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41.
Summary Ion fluxes after ethanol addition to Candida utilis depend crucially on aeration (air versus oxygen). In O2-aerated non-growing cells ethanol causes an H + / K + exchange and an extrusion of acetate and lactate accompanied mostly by K +, and their subsequent reimportation together with H +. Cells from continuous culture display generally stronger acidification and more marked K + movements than non-growing ones.
Offprint requests to: A. Prell 相似文献
42.
Summary Phage P22 defective in gene 24 and harbouring the oc mutation k5 in OR exhibits a strongly increased c2-repressor synthesis after infection of non-lysogenic S. typhimurium. The repressor synthesis depends strictly on an intact c1 gene. The kinetics of its synthesis, as monitored by polyacrylamid gel electrophoresis, is the same as with P22 c
+, namely a turn off 8–10 min after infection. — After infection of P22-lysogenic bacteria with either P22 24
–
k5 or P22 24
–
k5 cl, much lower amounts of repressor are synthesized but again with the same kinetics. These results suggest a cro-like function acting at PRE and PRM of P22. The possible reason for the c2 overproduction is discussed. 相似文献
43.
In oxygen-aerated non-growing cells a subinhibitory ethanol concentration (1 g/L) causes an H+/K+ exchange. An inhibitory ethanol concentration (30 g/L) slows down acidification but has no effect on its extent. The transmembrane
ΔpH depends directly on the ethanol level in the medium and is not lowered at high ethanol concentrations. Changes in membrane
potential induced by ethanol are also concentration dependent. The high ethanol level does not increase the passive permeability
of cell membrane to H+. 相似文献
44.
Summary Phage mutants were isolated with amber mutations in genes necessary for establishment of lysogeny. These mutants form turbid plaques on su
+ strain 527R1 and clear plaques of different types on LT2. According to complementation tests, fourteen mutants fall in the c
2 gene, four in the c
3 gene but no amber mutants were found belonging to the c
1 gene. Pulse labelling experiments to follow DNA synthesis after phage infection were done with the mutants classified by complementation tests. Furthermore the labelling experiments demonstrated that the nonleaky c
3 amber mutants displayed the same DNA synthesis pattern as c
1 missense mutants. Since these c
3 amber mutants complement missense c
1 mutants it is concluded that the c
3 and c
1 genes must act together for the first transient repression of DNA synthesis, i.e., seven minutes after infection. It is suggested that clear plaque forming c
1 amber mutants cannot be isolated because of polarity leading to defectivity of lysogenic as well as of lytic functions.The majority of the experiments presented are a part of the dissertation of H. D. Dopatka at the University of Göttingen. 相似文献
45.
Burgeff F. Alverdes Küster Roux H. Stieve W. Kornfeld H. Prell Wetzel Dr. G. Ettisch A. Pratje B. Klatt 《Development genes and evolution》1922,50(3-4):618-644
Ohne Zusammenfassung 相似文献
46.
47.
Heinrich Prell 《Development genes and evolution》1922,51(1):1-23
Ohne Zusammenfassung
Mit 5 Textabbildunge. 相似文献
48.
Background
As the origin of a life-and-death signal detected from systemic arterial pressure, which sequentially increases (pro-life) and decreases (pro-death) to reflect progressive dysfunction of central cardiovascular regulation during the advancement towards brain stem death in critically ill patients, the rostral ventrolateral medulla (RVLM) is a suitable neural substrate for mechanistic delineation of this fatal phenomenon. The present study assessed the hypothesis that extracellular signal-regulated kinase 1/2 (ERK1/2), a member of the mitogen-activated protein kinases (MAPKs) that is important for cell survival and is activated specifically by MAPK kinase 1/2 (MEK1/2), plays a pro-life role in RVLM during brain stem death. We further delineated the participation of MAPK signal-interacting kinase (MNK), a novel substrate of ERK in this process. 相似文献49.
A method was developed to demonstrate recA-dependent P22-repressor breakdown in vivo by SDS-polyacrylamide electrophoresis of unfractionated extracts of phage-infected, lysogenic Salmonella typhimurium strains TA1530 rec+ and TA1530 recA1-. The antirepressor of P22 is not cleaved by recA protein. Under conditions of unregulated ant-overproduction (Harvey et al. 1981) antirepressor protects c2-repressor in vivo against proteolytic cleavage by recA protein. 相似文献
50.
† Patrizio Blandina Giovanna Cherici Flavio Moroni †George D. Prell †Jack Peter Green 《Journal of neurochemistry》1995,64(2):788-793
Abstract: The effect of pros -methylimidazoleacetic acid (p-MIAA) was measured on the release of glutamate and aspartate from cerebral cortex, hippocampus, and striatum of freely moving rats, and on the uptake of 14 C by striatal slices incubated in the presence of l -[14 C]-glutamate. Twenty-four hours after implantation of a dialysis fiber, striatum, hippocampus, or cerebral cortex spontaneously released both glutamate and aspartate in the micromolar range. p-MIAA (1 µ M to 1 m M ), added to the dialysis perfusate, elicited a concentration-dependent increase of glutamate release from striatum with a maximal increase of about threefold. This effect did not occur in hippocampus or cortex. In none of these regions did p-MIAA increase aspartate release significantly. The p-MIAA effect was not mimicked by its isomer tele -methylimidazoleacetic acid. p-MIAA did not influence the uptake of glutamate by striatal slices. The glutamate-releasing action of p-MIAA may affect striatal function and explain the positive correlation between levels of p-MIAA in CSF and the severity of Parkinson's disease. 相似文献