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61.
Clément Lagrue Robert Poulin Devon B. Keeney 《Evolution; international journal of organic evolution》2009,63(6):1417-1426
Theoretical models predict that genetic relatedness affects the competition within and between parasite clonal groups sharing a common host. Here, we studied natural and experimental multiple infections of the trematode Coitocaecum parvum in its intermediate host. We focused on the effects of clonality on the life-history strategy of parasites competing for resources. Coitocaecum parvum can either delay maturation until its amphipod host is ingested by a definitive host, or adopt a progenetic strategy and reproduce inside the amphipod. Within a common host, clonal parasites were more likely to adopt identical life-history strategies than different genetic clones, both in natural and experimental infections. However, when timing of infection and other factors were controlled experimentally, parasites sharing a host were likely to adopt identical strategies regardless of their clonal identity, although pairs of clones were more likely to adopt progenesis than pairs of nonclones. The asymmetries in relative size and egg production between coinfecting parasites adopting the same life-history strategy were slightly, but not significantly, higher between different clones than identical clones. Our results suggest that the dynamics of competition between coinfecting parasites, although influenced by numerous external factors, is also modulated by genetic relatedness among parasites. 相似文献
62.
Poulin R 《Proceedings. Biological sciences / The Royal Society》2000,267(1445):787-792
New scientific paradigms often generate an early wave of enthusiasm among researchers and a barrage of studies seeking to validate or refute the newly proposed idea. All else being equal, the strength and direction of the empirical evidence being published should not change over time, allowing one to assess the generality of the paradigm based on the gradual accumulation of evidence. Here, I examine the relationship between the magnitude of published quantitative estimates of parasite-induced changes in host behaviour and year of publication from the time the adaptive host manipulation hypothesis was first proposed. Two independent data sets were used, both originally gathered for other purposes. First, across 137 comparisons between the behaviour of infected and uninfected hosts, the estimated relative influence of parasites correlated negatively with year of publication. This effect was contingent upon the transmission mode of the parasites studied. The negative relationship was very strong among studies of parasites which benefit from host manipulation (transmission to the next host occurs by predation on an infected intermediate host), i.e. among studies which were explicit tests of the adaptive manipulation hypothesis. There was no correlation with year of publication among studies on other types of parasites which do not seem to receive benefits from host manipulation. Second, among 14 estimates of the relative, parasite-mediated increase in transmission rate (i.e. increases in predation rates by definitive hosts on intermediate hosts), the estimated influence of parasites again correlated negatively with year of publication. These results have several possible explanations, but tend to suggest biases with regard to what results are published through time as accepted paradigms changed. 相似文献
63.
Steve Horvath Abu NM Nazmul-Hossain Rodney PE Pollard Frans GM Kroese Arjan Vissink Cees GM Kallenberg Fred KL Spijkervet Hendrika Bootsma Sara A Michie Sven U Gorr Ammon B Peck Chaochao Cai Hui Zhou David TW Wong 《Arthritis research & therapy》2012,14(6):1-13
Bone tissue has an exceptional quality to regenerate to native tissue in response to injury. However, the fracture repair process requires mechanical stability or a viable biological microenvironment or both to ensure successful healing to native tissue. An improved understanding of the molecular and cellular events that occur during bone repair and remodeling has led to the development of biologic agents that can augment the biological microenvironment and enhance bone repair. Orthobiologics, including stem cells, osteoinductive growth factors, osteoconductive matrices, and anabolic agents, are available clinically for accelerating fracture repair and treatment of compromised bone repair situations like delayed unions and nonunions. Preclinical and clinical studies using biologic agents like recombinant bone morphogenetic proteins have demonstrated an efficacy similar or better than that of autologous bone graft in acute fracture healing. A lack of standardized outcome measures for comparison of biologic agents in clinical fracture repair trials, frequent off-label use, and a limited understanding of the biological activity of these agents at the bone repair site have limited their efficacy in clinical applications. 相似文献
64.
Omar JM Hamza Mecky IN Matee Mainen J Moshi Elison NM Simon Ferdinand Mugusi Frans HM Mikx Wim H van Palenstein Helderman Antonius JMM Rijs André JAM van der Ven Paul E Verweij 《BMC microbiology》2008,8(1):135
Background
In Tanzania, little is known on the species distribution and antifungal susceptibility profiles of yeast isolates from HIV-infected patients with primary and recurrent oropharyngeal candidiasis. 相似文献65.
Ecosystem functioning, characterized by components such as productivity and stability, has been extensively linked with diversity in recent years, mainly in plant ecology. The aim of our study was thus to quantify general relationships between diversity, community structure and ecosystem functions in metazoan parasite communities. We used data on parasite communities from 15 species of marine fish hosts from coastal Chile. The volumetric abundance (volume of all parasite species per individual host, in mm3) was used as a surrogate for productivity. Species diversity was measured using both species richness and evenness, while community structure was estimated using the co‐occurrence indices V‐ratio, C‐score and a new C‐scores index standardized for the number of host replicates. After correcting for fish size, 47% of host species show no relationship, 13% show a hump shaped curve and 40% show positive monotonic relationships between productivity and parasite richness across all host individuals in a sample. We obtained a logarithmically decreasing relationship between evenness and productivity for all fish species, and propose a ‘dominance‐resistance’ hypothesis based on immunity to explain this pattern. The stability of the parasite community, measured as the coefficient of variation in productivity among individual hosts, was strongly and positively related to mean species richness across the 15 host species. The C‐scores index, based on the number of checkerboard units in the host‐parasite presence/absence matrix, increases linearly with mean productivity across the 15 host species, suggesting that parasite communities tend to be more structured when they are more productive. This is the likely reason why linear relationships between richness and productivity were not observed consistently in all fish species. Parasite communities provide some clear patterns for the diversity–ecosystem functioning debate in ecology, although other factors, such as the history of community assembly, may also influence these patterns. 相似文献
66.
