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711.
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Jane A. Lindborg Nicholas M. Tran Devon M. Chenette Kristin DeLuca Yram Foli Ramakrishnan Kannan Yuichi Sekine Xingxing Wang Marius Wollan In-Jung Kim Joshua R. Sanes Stephen M. Strittmatter 《Cell reports》2021,34(9):108777
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714.
715.
Kannan V. Manian Chad A. Galloway Sonal Dalvi Anthony A. Emanuel Jared A. Mereness Whitney Black Lauren Winschel Celia Soto Yiming Li Yuanhui Song William DeMaria Akhilesh Kumar Igor Slukvin Michael P. Schwartz William L. Murphy Bela Anand-Apte Mina Chung Danielle S.W. Benoit Ruchira Singh 《Cell Stem Cell》2021,28(5):846-862.e8
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716.
Varadharajan Vaishnavi Mayakannan Manikandan Arasambattu Kannan Munirajan 《基因组蛋白质组与生物信息学报(英文版)》2014,(2)
Autism spectrum disorder(ASD) refers to a group of childhood neurodevelopmental disorders with polygenic etiology. The expression of many genes implicated in ASD is tightly regulated by various factors including microRNAs(miRNAs), a class of noncoding RNAs 22 nucleotides in length that function to suppress translation by pairing with ‘miRNA recognition elements'(MREs) present in the 30untranslated region(30UTR) of target mRNAs. This emphasizes the role played by miRNAs in regulating neurogenesis, brain development and differentiation and hence any perturbations in this regulatory mechanism might affect these processes as well. Recently, single nucleotide polymorphisms(SNPs) present within 30UTRs of mRNAs have been shown to modulate existing MREs or even create new MREs. Therefore, we hypothesized that SNPs perturbing miRNA-mediated gene regulation might lead to aberrant expression of autism-implicated genes, thus resulting in disease predisposition or pathogenesis in at least a subpopulation of ASD individuals. We developed a systematic computational pipeline that integrates data from well-established databases. By following a stringent selection criterion, we identified 9 MRE-modulating SNPs and another 12 MRE-creating SNPs in the 30UTR of autism-implicated genes. These high-confidence candidate SNPs may play roles in ASD and hence would be valuable for further functional validation. 相似文献
717.
Arivalagan Pugazhendhi Sridevi Dhanarani Theivaraj Gowri Manogari Boovaragamoorthy Veerasamy Veeramani Kathirvel Brindhadevi Naif Abdullah Al-Dhabi Mariadhas Valan Arasu Thamaraiselvi Kaliannan 《Saudi Journal of Biological Sciences》2021,28(1):988
Tetracycline (TC) is one of the common antibiotics which is widely used in livestock growth promotion. The prevalent application TC may pave way to progression of antibiotic resistant bacteria. The main objective of this study is to determine the effect of Autothermal Thermophilic Aerobic Digestion (ATAD) on the fate of TC residues found in digested poultry litter. For the determination of TC in poultry litter, thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) were done. TLC result revealed that the Rf value of standard TC on TLC plate was 0.97 which correlates with the Rf value of TC at 0, 12, 24 and 36 h of digested poultry litter sample and not at 48, 60 and 72 h. HPLC chromatogram revealed that the limits of detection and the recovery were 5 µg/kg and 96% for standard TC. Linear correlation curves were obtained over the series of 100–500 µg/mL with correlation coefficient of 0.996 and the calibration curve was Y = 0.001X + 0.066. These results confirmed the degradation of TC in ATAD digestion of poultry litter by abiotic processes. 相似文献
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719.
K. Kannan G. Oblisami B. G. Loganathan 《World journal of microbiology & biotechnology》1990,6(4):404-407
A methanol-utilizing yeast,Candida boidinii, was isolated from cow dung. It could grow on a medium containing methanol or liquid paraffin as the only carbon source. Its cell yield after 7 days of growth on methanol was 0.34 g g–1 and on paraffin 0.30 g g–1. The organism was able to tolerate up to 4% (v/v) methanol.
This work was carried out while K. Kannan was at the Tamil Nadu Agricultural University. 相似文献
Résumé On a isolé une souche deCandida boidinii, levure utilisant le méthanol, à partir de bouse de vache. La souche était capable de croître sur un milieu contenant le méthanol ou la paraffine liquide, comme seule souche de carbone. Le rendement cellulaire après 7 jours de croissance était de 0.34 g par g de méthanol et 0.30 g par g de paraffine. L'organisme était capable de tolérer jusqu'à 4% (v/v) de méthanol.
This work was carried out while K. Kannan was at the Tamil Nadu Agricultural University. 相似文献
720.
A simple synthetic medium with glycine,l-tryptophan anddl-alanine was developed for study of antimycin A biogenesis. The strain produced 550 mg of mycelium dry weight and 200 μg of
antimycin A per 100 ml of this medium. Intense biosynthesis of antibiotic was initiated in early fermentation and optimum
yields were achieved after an additional 96 h incubation. No absolute relationship between growth rate and antimycin A production
intensity was found. Biogenesis of antimycin A via tryptophan and formylkynurenine is suggested and similarity in early biogenesis
of both antimycin A and actinomycin is considered. 相似文献