全文获取类型
收费全文 | 1013篇 |
免费 | 47篇 |
国内免费 | 4篇 |
出版年
2024年 | 3篇 |
2023年 | 14篇 |
2022年 | 32篇 |
2021年 | 53篇 |
2020年 | 28篇 |
2019年 | 34篇 |
2018年 | 36篇 |
2017年 | 29篇 |
2016年 | 40篇 |
2015年 | 48篇 |
2014年 | 64篇 |
2013年 | 79篇 |
2012年 | 101篇 |
2011年 | 85篇 |
2010年 | 52篇 |
2009年 | 47篇 |
2008年 | 59篇 |
2007年 | 41篇 |
2006年 | 38篇 |
2005年 | 29篇 |
2004年 | 26篇 |
2003年 | 28篇 |
2002年 | 18篇 |
2001年 | 6篇 |
2000年 | 7篇 |
1999年 | 7篇 |
1998年 | 5篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1974年 | 5篇 |
1968年 | 1篇 |
排序方式: 共有1064条查询结果,搜索用时 31 毫秒
991.
Keshaav Krishnaa Pothapur Veeraraghavan Vishnu Priya Gayathri Rengasamy Vijayashree Priyadharsini Jayaseelan 《Bioinformation》2020,16(11):837
Periodontitis is attributed to the dental biofilm formation. Red complex organisms are a group of organisms linked with periodontal diseases. Therefore, it is of interest to identify potential targets from the red complex organisms to bind with the herbal compound resveratrol (E - 5 - (4 - hydroxy styryl) benzene 1,3 diol). We report a list of potential proteins having optimal drug like binding features with the herbal agent Resveratrol for further consideration. We used the STITCH v.5 pipeline VICMPred and VirulentPred tools to identify such targets as potential virulent factors in the red complex organisms. We considered the strains of Porphyromonas gingivalis ATCC 33277, Treponema denticola ATCC 35405 and Tannerella forsythia ATCC 43037 in the red complex pathogens for this analysis. Protein targets in the red complex organisms with optimal binding features with the herbal compound resveratrol were thus identified and reported for further consideration. 相似文献
992.
Jyothi K. Rajashekar Jonathan Richard Jagadish Beloor Jérémie Prévost Sai Priya Anand Guillaume Beaudoin-Bussières Liang Shan Dietmar Herndler-Brandstetter Gabrielle Gendron-Lepage Halima Medjahed Catherine Bourassa Fleur Gaudette Irfan Ullah Kelly Symmes Andrew Peric Emily Lindemuth Frederic Bibollet-Ruche Jun Park Priti Kumar 《Cell host & microbe》2021,29(6):904-916.e6
993.
994.
Faisal Bin Rahman Sium Ahmed Priya Noor Mir Md. Mahbubur Rahman S.M. Azimul Huq Md. Taharat Elahi Akib Abdullah Mohammad Shohael 《Biochemistry and Biophysics Reports》2020
Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. are three ornamental plants that produce colorful flowers. The present study aimed to evaluate the phytochemicals and bioactivities of methanolic extracts of flowers from Delonix regia (DrFME), Cassia fistula (CfFME), and Lagerstroemia speciosa (LsFME). The presence of ten different chemical classes in varying degrees was confirmed while qualitatively screened. During quantitative determination, LsFME possesses the highest amount of total phenolic (418.0 mg/g), flavonoid (50.8 mg/g), and tannin (256.3 mg/g) contents. The extracts showed excellent antioxidant capacity in a concentration-dependent manner with the lowest IC50 value (41.51 μg/mL) displayed by LsFME. LsFME paralyzed the experimental worms at 2.95 min and killed at 3.96 min. DrFME was found to be more effective in thrombolytic (35.5% clot lysis) and anticoagulant activities. Negligible hemolytic activity (IC50 > 200 μg/mL) found for all extracts which suggest their less potential toxicity. The in vivo experiments revealed that the CfFME has the highest analgesic (64.34% pain inhibition) activity while LsFME has the highest antidiarrheal (70.27% inhibition) and antihyperglycemic (46.94% inhibition) activities at 400 mg/kg of body weight doses. This study has shown the presence of phytochemicals and potential bioactivities which indicates the possibility of these flowers to be used as a source of phytochemicals as well as safe and effective natural medicine. 相似文献
995.
