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对55名Y染色体具有形态上相同的、异染色质几乎全部缺失的男性和55名Y染色体正常的男性进行了80项形态生理学性状的研究。发现在这两个组之间大部分性状的平均值并无显著性差异,但有些血液学指标有显著差异。用模式认辨法确定出20个性状的组合可以区分这两个组,其认辨误差为4.6%。认辨系统包括的有价值的性状为心电图指标(占性状的25%)、某些人类学指标、血液学指标和个体年龄。结果表明,Y染色体异染色质可能在人的个体发育过程中对形态生理学性状间的表型关系起一种修饰作用。 相似文献
54.
The sex, age, tribal, and surname compositions of the populations of three villages of Altai Republic, Kulada (Ongudaisk raion), Beshpeltir (Chemal raion), and Kurmach-Baigol (Turochak raion) have been studied. Altaian populations are characterized by a high proportion of persons under 20 years of age (35.3-46.1%); however, there is a tendency towards a narrow base of the sex-age pyramid. The sex ratios in the total populations and in individual age groups are unfavorable. The rural populations studied differ in the spectrum and pattern of surname accumulation. The Kurmach-Baigol population (which consists of Northern Altaians) considerably differs from the Beshpeltir and Kulada populations (which are mostly Southern Altaian) with respect to the calculated parameters characterizing the population structure (random isonymy, migration index, the parameter of tribe diversity, entropy, and the redundancy of surname distribution). Isonymy coefficients of relationship between individual populations have been calculated from the data on tribes (surnames). These coefficients for pairs of populations are the following: for the Beshpeltir and Kulada populations, 0.3035938 (0.0000443 and 0.0000378 for the Altaian and total populations, respectively); for the Beshpeltir and Kurmach-Baigol populations, 0.0026788 (0.0000172 and 0.0000121 for the Altaian and total populations, respectively); and for the Kulada and Kurmach-Baigol populations, 0.0054811 (no common surnames have been found). 相似文献
55.
The dynamics of population marriage structure in the period from 1951 to 1997 has been studied in three villages of Altai Republic: Kulada (Ongudaisk raion), Beshpeltir (Chemal raion), and Kurmach-Baigol (Turochak raion). These populations have been found to differ from one another in the intensity and direction of migration, as well a its temporal pattern with respect to the birthplaces and ethnicity of persons contracting marriages. Periods of active incorporation of non-Altaian (mostly Slavic) ethnic components into the gene pools of the Beshpeltir and Kurmach-Baigol populations have been detected. The geographic distributions of the birthplaces of men and women contracting marriages are different. Therefore, migration has different effects on the genetic diversity of the Y-chromosomal and mitochondrial-DNA pools. No isonymic marriages have been found in the Altaian populations studied; however, an increase in the random component of inbreeding has been observed. 相似文献
56.
ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans 总被引:2,自引:0,他引:2
Makeeva OA Puzyrev KV Pavliukova EN Koshel'skaia OA Golubenko MV Efimova EV Kucher AN Tsimbaliuk IV Karpov RS Puzyrev VP 《Molekuliarnaia biologiia》2004,38(6):990-996
The role of A2350G polymorphism in exon 17 of the ACE gene and A1166C - in 3'-UTR of the AGTR1 in the pathogenesis of left ventricular hypertrophy was studied in patients with essential hypertension (EH) and arterial hypertension combined with diabetes mellitus type 2 (AH + DM2). Patients with EH and AH + DM2 did not differ from the control sample of healthy individuals by allele or genotype frequencies. However, an association of both polymorphisms with LVH was detected in EH patients. The frequency of 1166C allele was higher in patients with LVH (33.6% vs 20.7% without LVH). A1166C polymorphism determined the magnitude of left ventricular mass index (LVMI) in EH patients as well (p = 0.007). 2350G allele frequency of the ACE gene was in 1.5, and GG genotype--in 3.5-fold higher in EH patients with LVH, as compared without LVH. LVMI was significantly higher in patients with GG genotype as compared with heterozygotes and AA homozygotes (p = 0.002). Thus the presence of 1166C allele of AGTR1 and 2350G allele of ACE can be considered as predisposing factors for LVH development in EH. In contrast, association of studied polymorphisms with presence or LVH degree was not detected in patients with arterial hypertension combined with DM2. This may indicate another structure of genetic component of predisposition to LVH in different causes. 相似文献
57.