We examined whether or not sizes of eggs and offspring were related to emergence date or maternal size in a semelparous aquatic
insect (the burrowing mayfly, Hexagenia) in which parental care is lacking and oviposited eggs are passively dispersed. We quantified the size of males and female
imagos over the emergence span at a site on the Detroit River, Canada, and investigated relationships between emergence date
and female size and (1) egg size and (2) size of first-instar nymphs. Although size of female imagos (H. limbata and H. rigida combined) declined significantly (P<0.025) over the emergence season, there was no significant relationship between body length and emergence date for males
of either species. Males were significantly (P<0.001) smaller than females. H. limbata eggs, subsampled from three individuals from each of three size classes of female imagos collected on seven sampling dates,
were measured using video image analysis. Eggs (n=100) oviposited by each of 63 H. limbata imagos were inspected daily for hatching. Newly hatched nymphs were removed, counted and measured. Egg size (P<0.001) and size of first-instar nymphs (P<0.001) varied significantly with emergence date, but not maternal size. The largest eggs and newly hatched nymphs occurred
at peak emergence of adults. The synchronous release of larger (faster-sinking) eggs may result in reduced predation. Plasticity
in egg development time and egg and nymph size may account for the ability of this taxon to recover from episodes of massive
population reduction.
Received: 12 March 1996 / Accepted: 24 February 1997 相似文献
67.
Several CD4 domains can play a role in human immunodeficiency virus infection in cells. 总被引:1,自引:4,他引:1
L Poulin L A Evans S B Tang A Barboza H Legg D R Littman J A Levy 《Journal of virology》1991,65(9):4893-4901
The human immunodefiency virus (HIV) uses the human CD4 glycoprotein as a receptor for infection of susceptible cells. Cells expressing a series of mutated forms of the CD4 gene have shown a variability in their ability to support replication of three HIV type 1 (HIV-1) and three HIV-2 strains. Moreover, when different stages of virus production were examined by a variety of assays, a consistent delay was observed in all cell lines containing CD4 mutants compared with those with intact full-length CD4. Cells expressing the CD4.415 mutant (modified at the serine 415 corresponding to a phosphorylation site of the cytoplasmic domain) showed only a minimal effect on virus replication. Cells expressing CD4.403 and CD4.401 mutants (lacking the whole cytoplasmic domain) manifested a moderate delay in production of virus progeny. The most substantial effect on HIV replication was observed in cells expressing a chimeric hybrid containing sequences corresponding to the first 177 residues of the N-terminal CD4 fused to CD8 sequences encoding the hinge, transmembrane, and cytoplasmic domains of the human CD8. Furthermore, in a cell-to-cell contact assay, fusion was absent when the CD4 proximal membrane domain was replaced by the CD8 counterpart. In addition, a strong correlation between the down-modulation of the surface CD4 and HIV expression was observed. These observations suggest that in addition to the known binding region, other domains of CD4 could play an important role in regulating HIV entry of cells. 相似文献
68.
69.
Vaitaitis GM Poulin M Sanderson RJ Haskins K Wagner DH 《Journal of immunology (Baltimore, Md. : 1950)》2003,170(7):3455-3459
It has been speculated that autoimmune diseases are caused by failure of central tolerance. However, this remains controversial. We have suggested that CD40 expression identifies autoaggressive T cells in the periphery of autoimmune prone mice. In this study, we report that CD40 was cloned from autoaggressive T cells and that engagement induces expression and nuclear translocation of the recombinases, recombination activating gene (RAG) 1 and RAG2 in the autoaggressive, but not in the nonautoaggressive, peripheral T cell population. Furthermore, we demonstrate that CD40 engagement induces altered TCR Valpha, but not Vbeta, expression in these cells. Therefore, CD40-regulated expression of RAG1 and RAG2 in peripheral T cells may constitute a novel pathway for the generation of autoaggressive T cells. 相似文献
70.
Antoine Filion Trudi Webster Robert Poulin Stephanie S. Godfrey 《Austral ecology》2023,48(7):1413-1425
The past few years have seen a noticeable increase in the emergence of infectious diseases in wildlife, especially vector-borne diseases, presenting a challenge for the conservation of endangered species. One such vector-borne disease, avian malaria (Plasmodium spp.) is on the rise in New Zealand avifauna, threatening bird populations that are among the most extinction-prone in the world. Furthermore, recent reports have outlined an increase in deaths of native iconic bird species specifically due to this disease. In order to help manage breakouts of this pathogen at a local scale, we need a better understanding of potential drivers of the emergence of avian malaria in wild New Zealand avifauna. Here, we set to test the role of climatic drivers in synchronizing contacts between avian hosts and vectors, assess the temporal stability of transmission dynamics between years, and determine the role of introduced species in causing spill-over of this pathogen towards native species. Our study focused on three sites that were sampled regularly during two consecutive years in the austral summer, each site being adjacent to a breeding colony of Yellow-eyed penguins (Megadyptes antipodes). Our results reveal an overall temporal stability of avian malaria incidence patterns, with a decrease in infection throughout the austral summer for both sampled years. Moreover, we highlight a phylogenetic signal among sampled bird species, with introduced species being more heavily infected by avian malaria than their native counterparts. In contrast, we found no effect of the two climatic drivers investigated, temperature and rainfall, on mosquito abundance. Our results suggest a strong effect of alien species acting as reservoirs for diseases spilling-over towards immunologically naïve species, and provide conservation managers with a critical timeframe to control avian malaria breakouts. 相似文献