Mukesh Kumar Kanwar Poonam Sikander Pal 《International journal of phytoremediation》2015,17(12):1237-1243
Brassica juncea (Indian mustard) L. plants were exposed to different concentrations (0.0, 0.1, 0.3 and 0.5 mM) of Chromium (Cr) and harvested after 30 and 60 days of sowing for the analysis of growth parameters, metal uptake and oxidative stress markers. Significant accumulation of Cr (VI) by B. juncea L. plants resulted in the reduced growth and modulations in the pool of various biochemical stress markers. The toxic effects of Cr (VI) on growth and other stress markers (protein content, lipid peroxidation and antioxidative enzymes viz.SOD, CAT, POD, APOX, GR, DHAR and MDHAR) in B. juncea L. were observed to be concentration and time dependent. Effect of Cr (VI) on biochemical parameters was differential and their maximum activities of SOD, POD, APX, GR, DHAR and lipid peroxidation were recorded at 0.5 mM concentration in 30 days old plants. Whereas, trend in the activities of most of the stress markers was reversed in 60 days old plants. The results obtained from the study suggested that Cr (VI) stress inhibited growth of B. juncea L. plants is directly interrelated with its accumulation and resulted in the modulation in activities of various stress markers. 相似文献
996.
997.
998.
Meike G?lzenleuchter Rahul Kanwar Manal Zaibak Fadi Al Saiegh Theresa Hartung Jana Klukas Regenia L Smalley Julie M Cunningham Maria E Figueroa Gary P Schroth Terry M Therneau Michaela S Banck Andreas S Beutler 《Epigenetics》2015,10(3):200-212
The response of the peripheral nervous system (PNS) to injury may go together with alterations in epigenetics, a conjecture that has not been subjected to a comprehensive, genome-wide test. Using reduced representation bisulfite sequencing, we report widespread remodeling of DNA methylation in the rat dorsal root ganglion (DRG) occurring within 24 h of peripheral nerve ligation, a neuropathy model of allodynia. Significant (P < 10−4) cytosine hyper- and hypo-methylation was found at thousands of CpG sites. Remodeling occurred outside of CpG islands. Changes affected genes with known roles in the PNS, yet methylome remodeling also involved genes that were not linked to neuroplasticity by prior evidence. Consistent with emerging models relying on genome-wide methylation and RNA-seq analysis of promoter regions and gene bodies, variation of methylation was not tightly linked with variation of gene expression. Furthermore, approximately 44% of the dynamically changed CpGs were located outside of genes. We compared their positions with the intergenic, tissue-specific differentially methylated CpGs (tDMCs) of an independent experimental set consisting of liver, spleen, L4 control DRG, and muscle. Dynamic changes affected those intergenic CpGs that were different between tissues (P < 10−15) and almost never the invariant portion of the methylome (those CpGs that were identical across all tissues). Our findings—obtained in mixed tissue—show that peripheral nerve injury leads to methylome remodeling in the DRG. Future studies may address which of the cell types found in the DRG, such as specific groups of neurons or non-neuronal cells are affected by which aspect of the observed methylome remodeling. 相似文献
999.
Alexandra Tauzin Manon Nayrac Mehdi Benlarbi Shang Yu Gong Romain Gasser Guillaume Beaudoin-Bussières Nathalie Brassard Annemarie Laumaea Dani Vézina Jérémie Prévost Sai Priya Anand Catherine Bourassa Gabrielle Gendron-Lepage Halima Medjahed Guillaume Goyette Julia Niessl Olivier Tastet Laurie Gokool Andrés Finzi 《Cell host & microbe》2021,29(7):1137-1150.e6
1000.
Priya Verma 《Carbohydrate research》2009,344(18):2554-1388
Convergent synthesis of two trisaccharides related to the cytotoxic triterpenoid saponin isolated from Pithecellobium lucidum is reported. The trisaccharides are synthesized in the form of their propargyl glycosides to leave the scope for further glycoconjugate formation through various multi-component reactions. A simple protecting group manipulation is followed using commercially available monosaccharides, d-glucose, d-xylose, d-fucose and l-rhamnose. H2SO4 immobilized on silica is used as the Brönsted acid source for the N-iodosuccinimide-mediated thioglycoside activation for stereoselective glycosylations and proved to be a better choice over traditional Lewis acid catalysts such as TMSOTf and TfOH. 相似文献