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91.
Balaban PM Malyshev AY Ierusalimsky VN Aseyev N Korshunova TA Bravarenko NI Lemak MS Roshchin M Zakharov IS Popova Y Boyle R 《PloS one》2011,6(3):e17710
Background
The mollusk statocyst is a mechanosensing organ detecting the animal''s orientation with respect to gravity. This system has clear similarities to its vertebrate counterparts: a weight-lending mass, an epithelial layer containing small supporting cells and the large sensory hair cells, and an output eliciting compensatory body reflexes to perturbations.Methodology/Principal Findings
In terrestrial gastropod snail we studied the impact of 16- (Foton M-2) and 12-day (Foton M-3) exposure to microgravity in unmanned orbital missions on: (i) the whole animal behavior (Helix lucorum L.), (ii) the statoreceptor responses to tilt in an isolated neural preparation (Helix lucorum L.), and (iii) the differential expression of the Helix pedal peptide (HPep) and the tetrapeptide FMRFamide genes in neural structures (Helix aspersa L.). Experiments were performed 13–42 hours after return to Earth. Latency of body re-orientation to sudden 90° head-down pitch was significantly reduced in postflight snails indicating an enhanced negative gravitaxis response. Statoreceptor responses to tilt in postflight snails were independent of motion direction, in contrast to a directional preference observed in control animals. Positive relation between tilt velocity and firing rate was observed in both control and postflight snails, but the response magnitude was significantly larger in postflight snails indicating an enhanced sensitivity to acceleration. A significant increase in mRNA expression of the gene encoding HPep, a peptide linked to ciliary beating, in statoreceptors was observed in postflight snails; no differential expression of the gene encoding FMRFamide, a possible neurotransmission modulator, was observed.Conclusions/Significance
Upregulation of statocyst function in snails following microgravity exposure parallels that observed in vertebrates suggesting fundamental principles underlie gravi-sensing and the organism''s ability to adapt to gravity changes. This simple animal model offers the possibility to describe general subcellular mechanisms of nervous system''s response to conditions on Earth and in space. 相似文献92.
93.
Losanka P. Popova William H. Outlaw Jr. Karthik Aghoram Daniel R. C. Hite 《Physiologia plantarum》2000,108(4):376-381
Physiological aspects of abscisic acid (ABA) as a drought signal directed specifically at guard cells are topical research foci. Most investigations concentrate on the importance of remote sources of ABA against the background knowledge that leaves are also a source of ABA. Foliar compartmentation of ABA and water-stress-induced release of cellular ABA into the apoplast imply additional levels of complexity. In the present study, we established that the pre-existing foliar ABA pool can be moved to guard cells. We detached leaflets of Vicia faba L. to eliminate an external source of ABA. The leaflets were then pretreated with cycloheximide (CHI), an inhibitor of protein biosynthesis that abolished ABA accumulation in the leaflets. Next, the leaflets were water stressed. After incubation, leaflets were snap-frozen and freeze-dried. Guard cells were individually dissected from the leaflets; such guard-cell samples contain both apoplastic and symplastic ABA. The ABA content of guard cells of CHI-treated, water-stressed leaflets was less than that of control water-stressed leaflets, but higher than that of control water-sufficient leaflets, indicating that guard cells are targets of intraleaf ABA redistribution under stress. 相似文献
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96.
Nakvasina MA Popova LI Golub NV Artiukhov VG 《Radiatsionnaia biologiia, radioecologiia / Rossi?skaia akademiia nauk》2005,45(2):174-179
The changes of photo- and peroxide resistance of erythrocytic and lymphocytic cells of human under influence of UV and some active oxygen forms in presence of biogenic amines such as serotonin, dopamine, adrenalin, histamine had been investigated. While investigating the degree of photohemolysis of erythrocytes it was discovered that biogenic compounds raise UV stability of erythrocytic membranes. By using the method of chemiluminescence it was established that biogenic amines increased the degree of peroxide resistance of human erythrocytic and lymphocytic cells. The decrease of the level of erythrocytic diene conjugates under influence of UV by serotonin and histamine was also discovered. 相似文献
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98.
Muntyan MS Popova IV Bloch DA Skripnikova EV Ustiyan VS 《Biochemistry. Biokhimii?a》2005,70(2):137-142
Cytochrome and lipid composition of membranes is considered as the attributes required for adaptation of the alkalophiles to alkaline conditions. Respiratory chains of alkalophilic representatives of the genus Bacillus are discussed. Special attention is paid to the features of the Na+-cycle of these bacteria and to the features determining halo- and alkalotolerant phenotype, which have been reported due to recent achievements in genomics.Translated from Biokhimiya, Vol. 70, No. 2, 2005, pp. 171–176.Original Russian Text Copyright © 2005 by Muntyan, Popova, Bloch, Skripnikova, Ustiyan.This revised version was published online in April 2005 with corrections to the post codes. 相似文献
99.
Immobility reaction or catalepsy is a natural passive defensive (lurking) behavioral response to the appearance of a predator. Selection for high predisposition to catalepsy has been performed in a population of (CBA x (CBA x AKR)) backcrosses of the crossing between mouse lines sensitive and resistant to catalepsy (VBA and AKR, respectively). A rapid increase in the number of animals with catalepsy has been observed: from 23% in backcrosses to 71% in the S3 generation. Selection for catalepsy does not affect mouse anxiety in the open field and plus-maze tests. However, S8 and S9 mice are characterized by a decreased motor activity in the open-field test and an increased immobility in the forced swim and tail suspension tests, which is interpreted as an increase in "depressiveness." The results indicate that genetically determined catalepsy is related to depressive-like characteristics of defensive behavior. 相似文献
100.
The origin of multiaberrant cells (MACs) was studied by comparing the structure and intensity of chromosome damage in peripheral blood lymphocytes of two groups of people: workers of Siberian Chemical Plant differing in the content of plutonium-239 in their bodies, and inhabitants of a non-polluted settlement (control group). Plutonium-239 is known to be a long-lived densely-ionizing source of alpha-radiation with high linear energy delivery; therefore, it has a stronger effect on cell hereditary structures than gamma-rays. In persons with the content of plutonium-239 higher than 13 nCu, the frequency of MAC was 0.105% which at least tenfold exceeds the spontaneous level. The chromosome-type aberrations that are usually induced by ionizing radiation predominated in MACs. Our results suggest that MAC formation may be caused by internal body irradiation with the incorporated sources of densely-ionizing radiation. 相似文献