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41.
Effect of diabetes on the rhythm of [3H]thymidine incorporation in Con-A-stimulated mice splenocytes
The chronogram of hyperglycaemia in alloxan-induced diabetic DBA/2 mice (living under conditions standardized for light-synchronized periodicity and fed ad libitum) presented an ultradian rhythm (during spring) different from the circadian blood glucose chronogram of normal control mice. Simultaneously, the [3H]thymidine ([3H]TdR) incorporation chronogram of diabetic mouse splenocytes, stimulated or unstimulated with Concanavalin-A (Con-A), was changed and unbalanced, compared to that of normal control mice. Previous experiments showed that the [3H]TdR incorporation chronogram of stimulated or non-stimulated splenocytes of normal DBA/2 mice presented seasonal variations. They were characterized generally by an ultradian rhythm. Yet, during spring, they exhibited a circadian rhythm because one phase was advanced and superimposed on the other, the latter being typically unvarying. It seems probable that the unbalanced rhythm of [3H]TdR incorporated in diabetic mouse splenocytes, stimulated or not, was responsible for a dysfunction of that population in diabetes. 相似文献
42.
An ultradian rhythm of DNA synthesis and an in-vitro response to Concanavalin-A (Con-A) stimulation has been found in splenocytes of DBA/2 male mice, living under conditions standardized for light-synchronized periodicity. It was characterized by two peaks during the nycthemeral cycle. One of them was very sharp. In spite of a constant mode of synchronization of the animals, there were seasonal variations of the rhythm. Such variations did not, however, affect the position of the sharp peak, which occurred always at the same hour. The rhythm of incorporation of [3H]-thymidine by splenocytes, whether or not stimulated by Con-A, seemed correlated with that of blood insulin levels in mice. The possible effect of the physiological increase in blood insulin during the circadian cycle has been confirmed experimentally. Thus it seems probable that insulin would be one of the internal synchronizers . 相似文献
43.
An ultradian rhythm of DNA synthesis and an in-vitro response to Concanavalin-A (Con-A) stimulation has been found in splenocytes of DBA/2 male mice, living under conditions standardized for light-synchronized periodicity. It was characterized by two peaks during the nycthemeral cycle. One of them was very sharp. In spite of a constant mode of synchronization of the animals, there were seasonal variations of the rhythm. Such variations did not, however, affect the position of the sharp peak, which occurred always at the same hour. The rhythm of incorporation of [3H]-thymidine by splenocytes, whether or not stimulated by Con-A, seemed correlated with that of blood insulin levels in mice. the possible effect of the physiological increase in blood insulin during the circadian cycle has been confirmed experimentally. Thus it seems probable that insulin would be one of the internal synchronizers. 相似文献
44.
Sylvain Milla Xavier Terrien Armin Sturm Fidaa Ibrahim Franck Giton Jean Fiet Patrick Prunet Florence Le Gac 《Reproductive biology and endocrinology : RB&E》2008,6(1):19