全文获取类型
收费全文 | 450篇 |
免费 | 52篇 |
出版年
2021年 | 5篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 15篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 14篇 |
2009年 | 12篇 |
2008年 | 21篇 |
2007年 | 10篇 |
2006年 | 13篇 |
2005年 | 16篇 |
2004年 | 13篇 |
2003年 | 17篇 |
2002年 | 11篇 |
2001年 | 18篇 |
2000年 | 14篇 |
1999年 | 8篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1995年 | 4篇 |
1994年 | 11篇 |
1993年 | 3篇 |
1992年 | 16篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1975年 | 10篇 |
1973年 | 7篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 5篇 |
1968年 | 5篇 |
1967年 | 10篇 |
1966年 | 5篇 |
1964年 | 5篇 |
1937年 | 3篇 |
排序方式: 共有502条查询结果,搜索用时 15 毫秒
51.
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila 总被引:1,自引:0,他引:1
Lee C Li X Hechmer A Eisen M Biggin MD Venters BJ Jiang C Li J Pugh BF Gilmour DS 《Molecular and cellular biology》2008,28(10):3290-3300
52.
In his considerations of “organs of extreme perfection,” Charles Darwin described the evidence that would be necessary to
support the evolutionary origin of the eye, namely, demonstration of the existence of “numerous gradations” from the most
primitive eye to the most perfect one, where each such tiny change had provided a survival advantage (however slight) to the
organism possessing the subtly altered form. In this paper, we discuss evidence indicating that the vertebrate eye did indeed
evolve through numerous subtle changes. The great majority of the gradual transitions that did occur have not been preserved
to the present time, either in the fossil record or in extant species; yet clear evidence of their occurrence remains. We
discuss the remarkable “eye” of the hagfish, which has features intermediate between a simple light detector and an image-forming
camera-like eye and which may represent a step in the evolution of our eye that can now be studied by modern methods. We also
describe the important clues to the evolutionary origin of the vertebrate eye that can be found by studying the embryological
development of our own eye, by examining the molecular genetic record preserved in our own genes and in the genes of other
vertebrates, and through consideration of the imperfections (or evolutionary “scars”) in the construction of our eye. Taking
these findings together, it is possible to discuss in some detail how the vertebrate eye evolved. 相似文献
53.
The sub-antarctic mite genus Neohyadesia (Acari: Astigmata) is known from two described taxa: N. signyi from Signy Island (South Orkney Islands, South Atlantic Province), and a subspecies, N. s. punctulata from Ile Kerguelen (South Indian Province). This paper describes a second species distinguishable by, in particular, cuticular
microtrichae covering the dorsal surface. The new species, N. microtricha sp. nov., has a similarly disjunct sub-antarctic distribution, occurring on both Marion (SIP) and South Georgia (SAP) islands.
A systematic synopsis of the sub-antarctic algophagine mites is given.
Accepted: 30 June 2000 相似文献
54.
Littoral Acari of Marion Island: ecology and extreme wave action 总被引:1,自引:1,他引:0
Fourteen species of littoral Acari (Arachnida) were collected from the shores of sub-Antarctic Marion Island, of which Parasitiphis brunneus (Kramer) (Ologamasidae), Rhombognathus apsteini Lohmann and R. gressitti Newell (Halacaridae) are new to the Prince Edward Islands. Acari, impoverished both in terms of diversity and abundance, were confined to the few micro-habitats, including rocky-shore lichens, kelp holdfasts, other macroalgae and the surface pitting of mobile boulders, which provided protection from the direct and indirect stresses of severe wave action. 相似文献
55.
Aphanizomenon flos-aquae (AFA) is a fresh-water microalgae that is consumed as a nutrient-dense food source and for its health-enhancing properties. The current research characterizes the effect of a water soluble preparation from AFA on human monocyte/macrophage function and compares the effect of AFA with responses from known agents that modulate the immune system. At 0.5 μg/ml the AFA extract robustly activated nuclear factor kappa B (NF-kappa B) directed luciferase expression in THP-1 human monocytic cells to levels at 50% of those achieved by maximal concentrations (10 μg/ml) of bacterial lipopolysaccharide (LPS). In addition, the AFA extract substantially increased mRNA levels of interleukin-1β(IL-1β) and tumor necrosis factor-(TNF-), and enhanced the DNA binding activity of NF-kappa B. The effects of AFA water soluble preparation were similar to the responses displayed by LPS, but clearly different from responses exhibited by tetradecanoyl phorbol acetate (TPA) and interferon-gamma (INF-γ). Pretreatment of THP-1 monocytes with factors known to induce hyporesponsiveness suppressed both AFA-dependent and LPS-dependent activation. These results suggest that the macrophage-activating properties of the AFA water soluble preparation are mediated through pathways that are similar to LPS-dependent activation. 相似文献
56.
57.
Multivariate analysis of surface water characteristics in the summer regime of the western Irish Sea
P. Foster G. Savidge G.M. Foster D.T.E. Hunt K.B. Pugh 《Journal of experimental marine biology and ecology》1976,25(2):171-185
A part of the western Irish Sea is strongly stratified during the summer months, with the boundary of stratification marked by a front with horizontal temperature gradients. Continuous on-line analysis has been used to record the surface water variability of nine characteristics along a cruise path in this area.Multivariate analysis (principal component) indicates the presence of four distinct water types separated by thermal gradients. Two of these water types show land mass influence and two illustrated the effects of the mixed and stratified regimes. The stratified surface waters had a marked degree of homogeneity with respect to the measured characteristics, while the mixed surface waters exhibited greater variability. Marked micro-variations in chlorophyll a concentrations were observed in the latter water type.No consistent relationships were observed among the physical, chemical, and biological variables across the front because of the gradual change in the gross properties of the mixed surface water during its northward passage through the Irish Sea. 相似文献
58.
Kung-Jong Lui Duane Steffey Jamie K. Pugh 《Biometrical journal. Biometrische Zeitschrift》1993,35(6):677-688
Calculating the required sample size for a desired power at a given type I error level, we often assume that we know the exact time of all subject responses whenever they occur during our study period. It is very common, however, in practice that we only monitor subjects periodically and, therefore, we know only whether responses occur or not during an interval. This paper includes a quantitative discussion of the effect resulting from data grouping or interval censoring on the required sample size when we have two treatment groups. Furthermore, with the goal of exploring the optimum in the number of subjects, the number of examinations per subject for test responses, and the total length of a study time period, this paper also provides a general guideline about how to determine these to minimize the total cost of a study for a desired power at a given α-level. A specified linear cost function that incorporates the costs of obtaining subjects, periodic examinations for test responses of subjects, and the total length of a study period, is assumed, primarily for illustrative purpose. 相似文献
59.
L. G. C. E. Pugh 《BMJ (Clinical research ed.)》1959,1(5116):192-196
60.