全文获取类型
收费全文 | 373篇 |
免费 | 40篇 |
出版年
2023年 | 5篇 |
2021年 | 3篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2017年 | 8篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 14篇 |
2013年 | 14篇 |
2012年 | 20篇 |
2011年 | 15篇 |
2010年 | 13篇 |
2009年 | 4篇 |
2008年 | 18篇 |
2007年 | 16篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 12篇 |
2003年 | 7篇 |
2002年 | 7篇 |
2001年 | 15篇 |
2000年 | 10篇 |
1999年 | 13篇 |
1998年 | 12篇 |
1997年 | 3篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1993年 | 6篇 |
1992年 | 7篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 7篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1975年 | 4篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1970年 | 3篇 |
1942年 | 2篇 |
1931年 | 2篇 |
排序方式: 共有413条查询结果,搜索用时 15 毫秒
51.
Background
Iron supplementation is employed to treat post-malarial anaemia in environments where iron deficiency is common. Malaria induces an intense inflammatory reaction that stalls reticulo-endothelial macrophagal iron recycling from haemolysed red blood cells and inhibits oral iron absorption, but the magnitude and duration of these effects are unclear.Methodology/Principal Findings
We examined the red blood cell incorporation of oral administered stable isotopes of iron and compared incorporation between age matched 18 to 36 months old children with either anaemia post-malaria (n = 37) or presumed iron deficiency anaemia alone (n = 36). All children were supplemented for 30 days with 2 mg/kg elemental iron as liquid iron sulphate and administered 57Fe and 58Fe on days 1 and 15 of supplementation respectively. 57Fe and58Fe incorporation were significantly reduced (8% vs. 28%: p<0.001 and 14% vs. 26%: p = 0.045) in the malaria vs. non-malaria groups. There was a significantly greater haemoglobin response in the malaria group at both day 15 (p = 0.001) and 30 (p<0.000) with a regression analysis estimated greater change in haemoglobin of 7.2 g/l (s.e. 2.0) and 10.1 g/l (s.e. 2.5) respectively.Conclusion/Significance
Post-malaria anaemia is associated with a better haemoglobin recovery despite a significant depressant effect on oral iron incorporation which may indicate that early erythropoetic iron need is met by iron recycling rather than oral iron. Supplemental iron administration is of questionable utility within 2 weeks of clinical malaria in children with mild or moderate anaemia. 相似文献52.
Parsons JB Dinesh SD Deery E Leech HK Brindley AA Heldt D Frank S Smales CM Lünsdorf H Rambach A Gass MH Bleloch A McClean KJ Munro AW Rigby SE Warren MJ Prentice MB 《The Journal of biological chemistry》2008,283(21):14366-14375
Many heterotrophic bacteria have the ability to make polyhedral structures containing metabolic enzymes that are bounded by a unilamellar protein shell (metabolosomes or enterosomes). These bacterial organelles contain enzymes associated with a specific metabolic process (e.g. 1,2-propanediol or ethanolamine utilization). We show that the 21 gene regulon specifying the pdu organelle and propanediol utilization enzymes from Citrobacter freundii is fully functional when cloned in Escherichia coli, both producing metabolosomes and allowing propanediol utilization. Genetic manipulation of the level of specific shell proteins resulted in the formation of aberrantly shaped metabolosomes, providing evidence for their involvement as delimiting entities in the organelle. This is the first demonstration of complete recombinant metabolosome activity transferred in a single step and supports phylogenetic evidence that the pdu genes are readily horizontally transmissible. One of the predicted shell proteins (PduT) was found to have a novel Fe-S center formed between four protein subunits. The recombinant model will facilitate future experiments establishing the structure and assembly of these multiprotein assemblages and their fate when the specific metabolic function is no longer required. 相似文献
53.
54.
55.
56.
Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented. 相似文献
57.
58.
59.
60.