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51.
Comparing the shapes of regression functions 总被引:1,自引:0,他引:1
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GW Patton R Stephens IA Sidorov X Xiao RA Lempicki DS Dimitrov RH Shoemaker G Tudor 《BMC bioinformatics》2006,7(1):81
Background
Microarrays used for gene expression studies yield large amounts of data. The processing of such data typically leads to lists of differentially-regulated genes. A common terminal data analysis step is to map pathways of potentially interrelated genes. 相似文献55.
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RH Behrens Z Bisoffi A Björkman J Gascon C Hatz T Jelinek F Legros N Mühlberger P Voltersvik 《Malaria journal》2006,5(1):1-4
Background
Thick blood films are routinely used to diagnose Plasmodium falciparum malaria. Here, they were used to diagnose volunteers exposed to experimental malaria challenge.Methods
The frequency with which blood films were positive at given parasite densities measured by PCR were analysed. The poisson distribution was used to calculate the theoretical likelihood of diagnosis. Further in vitro studies used serial dilutions to prepare thick films from malaria cultures at known parasitaemia.Results
Even in expert hands, thick blood films were considerably less sensitive than might have been expected from the parasite numbers measured by quantitative PCR. In vitro work showed that thick films prepared from malaria cultures at known parasitaemia consistently underestimated parasite densities.Conclusion
It appears large numbers of parasites are lost during staining. This limits their sensitivity, and leads to erroneous estimates of parasite density. 相似文献57.
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Lauren RH Krumpe Kathryn M Schumacher James B McMahon Lee Makowski Toshiyuki Mori 《BMC biotechnology》2007,7(1):65