首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   99186篇
  免费   7369篇
  国内免费   7314篇
  2024年   149篇
  2023年   1203篇
  2022年   3176篇
  2021年   5215篇
  2020年   3482篇
  2019年   4375篇
  2018年   4261篇
  2017年   3073篇
  2016年   4336篇
  2015年   6236篇
  2014年   7398篇
  2013年   7751篇
  2012年   9177篇
  2011年   8398篇
  2010年   4847篇
  2009年   4536篇
  2008年   5206篇
  2007年   4493篇
  2006年   3848篇
  2005年   3098篇
  2004年   2523篇
  2003年   2286篇
  2002年   1835篇
  2001年   1592篇
  2000年   1445篇
  1999年   1538篇
  1998年   895篇
  1997年   981篇
  1996年   870篇
  1995年   820篇
  1994年   714篇
  1993年   608篇
  1992年   726篇
  1991年   572篇
  1990年   491篇
  1989年   359篇
  1988年   301篇
  1987年   234篇
  1986年   209篇
  1985年   229篇
  1984年   132篇
  1983年   128篇
  1982年   57篇
  1981年   24篇
  1980年   22篇
  1979年   19篇
  1976年   1篇
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
131.
X-ray absorption spectroscopic (XAS) studies on cytochrome C1 from beef heart mitochondria were conducted to identify the effect of the hinge protein [Kim, C.H., & King, T.E. (1983) J. Biol. Chem. 258, 13543-13551] on the structure of the heme site in cytochrome c1. A comparison of XAS data of highly purified "one-band" and "two-band" cytochrome c1 [Kim, C.H., & King, T.E. (1987) Biochemistry 26, 1955-1961] demonstrates that the hinge protein exerts a rather pronounced effect on the heme environment of the cytochrome c1: a conformational change occurs within a radius of approximately 5 A from the heme iron in cytochrome c1 when the hinge protein is bound to cytochrome c1. This result may be correlated with the previous observations that the structure and reactivity of cytochrome c1 are affected by the hinge protein [Kim, C.H., & King, T.E. (1987) Biochemistry 26, 1955-1961; Kim, C.H., Balny, C., & King, T.E. (1987) J. Biol. Chem. 262, 8103-8108].  相似文献   
132.
133.
134.
Nucleotide sequence of rice waxy gene.   总被引:21,自引:0,他引:21       下载免费PDF全文
  相似文献   
135.
转化生长因子β   总被引:3,自引:0,他引:3  
张平 《生理科学进展》1990,21(4):323-328
TGFβ广泛存在于动物体多种组织和细胞内,由二条相同的、含112个氨基酸的肽链组成,是细胞的多功能双重调节因子。它对不同组织类型的细胞,可促进生长、分化,也可抑制生长、分化,并直接参与组织修复、胚胎发育等过程,调节细胞外基质形成。  相似文献   
136.
The effects of ethephon on stomatal resistance, water potential, osmotic potential, turgor potential, and ethylene production were determined on leaves of a drought-resistant (KS 65) and a drought-sensitive (IA 25) genotype of sorghum [Sorghum bicolor (L.) Moench] grown under wellwatered or drought-stressed conditions. With both sufficient and limited water supply, ethephon had no effect on the adaxial, abaxial, or total stomatal resistance of either genotype. For both water treatments, the adaxial stomatal resistance of the drought-sensitive genotype was higher than that of the drought-resistant genotype. Ethephon increased the amount of ethylene produced by the plants under both levels of water. For plants with sufficient water, water potentials of both genotypes were lowered by ethephon. Ethephon had no effect on the water potentials under drought or on the osmotic potentials under either water regime. With drought, the turgor potential of the drought-sensitive genotype, but not that of the drought-resistant, was increased by ethephon.  相似文献   
137.
D-beta-Hydroxybutyrate dehydrogenase (BDH), a lipid-requiring enzyme, has been purified to homogeneity from rat brain using a new improved method. The purified rat brain BDH has a subunit molecular mass of 31 kilodaltons on sodium dodecyl sulphate-polyacrylamide gel electrophoresis. The apoenzyme, i.e., the enzyme devoid of phospholipid, has no activity, but can be activated by phospholipid to a specific activity of 125 mumol/(min.mg). This is 625-fold greater than the activity in the mitochondrial fraction. The new purification procedure involves chromatography using a quaternary amine Sepharose resin followed by a sulphonate Sepharose resin, and eliminates the need for glass bead adsorption chromatography.  相似文献   
138.
139.
Studies in the field and in a greenhouse were conducted to examine the effects of sand burial on seed germination, seedling emergence and establishment of Panicum virgatum L. on the foredunes of Lake Erie. Under natural conditions, the seedlings emerged from sand burial depths ranging from 0 to 11 cm, with a mean ± SD of 4.73 ± 1.82 cm. The frequency distribution of the depth of emergence of seedlings in the field was significantly skewed to the right and platykurtic. In the greenhouse, some seedlings emerged from a burial depth of as much as 16 cm. Although percent germination of seeds was not affected by sand burial, the percent emergence and the rate of emergence of seedlings were significantly reduced by excessive sand burial. Seedling mortality was found only among seedlings that emerged from sand burial depths of 10 cm or more. In the field, all the seedlings established in one growing season had originally emerged from sand burial depths of less than 12 cm. Within this burial range, seedlings from shallower burial depths had lower chances of establishment than expected, whereas those from deeper burial depths had higher probabilities of establishment than expected.  相似文献   
140.
Role of oxidatively modified LDL in atherosclerosis   总被引:32,自引:0,他引:32  
Oxidative modification of LDL is accompanied by a number of compositional and structural changes, including increased electrophoretic mobility, increased density, fragmentation of apolipoprotein B, hydrolysis of phosphatidylcholine, derivatization of lysine amino groups, and generation of fluorescent adducts due to covalent binding of lipid oxidation products to apo B. In addition, oxidation of LDL has been shown to result in numerous changes in its biologic properties that could have pathogenetic importance, including accelerated uptake in macrophages, cytotoxicity, and chemotactic activity for monocytes. The present article summarizes very recent developments related to the mechanism of oxidation of LDL by cells, receptor-mediated uptake of oxidized LDL in macrophages, the mechanism of phosphatidylcholine hydrolysis during LDL oxidation, and other biologic actions of oxidized LDL including cytotoxicity, altered eicosanoid metabolism, and effects on the secretion of growth factors and chemotactic factors. In addition, this review will examine the evidence for the presence of oxidized LDL in vivo and the evidence that oxidized LDL plays a pathogenetic role in atherosclerosis.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号