全文获取类型
收费全文 | 11621篇 |
免费 | 1122篇 |
国内免费 | 1779篇 |
出版年
2024年 | 42篇 |
2023年 | 198篇 |
2022年 | 374篇 |
2021年 | 581篇 |
2020年 | 449篇 |
2019年 | 536篇 |
2018年 | 529篇 |
2017年 | 414篇 |
2016年 | 518篇 |
2015年 | 739篇 |
2014年 | 948篇 |
2013年 | 957篇 |
2012年 | 1148篇 |
2011年 | 1043篇 |
2010年 | 657篇 |
2009年 | 610篇 |
2008年 | 698篇 |
2007年 | 598篇 |
2006年 | 601篇 |
2005年 | 437篇 |
2004年 | 381篇 |
2003年 | 326篇 |
2002年 | 249篇 |
2001年 | 133篇 |
2000年 | 126篇 |
1999年 | 95篇 |
1998年 | 106篇 |
1997年 | 70篇 |
1996年 | 68篇 |
1995年 | 58篇 |
1994年 | 58篇 |
1993年 | 40篇 |
1992年 | 62篇 |
1991年 | 46篇 |
1990年 | 57篇 |
1989年 | 46篇 |
1988年 | 36篇 |
1987年 | 30篇 |
1986年 | 29篇 |
1985年 | 33篇 |
1984年 | 46篇 |
1983年 | 30篇 |
1982年 | 34篇 |
1981年 | 42篇 |
1980年 | 24篇 |
1979年 | 24篇 |
1978年 | 20篇 |
1977年 | 23篇 |
1975年 | 23篇 |
1973年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Interference of GSM mobile phones with communication between Cardiac Rhythm Management devices and programmers: A combined in vivo and in vitro study
下载免费PDF全文
![点击此处可从《Bioelectromagnetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
992.
Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sexrelated behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days(twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the samesex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and self-grooming behaviors in females; in contrast, these effects were not found in males. These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males. 相似文献
993.
【目的】非编码RNA(non-coding RNA,ncRNA)在家蚕Bombyx mori发育过程中具有重要调控作用。本研究旨在探索ncRNA参与家蚕神经系统发育的分子机理。【方法】采用实时荧光定量PCR技术对22个中等长度的ncRNA及3个ncRNA的邻近编码基因在家蚕幼虫神经系统中的表达水平进行检测。【结果】8个ncRNA(包括1个C/D box snoRNA,4个H/ACA box snoRNA和3个不能归类的ncRNA)在家蚕5龄幼虫神经组织和非神经组织中均有表达,且在胸腹神经中的表达量明显高于头部神经中的表达量。其中,snoRNA Bm-51,Bm-18和Bm-86在胸腹神经中的表达量分别是头部神经中的23,5和4.7倍。进一步研究发现,这3个内含子起源的ncRNA与其宿主基因在家蚕神经系统中的表达趋势一致,宿主基因在胸腹神经中的表达量也明显高于头部神经中的表达量。【结论】本研究筛选到的在家蚕不同神经部位存在差异表达的ncRNA,特别是在胸腹神经中高表达的ncRNA可能协同其邻近编码基因,参与家蚕神经发育或神经活动过程。该结果为研究ncRNA参与家蚕神经系统发育提供了分子依据,为从非编码RNA角度探索鳞翅目害虫防治提供了新的思路。 相似文献
994.
Kim Bo Kyung Joo HuiTae Song Ho Jung Yang Eun Jin Lee Sang Hoon Hahm Doshik Rhee Tae Siek Lee Sang H. 《Polar Biology》2015,38(3):319-331
Polar Biology - To better estimate annual primary production in the Amundsen Sea, which is one of the highest productivity regions in the Southern Ocean, the seasonal variations in carbon and... 相似文献
995.
Bo Yong Kim Hwa Young Song Mi Young Kim Bong Hee Lee Kyung Joo Kim Kyung Jin Jo Suhng Wook Kim Seung Gwan Lee Boo Hyung Lee 《Archives of insect biochemistry and physiology》2015,89(3):169-180
Despite numerous studies on late embryogenesis abundant (LEA) proteins, their functions, roles, and localizations during developmental stages in arthropods remain unknown. LEA proteins protect crucial proteins against osmotic stress during the development and growth of various organisms. Thus, in this study, fluorescence in situ hybridization was used to determine the crucial regions protected against osmotic stress as well as the distinctive localization of group 3 (G3) LEA+ cells during brine shrimp development. Several cell types were found to synthesize G3 LEA RNA, including neurons, muscular cells, APH‐1+ cells, and renal cells. The G3 LEA+ neuronal cell bodies outside of the mushroom body projected their axonal bundles to the central body, but those inside the mushroom body projected their axonal bundles toward the deutocerebrum without innervating the central body. The cell bodies inside the mushroom body received axons of the G3 LEA+ sensory cells at the medial ventral cup of the nauplius eye. Several glands were found to synthesize G3 LEA RNA during the nauplius stages of brine shrimp, including the sinus, antennal I and II, salt, and three ectodermal glands. This study provides the first demonstration of the formation of G3 LEA+ sinus glands at the emergence stages of brine shrimp. These results suggest that G3 LEA protein is synthesized in several cell types. In particular, specific glands play crucial roles during the emergence and nauplius stages of brine shrimp. 相似文献
996.
