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81.
Kumar R Ramachandran U Khanna S Bharatam PV Raichur S Chakrabarti R 《Bioorganic & medicinal chemistry》2007,15(3):1547-1555
A novel series of l-tyrosine derivatives have been reported with potential PPARalpha/gamma dual agonistic activity. In vitro cell based PPARalpha/gamma transactivation studies have shown compound 4a and compound 4f to be the most potent PPARgamma and PPARalpha activators, respectively. Molecular docking studies performed on these series of compounds have complemented the experimental results and have led to interesting inferences. 相似文献
82.
Biotechnological conversion of agro-industrial wastewaters into biodegradable plastic, poly beta-hydroxybutyrate 总被引:1,自引:0,他引:1
Khardenavis AA Suresh Kumar M Mudliar SN Chakrabarti T 《Bioresource technology》2007,98(18):3579-3584
Waste activated sludge generated from a combined dairy and food processing industry wastewater treatment plant was evaluated for its potential to produce biodegradable plastic, poly beta-hydroxybutyric acid (PHB). Deproteinized jowar grain-based distillery spentwash yielded 42.3% PHB production (w/w), followed by filtered rice grain-based distillery spentwash (40% PHB) when used as substrates. Addition of di-ammonium hydrogen phosphate (DAHP) resulted in an increase in PHB production to 67% when raw rice grain-based spentwash was used. Same wastewater, after removal of suspended solids by filtration and with DAHP supplementation resulted in lower PHB production (57.9%). However, supplementing other wastes with DAHP led to a substantial decrease in PHB content in comparison to what was observed in the absence of DAHP. 相似文献
83.
MOTIVATION: The increasing amount of data on protein-protein interaction needs to be rationalized for deriving guidelines for the alteration or design of an interface between two proteins. RESULTS: We present a detaild structural analysis and comparison of homo- versus heterodimeric protein-protein interfaces. Regular secondary structures (helices and strands) are the main components of the former, whereas non-regular structures (turns, loops, etc.) frequently mediate interactions in the latter. Interface helices get longer with increasing interface area, but only in heterocomplexes. On average, the homodimers have longer helical segments and prominent helix-helix pairs. There is a surprising distinction in the relative orientation of interface helices, with a tendency for aligned packing in homodimers and a clear preference for packing at 90 degrees in heterodimers. Arg and the aromatic residues have a higher preference to occur in all secondary structural elements (SSEs) in the interface. Based on the dominant SSE, the interfaces have been grouped into four classes: alpha, beta, alphabeta and non-regular. Identity between protein and interface classes is the maximum for alpha proteins, but rather mediocre for the other protein classes. The interface classes of the two chains forming a heterodimer are often dissimilar. Eleven binding motifs can capture the prominent architectural features of most of the interfaces. 相似文献
84.
Banani Bindhani Sulagna Maity Ipsit Chakrabarti Samir Kumar Saha 《Archives of insect biochemistry and physiology》2022,109(1):e21849
Matrix metalloproteinase (MMP), a protease enzyme, participates in proteolytic cleavage of extracellular matrix proteins from Drosophila and mammals. But, recent studies have revealed other physiologically important roles of MMP in Drosophila. MMP contributes to cardioblast movement and distribution of collagen proteins during cardiogenesis in developing Drosophila. Tissue remodeling, especially tracheal development is also maintained by MMP. MMP regulates certain immunological functions in Drosophila such as wound repairing, plasmatocyte assemblage at the injured site of the basement membrane and glial response to axon degeneration in Drosophila nervous system. But, the contribution of MMP to tumor formation and metastasis in Drosophila has made it an interesting topic among researchers. Ovulation and egg laying are also found to be affected positively by MMP in Drosophila. 相似文献
85.
Pruthi Himanshu Muthu Valliappan Bhujade Harish Sharma Arun Baloji Abhiman Ratnakara Rao G Bal Amanjit Singh Harkant Sandhu Manavjit Singh Negi Sunder Chakrabarti Arunaloke Singhal Manphool 《Mycopathologia》2022,187(1):31-37
Mycopathologia - Literature on COVID-19-associated pulmonary mucormycosis (CAPM) is sparse. Pulmonary artery pseudoaneurysm (PAP) is an uncommon complication of pulmonary mucormycosis (PM), and... 相似文献
86.
Muthu Valliappan Dhaliwal Manpreet Sharma Arunima Nair Divya Kumar H. Mohan Rudramurthy Shivaprakash M. Sehgal Inderpaul Singh Choudhary Hansraj Panda Naresh Chakrabarti Arunaloke Agarwal Ritesh 《Mycopathologia》2022,187(4):355-362
Mycopathologia - In experimental models, the expression of glucose-regulated protein 78 (GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However, the role of GRP78 in... 相似文献
87.
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89.
A pentachlorophenol (PCP) degrading bacterium was isolated and characterized from sludge of pulp and paper mill. This isolate
used PCP as its sole source of carbon and energy and was capable of degrading this compound, as indicated by stoichiometric
release of chloride and biomass formation. Based on morphology, biochemical tests, and 16S rRNA gene sequence analysis this
strain was identified as Kocuria sp. CL2. High Performance Liquid Chromatography (HPLC) analysis revealed that this strain was able to degrade PCP up to a
concentration of 600 mg/l. This is first time we are reporting the degradation of PCP by the Kocuria species. This isolate was also able to remove 58.64% of PCP from the sludge within two weeks. This study showed that the
removal efficiency of PCP by CL2 was found to be very effective and can be used in degradation of PCP containing pulp paper
mill waste in the environment. 相似文献
90.
Subhrojit SenShali Chen Biao FengYuexiu Wu Edmund LuiSubrata Chakrabarti 《Phytomedicine》2011,18(13):1110-1117