Puzyrev VF Drevtsova IN Burkov AN Ulanova TI 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》2004,(6):76-80
The plasmid construction expressing recombinant HBc antigen (HbcAg) in Escherichia coli cells under the control of the PL promoter of phage I, was obtained. The specific activity of the antigen thus obtained was controlled by the enzyme immunoassay (EIA) method and compared with the reference system "AxSYM CORE assay" ("Abbott", USA) with four panels of sera (altogether 111 samples). The coincidence of the results of the compared test system with the reference was 96.4%, which made it possible to recommend this genetic construction of recombinant HBcAg for the production of EIA systems. 相似文献
58.
This article is a review of scientific publications, in which issues of pathogenetics of multifactorial diseases (MFDs) are
considered from the viewpoint of evolution and ontogeny. Concepts explaining significance of evolutionary processes in the
formation of genetic architecture of human chronic diseases (“thrifty” genomes and phenotypes, “drifty genes,” decanalization)
are analyzed. The roles of natural selection and genetic drift in the formation of hereditary diversity of genes for susceptibility
to MFDs are considered. The modern concept of “disease ontogeny” (somatic mosaicism, loss of heterozygosity, paradominant
inheritance, epigenetic variability) is discussed. It is demonstrated that the evolutionary and ontogenetic approaches to
analysis of genimuc and other “-omic” data are essential for understanding the biology of diseases. 相似文献
59.
Vasin B. L. Mal’kova S. V. Osipov M. V. Puzyrev V. N. Saakyan A. T. Starodub A. N. Fedotov S. I. Fronya A. A. Shutyak V. G. 《Plasma Physics Reports》2010,36(13):1255-1260
The optical scheme and design of a four-frequency polarizing microscope intended for simultaneous recording of plasma images
in the wavelength range 0.4–1.1 μm with the spatial resolution 12 μm in the entire spectral range are described. The effectiveness
of such a microscope in studies of plasmas produced on interaction of laser radiation with a target is demonstrated. The plasma
images are obtained at the frequencies ω0, (3/2)ω0, 2ω0, and (5/2)ω0, where ω0 corresponds to the frequency of heating radiation. The transformation coefficient that characterizes the efficiency of conversion
of heating radiation into the 2ω0, (3/2)ω0, and (5/2)ω0 harmonics generated in the plasma is determined. 相似文献
60.
Larisa M. Skobeltsyna Dmitrii V. Pyshnyi Eugenia M. Ivanova Vadim A. Stepanov Valery P. Puzyrev Grigory M. Dymshits Vladimir N. Kharkov Valentina F. Zarytova 《Molecular biotechnology》2010,45(1):1-8
We propose a novel universal methodology, Short Oligonucleotide Tandem Ligation Assay (SOTLA), for SNP genotyping. SOTLA is
based on using a tandem of short oligonucleotide (TSO) probes consisting of three fragments: the core oligonucleotide and
two flanking oligomers, one of which is immobilized onto a solid support and another one contains the biotin label. TSO is
self-associated on a complementary DNA template, forms the complex containing two nicks, which are efficiently ligated with
DNA ligase giving biotinylated oligonucleotide covalently bound to polymer beads. No ligation of TSO on an imperfect DNA template
bearing the base substitution in the core binding site is occurred. We used SOTLA for the highly selective SNP analysis in
different DNA fragments of human Y chromosome. Comparison of SOTLA results with those of PCR-RFLP and allele-specific PCR
techniques demonstrates that SOTLA ensures the univocal reliable SNP analysis in different PCR fragments varying in length
and base composition. The fundamental difference between SOTLA and well known OLA approaches while using T4 DNA ligase is
that the accuracy of SNP analysis in OLA is ensured only by the specificity of ligase while that in SOTLA is provided by the
specificity of both ligation and hybridization of TSO probes. 相似文献