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71.
72.
K. V. N. Rao D. A. Mitchison N. G. K. Nair K. Prema S. P. Tripathy 《BMJ (Clinical research ed.)》1970,3(5721):495-497
Sulphadimidine acetylation studies were undertaken in 103 patients, 52 of whom had been classified as slow and 51 as rapid inactivators of isoniazid by a standard microbiological assay method. Each patient received sulphadimidine by mouth in a dose of 44 mg./kg. body weight, and free and total sulphadimidine were estimated in blood and urine collected at six hours. The findings suggest that patients may be classified as slow inactivators of isoniazid if the proportion of acetylated sulphadimidine (total minus free) is (a) less than 25% in blood or (b) less than 70% in urine. The sulphadimidine test is easy to perform and the result is available the same day; urine specimens for the test can be stored at room temperature for over a week without any loss of drug. 相似文献
73.
Donald B. Jump Christopher M. Depner Sasmita Tripathy 《Journal of lipid research》2012,53(12):2525-2545
Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C20–22 ω 3 polyunsaturated fatty acids (PUFA)], blood levels of C20–22 ω 3 PUFA, and mortality associated with cardiovascular disease (CVD). C20–22 ω 3 PUFA have pleiotropic effects on cell function and regulate multiple pathways controlling blood lipids, inflammatory factors, and cellular events in cardiomyocytes and vascular endothelial cells. The hypolipemic, anti-inflammatory, anti-arrhythmic properties of these fatty acids confer cardioprotection. Accordingly, national heart associations and government agencies have recommended increased consumption of fatty fish or ω 3 PUFA supplements to prevent CVD. In addition to fatty fish, sources of ω 3 PUFA are available from plants, algae, and yeast. A key question examined in this review is whether nonfish sources of ω 3 PUFA are as effective as fatty fish-derived C20–22 ω 3 PUFA at managing risk factors linked to CVD. We focused on ω 3 PUFA metabolism and the capacity of ω 3 PUFA supplements to regulate key cellular events linked to CVD. The outcome of our analysis reveals that nonfish sources of ω 3 PUFA vary in their capacity to regulate blood levels of C20–22 ω 3 PUFA and CVD risk factors. 相似文献
74.
Ganguly A Chakraborty P Banerjee K Chatterjee S Basu S Sarkar A Chatterjee M Choudhuri SK 《Biometals》2012,25(1):149-163
Multidrug resistance-associated protein 1 (MRP1) reduces intracellular anticancer drug accumulation either by co transporting
them with glutathione (GSH) or extruding drug-GSH conjugates outside of the cell. Thus, MRP1 confers multidrug resistance
(MDR) and worsen successful chemotherapeutic treatment against cancer. Although the exact mechanism of MRP1 involved in MDR
remains unknown, the elevated level of intracellular GSH is considered as a key factor responsible for MDR in cancer. Hence
the quest for non-toxic molecules that are able to deplete intracellular GSH has profound importance to subdue MDR. The present
preclinical study depicts the resistance reversal potentiality of an iron complex; viz. Ferrous N-(2-hydroxy acetophenone) glycinate (FeNG) developed by us in doxorubicin resistant Ehrlich ascites carcinoma (EAC/Dox) cells.
FeNG potentiate cytotoxic effect of doxorubicin on EAC/Dox cells ex vivo and also increases the survivability EAC/Dox bearing
Swiss albino mice in vivo as well. Moreover, in vivo administration of FeNG significantly depletes intracellular GSH with
ensuant increase in doxorubicin concentration in EAC/Dox cells without alternation of MRP1 expression. In addition, intra-peritoneal
(i.p.) application of FeNG in normal or EAC/Dox bearing mice does not cause any systemic toxicity in preliminary trials in
mouse Ehrlich ascites carcinoma model. Therefore, the present report provides evidence that FeNG may be a promising new resistance
modifying agent against drug resistant cancers. 相似文献
75.
