全文获取类型
收费全文 | 449篇 |
免费 | 52篇 |
出版年
2021年 | 5篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 15篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 14篇 |
2009年 | 12篇 |
2008年 | 21篇 |
2007年 | 10篇 |
2006年 | 13篇 |
2005年 | 16篇 |
2004年 | 13篇 |
2003年 | 17篇 |
2002年 | 11篇 |
2001年 | 18篇 |
2000年 | 14篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1995年 | 4篇 |
1994年 | 11篇 |
1993年 | 3篇 |
1992年 | 16篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 10篇 |
1973年 | 7篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 5篇 |
1968年 | 5篇 |
1967年 | 10篇 |
1966年 | 5篇 |
1964年 | 5篇 |
1937年 | 3篇 |
排序方式: 共有501条查询结果,搜索用时 31 毫秒
71.
72.
73.
74.
75.
An important recent advance in the understanding of vertebrate photoreceptor light adaptation has come from the discovery that as many as eight distinct molecular mechanisms may be involved, and the realization that one of the principal mechanisms is not dependent on calcium. Quantitative analysis of these mechanisms is providing new insights into the nature of rod photoreceptor light adaptation. 相似文献
76.
D. J. Marshall N. J. M. Gremmen L. Coetzee B. M. O’Connor P. J. A. Pugh P. D. Theron E. A. Ueckermann 《Polar Biology》1999,21(2):84-89
Sixty species of Acari are recorded from the sub-Antarctic Marion and Prince Edward Islands (the Prince Edward archipelago).
Twenty of the 45 species collected on recent expeditions are new and currently undescribed. Other new taxa include a family
of Mesostigmata, four new genera, and the first sub-Antarctic records of Cillibidae (Mesostigmata) and Eryngiopus (Prostigmata). Fifteen of the 31 species previously reported from the islands are confirmed, although eight of the previous
accounts remain doubtful. The fauna, which shows a distinction between the shoreline and terrestrial components, comprises
endemic, South Indian Ocean Province and sub-Antarctic mite species.
Accepted: 18 July 1998 相似文献
77.
MOTIVATION: High-throughput 'ChIP-chip' and 'ChIP-seq' methodologies generate sufficiently large data sets that analysis poses significant informatics challenges, particularly for research groups with modest computational support. To address this challenge, we devised a software platform for storing, analyzing and visualizing high resolution genome-wide binding data. GeneTrack automates several steps of a typical data processing pipeline, including smoothing and peak detection, and facilitates dissemination of the results via the web. Our software is freely available via the Google Project Hosting environment at http://genetrack.googlecode.com 相似文献
78.
79.
Genomewide association study for susceptibility genes contributing to familial Parkinson disease 总被引:1,自引:0,他引:1
Pankratz N Wilk JB Latourelle JC DeStefano AL Halter C Pugh EW Doheny KF Gusella JF Nichols WC Foroud T Myers RH;PSG-PROGENI GenePD Investigators Coordinators Molecular Genetic Laboratories 《Human genetics》2009,124(6):593-605
Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD); however, mutations have been
found in fewer than 5% of patients, suggesting that additional genes contribute to disease risk. Unlike previous studies that
focused primarily on sporadic PD, we have performed the first genomewide association study (GWAS) in familial PD. Genotyping
was performed with the Illumina HumanCNV370Duo array in 857 familial PD cases and 867 controls. A logistic model was employed
to test for association under additive and recessive modes of inheritance after adjusting for gender and age. No result met
genomewide significance based on a conservative Bonferroni correction. The strongest association result was with SNPs in the
GAK/DGKQ region on chromosome 4 (additive model: p = 3.4 × 10−6; OR = 1.69). Consistent evidence of association was also observed to the chromosomal regions containing SNCA (additive model: p = 5.5 × 10−5; OR = 1.35) and MAPT (recessive model: p = 2.0 × 10−5; OR = 0.56). Both of these genes have been implicated previously in PD susceptibility; however, neither was identified in
previous GWAS studies of PD. Meta-analysis was performed using data from a previous case–control GWAS, and yielded improved
p values for several regions, including GAK/DGKQ (additive model: p = 2.5 × 10−7) and the MAPT region (recessive model: p = 9.8 × 10−6; additive model: p = 4.8 × 10−5). These data suggest the identification of new susceptibility alleles for PD in the GAK/DGKQ region, and also provide further support for the role of SNCA and MAPT in PD susceptibility.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
N. Pankratz and J. B. Wilk are joint first authors. 相似文献
80.