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101.
The trk family of tyrosine protein kinase receptors. 总被引:7,自引:0,他引:7
102.
Post‐dispersal seed predation is a crucial phenomenon for plant recruitment, and its incidence can be hypothesized to increase in ecologically and geographically marginal populations of threatened species, such as yew (Taxus baccata). Here we examine the among‐ and within‐population patterns of seed consumption by rodents and evaluate to what extent they are linked to marginality in Mediterranean low‐density yew stands. Among populations we tested: (i) whether the rates of seed predation found in our marginal sites were consistently higher than in populations from core regions; (ii) within populations we evaluated whether rodents preferred microhabitats with greater seed availability (beneath female yew trees) or with lower predation risk (shrubs) in two seeding seasons (fall–winter 2005 and 2006). Predation rates were extremely high (92.5%) and they were well above values reported for core populations (65.4%), to the extent that rodents almost completely depleted the experimental seeds in all populations and years. Our expectation of lower predation rates with decreasing vegetation cover was also confirmed for all years and populations, suggesting that rodent foraging was risk‐sensitive. This microhabitat effect outweighed the effect of seed availability under female yew trees, implying also that rodents selectively consumed the most valuable seeds in terms of their recruitment prospects. Overall, our results suggest that the mechanisms underlying seed depletion and its demographic consequences are linked to the effects of reduced yew performance in ecologically marginal habitats. 相似文献
103.
Josep Garre-Olmo Margarita Flaqué Jordi Gich Teresa Osuna Pulido Josefina Turbau Natalia Vallmajo Marta Vi?as Secundí López-Pousa Registry of Dementia of Girona Study Group 《BMC neurology》2009,9(1):5
Background
Traditional epidemiological studies do not allow elucidating the reality of referral and diagnosis patterns of dementia in routine clinical practice within a defined territory. This information is useful and necessary in order to plan and allocate healthcare resources. This paper presents the results from a dementia case registry based on epidemiological surveillance fundamentals. 相似文献104.
105.
Herein a new method that allows binding DeltaCp to be determined with a single experiment is presented. Multithermal titration calorimetry (MTC) is a simple extension of isothermal titration calorimetry (ITC) that explicitly takes into account the thermal dependences of DeltaH and the binding constant. Experimentally, this is accomplished by performing a single stepwise titration with ITC equipment, allowing temperature re-adjustments of the system at intermediate states of the titration process. Thus, from the resulting multitherm, DeltaCp can also be determined. The experimental feasibility of MTC was tested by using the well-characterized lysozyme-chitotriose complex as a model system. 相似文献
106.
A novel haplo-identical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation 总被引:1,自引:0,他引:1
Michael Uhlin Mantas Okas Jens Gertow Mehmet Uzunel Torkel B. Brismar Jonas Mattsson 《Cancer immunology, immunotherapy : CII》2010,59(3):473-477
Epstein–Barr virus (EBV)-related malignancies such as post-transplant lymphoproliferative disease (PTLD) are severe complications
after allogeneic stem cell transplantation and solid-organ transplantation. In immunosuppressed transplant recipients, the
activity of EBV-specific CTLs are often decreased or absent which leads to an increased risk of developing PTLD. If primary
treatment modalities of PTLD fail, the most efficient way of treating the malignancy is adopting EBV-specific CTLs from the
donor or, more recently, third-party donors. However, both are time consuming and expensive and often it is too late to administer
cells to the patient. We have for the first time, using a rapid isolation protocol of EBV-specific T cells, treated and cured
a patient suffering from PTLD with multiple-associated tissue lesions, using her haplo-identical mother as a donor. This treatment
approach paves way for a new possibility to within-days treat patients with life-threatening EBV-associated malignancies. 相似文献
107.
108.
Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism to steer normal development and physiological functioning of multicellular organisms. Phosphotyrosine dephosphorylation is exerted by members of the super-family of protein tyrosine phosphatase (PTP) enzymes and many play such essential roles that a wide variety of hereditary disorders and disease susceptibilities in man are caused by PTP alleles. More than two decades of PTP research has resulted in a collection of PTP genetic variants with corresponding consequences at the molecular, cellular and physiological level. Here we present a comprehensive overview of these PTP gene variants that have been linked to disease states in man. Although the findings have direct bearing for disease diagnostics and for research on disease etiology, more work is necessary to translate this into therapies that alleviate the burden of these hereditary disorders and disease susceptibilities in man. 相似文献
109.
Catalina Reyes‐Nivia Guillermo Diaz‐Pulido David Kline Ove‐Hoegh Guldberg Sophie Dove 《Global Change Biology》2013,19(6):1919-1929
Biological mediation of carbonate dissolution represents a fundamental component of the destructive forces acting on coral reef ecosystems. Whereas ocean acidification can increase dissolution of carbonate substrates, the combined impact of ocean acidification and warming on the microbioerosion of coral skeletons remains unknown. Here, we exposed skeletons of the reef‐building corals, Porites cylindrica and Isopora cuneata, to present‐day (Control: 400 μatm – 24 °C) and future pCO2–temperature scenarios projected for the end of the century (Medium: +230 μatm – +2 °C; High: +610 μatm – +4 °C). Skeletons were also subjected to permanent darkness with initial sodium hypochlorite incubation, and natural light without sodium hypochlorite incubation to isolate the environmental effect of acidic seawater (i.e., Ωaragonite <1) from the biological effect of photosynthetic microborers. Our results indicated that skeletal dissolution is predominantly driven by photosynthetic microborers, as samples held in the dark did not decalcify. In contrast, dissolution of skeletons exposed to light increased under elevated pCO2–temperature scenarios, with P. cylindrica experiencing higher dissolution rates per month (89%) than I. cuneata (46%) in the high treatment relative to control. The effects of future pCO2–temperature scenarios on the structure of endolithic communities were only identified in P. cylindrica and were mostly associated with a higher abundance of the green algae Ostreobium spp. Enhanced skeletal dissolution was also associated with increased endolithic biomass and respiration under elevated pCO2–temperature scenarios. Our results suggest that future projections of ocean acidification and warming will lead to increased rates of microbioerosion. However, the magnitude of bioerosion responses may depend on the structural properties of coral skeletons, with a range of implications for reef carbonate losses under warmer and more acidic oceans. 相似文献
110.
P. Spierenburg E. C. H. E. T. Lucassen C. Pulido A. J. P. Smolders J. G. M. Roelofs 《Plant biology (Stuttgart, Germany)》2013,15(6):955-962
During spring storms massive uprooting of Littorella uniflora occurred in a shallow Dutch softwater lake. The aim of this study was to test whether changes in plant morphology and sediment characteristics could explain the observed phenomenon. Uprooting was expected to occur in plants having a high shoot biomass and low root to shoot ratio (R:S), growing on sediments with a high organic matter content. Normally, uprooting of the relative buoyant L. uniflora is prevented by an extensive root system, expressed as a high R:S. This was studied by sampling floating and still rooted L. uniflora plants, as well as sediment and sediment pore water, along a gradient of increasing sediment organic matter content. Increasing organic matter content was related to increasing L. uniflora shoot biomass and consequently decreasing R:S. Furthermore, the results indicated that uprooting indeed occurred in plants growing on very organic sediments and was related to a low R:S. The increased shoot biomass on more organic sediments could be related to increased sediment pore water total inorganic carbon (TIC; mainly CO2) availability. Additionally, increased phosphorus availability could also have played a role. The disappearance of L. uniflora might lead to higher nutrient availability in the sediments. It is suggested that this could eventually promote the expansion of faster‐growing macrophytes. 相似文献