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Huntington''s chorea in Michigan. I. Demography and genetics 总被引:17,自引:0,他引:17
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MEI‐TING WANG YU‐CHENG HSU CHENG‐TE YAO SHOU‐HSIEN LI 《Molecular ecology resources》2005,5(2):439-442
From a partial genomic library enriched for GATA short tandem repeats, we developed 12 polymorphic microsatellite loci from the green‐backed tit (Parus monticolus). We characterized these loci by genotyping 30 adult individuals with unknown relationship. The number of alleles ranged from four to 17 per locus (mean = 9.3 alleles) and the observed heterozygosity for each locus ranged from 0.633 to 0.933 (mean = 0.789). All loci conformed to Hardy–Weinberg expectations. Four of 66 possible pairwise comparisons between loci showed significant gametic disequilibrium. 相似文献
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BP ONeill TM Habermann TE Witzig M Rodriguez 《Cancer immunology, immunotherapy : CII》1999,16(3):211-215
Five patients at risk for primary central nervous system lymphoma (PCNSL) recurrence were treated with high-dose methylprednisolone,
(HDMP) to prevent ‘trafficking’ of malignant lymphocytes into the central nervous system (CNS). HDMP was chosen because of
its ability to stabilize the ‘blood brain barrier (BBB)’. Three men with newly diagnosed PCNSL, ages 62, 76 and 78 y, whose
survival was projected to be 6.6 months, began treatment after achieving complete response (CR) to initial radiation therapy
alone and survived 27, 37 and 59 months after treatment. In none was death from recurrent disease in CNS but one patient did
die of systemic non-Hodgkin’s lymphoma (NHL) five years after PCNSL diagnosis. A 20 y old man was treated with HDMP after
successful combined modality therapy and is alive 75+months after initial diagnosis without evidence of disease recurrence.
A 34 y old man relapsed after combined modality initial treatment and failed to respond to HDMP when treatment was begun after
unsuccessful salvage therapy; he died of disease 12 months after initial diagnosis. There were no treatment complications.
The promising results in this pilot study from the basis for a North Central Cancer Treatment Group (NCCTG) 96-73-51, a Phase
2 clinical trial of brain radiotherapy and HDMP for PCNSL patients 70 y of age and older, a group of patients at high risk
for toxicity from intensive combined modality therapy. 相似文献
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Abstract: An assumption of mark-recapture studies is that the marker has no effect on the animal. Neck bands have been used extensively for goose research, but there has long been concern that they may have negative effects on some demographic parameters, and recent studies have yielded contradictory results. We evaluated the effects of neck bands on adult female greater snow geese (Chen caerulescens atlantica) by contrasting breeding propensity and apparent survival of geese marked with both a plastic neck band and a metal leg band and those marked solely with metal leg bands over an 11-year period on Bylot Island, Nunavut Territory, Canada. The use of multistate mark-recapture models also allowed us to estimate neck band loss and to obtain survival and capture probabilities that were not biased by such loss. Finally, we tested the effects of neck bands on other reproductive parameters (laying date, clutch size and nest success) over a 3-year period. Neck-banded females had decreased clutch size and capture probabilities, but their apparent survival rate, nest initiation and hatching dates, and nest survival were not affected compared to leg-banded only or unbanded females. Breeding propensity, indexed by capture probabilities of neck-banded females was, on average, 48% lower that that of leg-banded-only females but clutch size was only 10% lower. Neck band loss of females was low in this population (3% per year). We urge researchers to be cautious in the use of neck bands for estimation of population parameters and that the potential negative effects of neck bands be assessed as it is likely to be species-specific. 相似文献
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