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111.
Nighat Nazir Surrinder Koul Mushtaq Ahmad Qurishi Subhash Chandra Taneja Ghulam Nabi Qazi 《Biocatalysis and Biotransformation》2013,31(2):118-123
The regioselective acylation of irilone, isolated from Iris germanica, with vinylacetate and propenylacetate and deacylation of irilone diacetate with n-butanol were studied using lipases from Aspergillus niger, Mucor miehei, Pseudomonas cepacia, Candida cylindracea, porcine pancreas and Candida antarctica. Significant conversion of irilone to 4′-O-acetylirilone was achieved using P. cepacia lipase, while irilone diacetate was converted to 5-O-acetylirilone by the enzymatic action of lipases from M. miechei, P. cepacia and porcine pancreas under different experimental conditions. This preferential protection/deprotection furnishes an opportunity to modify the structure of irilone by selective derivatization that may help to change its biological activities by modifying its amphiphilic/lipophilic balance. 相似文献
112.
Hasan Muhammad A. Shahid Hira Khan Hashim R. Qazi Saad A. Fraser Matthew 《Applied psychophysiology and biofeedback》2021,46(2):183-194
Applied Psychophysiology and Biofeedback - Neurofeedback (NF) training based on alpha upregulation has been widely used on patient and healthy populations. However, active voluntary modulation of... 相似文献
113.
Background
Human sexual orientation is influenced by genetic and non-shared environmental factors as are two important psychological correlates – childhood gender typicality (CGT) and adult gender identity (AGI). However, researchers have been unable to resolve the genetic and non-genetic components that contribute to the covariation between these traits, particularly in women.Methodology/Principal Findings
Here we performed a multivariate genetic analysis in a large sample of British female twins (N = 4,426) who completed a questionnaire assessing sexual attraction, CGT and AGI. Univariate genetic models indicated modest genetic influences on sexual attraction (25%), AGI (11%) and CGT (31%). For the multivariate analyses, a common pathway model best fitted the data.Conclusions/Significance
This indicated that a single latent variable influenced by a genetic component and common non-shared environmental component explained the association between the three traits but there was substantial measurement error. These findings highlight common developmental factors affecting differences in sexual orientation. 相似文献114.
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117.
WM. G. Moore 《The Western journal of medicine》1921,19(9):362-363
118.
119.
Sumbul Firdaus Anupam Dhasmana Vandana Srivastava Tasneem Bano Afreen Fatima Qazi Mohammad Sajid Jamal Roshan Jahan Gulshan Wadhwad Mohtashim Lohani 《Bioinformation》2015,11(3):122-126
Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications which has
opened wide venues for possible human exposure to various fullerene types. Therefore, in depth knowledge of how fullerene may
interfere with various cellular processes becomes quite imperative. The present study was designed to investigate how the
presence of fullerene affect the binding of DNA with different enzymes involved in replication process. Different fullerenes were
first docked with DNA and then binding scores of different enzymes was analyzed with fullerene docked DNA. C30, C40 & C50
once docked with DNA, reduced the binding score of primase, whereas no significant change in the binding score was observed
with the helicase, ssb protein, dna pol δ, dna pol ε, ligase, DNA clamp, and topoisomerases. On the contrast, the binding score of
RPA14 decreases in fluctuating manner while interacting with increasing molecular weight of fullerene bound single-stranded
DNA complex. The study revealed the affect of fullerene family interacting with DNA on the binding pattern of enzymes involved
in replication process. Study suggests that the presence of most of fullerenes may not affect the activity of these enzymes necessary
for replication process whereas C30, C40 & C50 may disrupt the activity of primase, (strating point for DNA polymerase) its
docking score decreases from 13820 to 10702. 相似文献
120.
I Saba PH Qazi SA Rather RA Dar QA Qadri N Ahmad S Johri SC Taneja S Shawl 《World journal of microbiology & biotechnology》2012,28(3):1071-1079
A Psychrotolerant alkaline protease producing bacterium IIIM-ST045 was isolated from a soil sample collected from the Thajiwas
glacier of Kashmir, India and identified as Stenotrophomonas sp. on the basis of its biochemical properties and 16S ribosomal gene sequencing. The strain could grow well within a temperature
range of 4–37°C however, showed optimum growth at 15°C. The strain was found to over-produce proteases when it was grown in
media containing lactose as carbon source (157.50 U mg−1). The maximum specific enzyme activity (398 U mg−1) was obtained using soya oil as nitrogen source, however, the inorganic nitrogen sources urea, ammonium chloride and ammonium
sulphate showed the lowest production of 38.9, 62.2 and 57.9 U mg−1. The enzyme was purified to 18.45 folds and the molecular weight of the partially purified protease was estimated to be ~55 kDa
by SDS-PAGE analysis. The protease activity increased as the increase in enzyme concentration while as the optimum enzyme
activity was found when casein (1% w/v) was used as substrate. The enzyme was highly active over a wide range of pH from 6.5
to 12.0 showing optimum activity at pH 10.0. The optimum temperature for the enzyme was 15°C. Proteolytic activity reduced
gradually with higher temperatures with a decrease of 56% at 40°C. The purified enzyme was checked for the removal of protein
containing tea stains using a silk cloth within a temperature range of 10–60°C. The best washing efficiency results obtained
at low temperatures indicate that the enzyme may be used for cold washing purposes of delicate fabrics that otherwise are
vulnerable to high temperatures. 相似文献