Tripathy S Berger EJ 《Computer methods in biomechanics and biomedical engineering》2012,15(5):475-486
Costal cartilage (CC) is one of the load-bearing tissues of the rib cage. Literature on material characterisation of the CC is limited. Atomic force microscopy (AFM) has been extremely successful in characterising the elastic properties of soft biomaterials such as articular cartilage and hydrogels, which are often the material of choice for cartilage models. But AFM data on CC are absent in the literature. In this study, AFM indentations using spherical beaded tips were performed on human CC to isolate the mechanical properties. A novel method was developed for modelling the relaxation indentation experiments based on Fung's quasi-linear viscoelasticity and a continuous relaxation spectrum. This particular model has been popular for uniaxial compression test data analysis. Using the model, the mean Young's modulus of CC was found to be about 2.17, 4.11 and 5.49?MPa for three specimens. A large variation of modulus was observed over the tissue. Also, the modulus values decreased with distance from the costochondral junction. 相似文献
76.
77.
Tripathy R Reiboldt A Messina PA Iqbal M Singh J Bacon ER Angeles TS Yang SX Albom MS Robinson C Chang H Ruggeri BA Mallamo JP 《Bioorganic & medicinal chemistry letters》2006,16(8):2158-2162
Structural analysis of the essential binding elements of the oxindole-based kinase inhibitor (1) led to the identification of a novel class of heterocyclic-substituted pyrazolones. Knoevenagel condensation of a variety of activated methylene nucleophiles with indole or pyrrole carboxaldehydes provided a focused library of molecules, each containing elements of kinase pharmacophore probe. Initial screening for VEGFR-2 kinase inhibition eliminated several of the probes. Identification of an active pyrazolone motif and further optimization resulted in several highly potent VEGFR-2 inhibitors with cellular efficacy, anti-angiogenic activity ex vivo in rat aortic ring explant cultures, and oral anti-tumor efficacy in nude mice. 相似文献
78.
Focus on antivirally active sulfated polysaccharides: from structure-activity analysis to clinical evaluation 总被引:4,自引:0,他引:4
In recent years, many compounds having potent antiviral activityin cell culture have been detected and some of these compoundsare currently undergoing either preclinical or clinical evaluation.Among these antiviral substances, naturally occurring sulfatedpolysaccharides and those from synthetic origin are noteworthy.Recently, several controversies over the molecular structuresof sulfated polysaccharides, viral glycoproteins, and cell-surfacereceptors have been resolved, and many aspects of their antiviralactivity have been elucidated. It has become clear that theantiviral properties of sulfated polysaccharides are not onlya simple function of their charge density and chain length butalso their detailed structural features. The in vivo efficacyof these compounds mostly corresponds to their ability to inhibitthe attachment of the virion to the host cell surface althoughin some cases virucidal activity plays an additional role. Thisreview summarizes experimental evidence indicating that sulfatedpolysaccharides might become increasingly important in drugdevelopment for the prevention of sexually transmitted diseasesin the near future. 相似文献
79.
The present paper reports the graft copolymerization of N-vinylformamide onto sodium carboxymethylcellulose by free radical polymerization using potassium peroxymonosulphate/thiourea redox system in an inert atmosphere. The reaction conditions for maximum grafting have been optimized by varying the reaction variables, including the concentration of N-vinylformamide (12.0 × 10−2–28.0 × 10−2 mol dm−3), potassium peroxymonosulphate (4.0 × 10−3–12.0 × 10−3 mol dm−3), thiourea (1.2 × 10−3–4.4 × 10−3 mol dm−3), sulphuric acid (2.0 × 10−3–10.0 × 10−3 mol dm−3), sodium carboxymethylcellulose (0.2–1.8 g dm−3) along with time duration (60–180 min) and temperature (25–45° C). Water swelling capacity, metal ion sorption and flocculation studies of synthesized graft copolymer have been performed with respect to the parent polymer. The graft copolymer has been characterized by FTIR spectroscopy and thermogravimetric analysis. 相似文献
80.
Mahapatra P Kumari A Garlapati VK Banerjee R Nag A 《Indian journal of microbiology》2010,50(4):396-403
Extracellular lipase was produced from Rhizopus oligosporus NRRL 5905 through solid state fermentation (SSF). To provide an optimum fermentation conditions for maximum lipase yield,
five process variables (temperature, liquid–solid ratio, pH, incubation period and spore concentration) were optimized using
evolutionary operation (EVOP) factorial design technique taking into account the interaction between the process variables.
Optimization through EVOP resulted in around 3 fold increase in lipase activity (77 U gds−1) at a liquid–solid ratio of 1.5:1, fermentation temperature of 35°C, initial fermentation pH 6, incubation period 5 days
and a spore concentration of 108 spores ml−1. 相似文献