排序方式: 共有465条查询结果,搜索用时 54 毫秒
451.
452.
Shweta V. Pawar 《Preparative biochemistry & biotechnology》2020,50(6):627-634
AbstractBiological molecules are widely produced by fermentation technology using bacteria, fungi or yeast. Fermentation is a biochemical process wherein the rate of bioconversion is governed by the organisms involved. The growth of the organism is mainly limited by mass transfer rates of nutrients and gases that directly affect the product formation in fermentation. Attempts have been made to enhance the growth rate and yield using mutational, recombinant strain development approach at microbial level as well as fed batch and continuous processing approach at bioprocess level in the past. The growth rate of microbes can be accelerated by increased mass transfer rates and cell wall permeability with the use of controlled low frequency ultrasound irradiation. The present review provides insights into the application of acoustic cavitation in process intensification of fermentation approaches and the role of various factors involved are highlighted with typical examples. 相似文献
453.
454.
455.
Yimeng Wang Katie A. Howell Jennifer Brannan Krystle N. Agans Hannah L. Turner Ariel S. Wirchnianski Shweta Kailasan Marnie Fusco Andrey Galkin Chi-I Chiang Xuelian Zhao Erica Ollmann Saphire Kartik Chandran Andrew B. Ward John M. Dye M. Javad Aman Thomas W. Geisbert Yuxing Li 《Journal of virology》2021,95(8)
456.
457.
Manape Tushar Kashinath Satheesh Viswanathan Singh Shweta Singh Major Anandhan Sivalingam 《Plant Cell, Tissue and Organ Culture》2022,148(1):61-72
Plant Cell, Tissue and Organ Culture (PCTOC) - A high-auxin medium, usually used for callus induction, was not effective for Indian short-day onion cv. Bhima super. In this study, we found that the... 相似文献
458.
Shweta Mittar Gareth J. Howell Ian Zachary Sreenivasan Ponnambalam 《Experimental cell research》2009,315(5):877-2681
Vascular endothelial growth factor receptor 1 (VEGFR1) is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis but its function is not well understood. Herein, we present evidence whereby endothelial VEGFR1 is largely resident within the Golgi apparatus but translocates to the plasma membrane via a calcium-regulated process. Primary human endothelial cells reveal differing VEGFR1 and VEGFR2 intracellular distribution and dynamics. The major proportion of the full-length VEGFR1 membrane protein was resident within the Golgi apparatus in primary endothelial cells. Whereas VEGFR2 displayed down-regulation in response to VEGF-A, VEGFR1 was not significantly affected arguing for a significant intracellular pool that was inaccessible to extracellular VEGF-A. This intracellular VEGFR1 pool showed significant co-distribution with key Golgi residents. Brefeldin A caused VEGFR1 Golgi fragmentation consistent with redistribution to the endoplasmic reticulum. Metabolic labeling experiments and microscopy using domain-specific VEGFR1 antibodies indicated that the mature processed VEGFR1 species and an integral membrane protein was resident within Golgi apparatus. Cytosolic calcium ions play a key role in VEGFR1 trafficking as treatment with either VEGF-A, histamine, thrombin, thapsigargin or A23187 ionophore caused VEGFR1 redistribution from the Golgi apparatus to small punctate vesicles and plasma membrane. We thus propose a model whereby the balance of VEGFR1 and VEGFR2 plasma membrane levels dictate either negative or positive endothelial signaling to influence vascular physiology. 相似文献
459.
460.