks, and the concomitant reluctance of usage, has instigated the search for new generations of estrogen analogues that would maintain estrogen benefits without associated risks. Furthermore, if these analogues display chemo-preventative properties in breast and endometrial tissues it would be of great value. Both the selective estrogen receptor modulators as well as the selective estrogen receptor subtype modulators have been proposed as estrogen analogues with improved risk profiles. Phytoestrogen containing extracts of Cyclopia, an indigenous South African fynbos plant used to prepare Honeybush tea may serve as a source of new estrogen analogues. In this study three extracts, P104, SM6Met, and cup-of-tea, from two species of Cyclopia, C. genistoides and C. subternata, were evaluated for ER subtype specific agonism and antagonism both in transactivation and transrepression. For transactivation, the Cyclopia extracts displayed ERα antagonism and ERβ agonism when ER subtypes were expressed separately, however, when co-expressed only agonism was uniformly observed. In contrast, for transrepression, this uniform behavior was lost, with some extracts (P104) displaying uniform agonism, while others (SM6Met) displayed antagonism when subtypes were expressed separately and agonism when co-expressed. In addition, breast cancer cell proliferation assays indicate that extracts antagonize cell proliferation in the presence of estrogen at lower concentrations than that required for proliferation. Furthermore, lack of uterine growth and delayed vaginal opening in an immature rat uterotrophic model validates the ERα antagonism of extracts observed in vitro and supports the potential of the Cyclopia extracts as a source of estrogen analogues with a reduced risk profile. 相似文献
389.
Kevin A. Wilkinson Suzy M. Vasa Katherine E. Deigan Stefanie A. Mortimer Morgan C. Giddings Kevin M. Weeks 《RNA (New York, N.Y.)》2009,15(7):1314-1321
Hydroxyl-selective electrophiles, including N-methylisatoic anhydride (NMIA) and 1-methyl-7-nitroisatoic anhydride (1M7), are broadly useful for RNA structure analysis because they react preferentially with the ribose 2′-OH group at conformationally unconstrained or flexible nucleotides. Each nucleotide in an RNA has the potential to form an adduct with these reagents to yield a comprehensive, nucleotide-resolution, view of RNA structure. However, it is possible that factors other than local structure modulate reactivity. To evaluate the influence of base identity on the intrinsic reactivity of each nucleotide, we analyze NMIA and 1M7 reactivity using four distinct RNAs, under both native and denaturing conditions. We show that guanosine and adenosine residues have identical intrinsic 2′-hydroxyl reactivities at pH 8.0 and are 1.4 and 1.7 times more reactive than uridine and cytidine, respectively. These subtle, but statistically significant, differences do not impact the ability of selective 2′-hydroxyl acylation analyzed by primer extension-based (SHAPE) methods to establish an RNA secondary structure or monitor RNA folding in solution because base-specific influences are much smaller than the reactivity differences between paired and unpaired nucleotides. 相似文献