997.
Jing Yu Yun Kong Suqin Gao Lihong Miao Pei Zou Bo Xu Chi Zeng Xiaolin Zhang 《Journal of applied phycology》2015,27(3):1213-1221
998.
Post‐dispersal seed predation and its relations with seed traits: a thirty‐species‐comparative study
下载免费PDF全文
![点击此处可从《Plant Species Biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Post‐dispersal seed predation is a key process determining the variability in seed survival in forests, where most seeds are handled by rodents. Seed predation is thought to affect seedling regeneration, colonization ability and spatial distribution of plants. Basic seed traits are the essential factors affecting rodent foraging preferences and thus seed survival and seedling recruitment. Many studies have discussed several seed traits and their effects upon seed predation by rodents. However, the results of those previous studies are usually equivocal, likely because few seed traits and/or plant species tend to be incorporated into these studies. In order to elucidate the relationships between seed predation and seed traits, we surveyed the predation of 48 600 seeds in a natural pine forest, belonging to 30 species, for three consecutive years. The results demonstrated that: (i) seed size and seed coat hardness did not significantly affect seed predation; (ii) total phenolics had a negative effect upon seed predation; (iii) positive effects of nitrogen content upon seed predation were found. From our study, it seems that the better strategy to prevent heavy predation is for plants to produce seeds with higher total phenolics content rather than physical defenses (i.e. hard seed coat) or larger seeds. Additionally, rodent foraging preference may depend more on Nitrogen content than other nutrient content of seeds. 相似文献
999.
Apoptotic and autophagic pathways with relevant small‐molecule compounds,in cancer stem cells
下载免费PDF全文
![点击此处可从《Cell proliferation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lan Zhang Xupeng Tong Jingjing Li Yue Huang Xinyue Hu Yi Chen Jian Huang Jinhui Wang Bo Liu 《Cell proliferation》2015,48(4):385-397
Accumulating evidence demonstrates existence of cancer stem cells (CSCs), which are suspected of contributing to cancer cell self‐renewal capacity and resistance to radiation and/or chemotherapy. Including evasion of apoptosis and autophagic cell death, CSCs have revealed abilities to resist cell death, making them appealing targets for cancer therapy. Recently, molecular mechanisms of apoptosis and of autophagy in CSCs have been gradually explored, comparing them in stem cells and in cancer cells; distinct expression of these systems in CSCs may elucidate how these cells exert their capacity of unlimited self‐renewal and hierarchical differentiation. Due to their proposed ability to drive tumour initiation and progression, CSCs may be considered to be potentially useful pharmacological targets. Further, multiple compounds have been verified as triggering apoptosis and/or autophagy, suppressing tumour growth, thus providing new strategies for cancer therapy. In this review, we summarized regulation of apoptosis and autophagy in CSCs to elucidate how key proteins participate in control of survival and death; in addition, currently well‐studied compounds that target CSC apoptosis and autophagy are selectively presented. With increasing attention to CSCs in cancer therapy, researchers are now trying to find responses to unsolved questions as unambiguous as possible, which may provide novel insight into future anti‐cancer regimes. 相似文献
1000.
Reticulate evolution and sea‐level fluctuations together drove species diversification of slipper orchids (Paphiopedilum) in South‐East Asia
下载免费PDF全文
![点击此处可从《Molecular ecology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
South‐East Asia covers four of the world's biodiversity hotspots, showing high species diversity and endemism. Owing to the successive expansion and contraction of distribution and the fragmentation by geographical barriers, the tropical flora greatly diversified in this region during the Tertiary, but the evolutionary tempo and mode of species diversity remain poorly investigated. Paphiopedilum, the largest genus of slipper orchids comprising nearly 100 species, is mainly distributed in South‐East Asia, providing an ideal system for exploring how plant species diversity was shaped in this region. Here, we investigated the evolutionary history of this genus with eight cpDNA regions and four low‐copy nuclear genes. Discordance between gene trees and network analysis indicates that reticulate evolution occurred in the genus. Ancestral area reconstruction suggests that vicariance and long‐distance dispersal together led to its current distribution. Diversification rate variation was detected and strongly correlated with the species diversity in subg. Paphiopedilum (~80 species). The shift of speciation rate in subg. Paphiopedilum was coincident with sea‐level fluctuations in the late Cenozoic, which could have provided ecological opportunities for speciation and created bridges or barriers for gene flow. Moreover, some other factors (e.g. sympatric distribution, incomplete reproductive barriers and clonal propagation) might also be advantageous for the formation and reproduction of hybrid species. In conclusion, our study suggests that the interplay of reticulate evolution and sea‐level fluctuations has promoted the diversification of the genus Paphiopedilum and sheds light into the evolution of Orchidaceae and the historical processes of plant species diversification in South‐East Asia. 相似文献