全文获取类型
收费全文 | 601篇 |
免费 | 29篇 |
出版年
2023年 | 3篇 |
2022年 | 15篇 |
2021年 | 23篇 |
2020年 | 12篇 |
2019年 | 13篇 |
2018年 | 21篇 |
2017年 | 21篇 |
2016年 | 24篇 |
2015年 | 30篇 |
2014年 | 35篇 |
2013年 | 39篇 |
2012年 | 55篇 |
2011年 | 40篇 |
2010年 | 21篇 |
2009年 | 11篇 |
2008年 | 21篇 |
2007年 | 24篇 |
2006年 | 28篇 |
2005年 | 23篇 |
2004年 | 22篇 |
2003年 | 14篇 |
2002年 | 19篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 8篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1979年 | 2篇 |
1977年 | 4篇 |
1974年 | 4篇 |
1969年 | 3篇 |
1959年 | 2篇 |
1958年 | 2篇 |
1957年 | 4篇 |
1956年 | 2篇 |
排序方式: 共有630条查询结果,搜索用时 671 毫秒
181.
Tarun Mehra Christian Thomas Benedikt Müller J?rk Volbracht Burkhardt Seifert Rudolf Moos 《PloS one》2015,10(10)
Principles
Case weights of Diagnosis Related Groups (DRGs) are determined by the average cost of cases from a previous billing period. However, a significant amount of cases are largely over- or underfunded. We therefore decided to analyze earning outliers of our hospital as to search for predictors enabling a better grouping under SwissDRG.Methods
28,893 inpatient cases without additional private insurance discharged from our hospital in 2012 were included in our analysis. Outliers were defined by the interquartile range method. Predictors for deficit and profit outliers were determined with logistic regressions. Predictors were shortlisted with the LASSO regularized logistic regression method and compared to results of Random forest analysis. 10 of these parameters were selected for quantile regression analysis as to quantify their impact on earnings.Results
Psychiatric diagnosis and admission as an emergency case were significant predictors for higher deficit with negative regression coefficients for all analyzed quantiles (p<0.001). Admission from an external health care provider was a significant predictor for a higher deficit in all but the 90% quantile (p<0.001 for Q10, Q20, Q50, Q80 and p = 0.0017 for Q90). Burns predicted higher earnings for cases which were favorably remunerated (p<0.001 for the 90% quantile). Osteoporosis predicted a higher deficit in the most underfunded cases, but did not predict differences in earnings for balanced or profitable cases (Q10 and Q20: p<0.00, Q50: p = 0.10, Q80: p = 0.88 and Q90: p = 0.52). ICU stay, mechanical and patient clinical complexity level score (PCCL) predicted higher losses at the 10% quantile but also higher profits at the 90% quantile (p<0.001).Conclusion
We suggest considering psychiatric diagnosis, admission as an emergencay case and admission from an external health care provider as DRG split criteria as they predict large, consistent and significant losses. 相似文献182.
183.
184.
Tiwari Jagesh Kumar Devi Sapna Sharma Sanjeev Chandel Poonam Rawat Shashi Singh Bir Pal 《Plant Molecular Biology Reporter》2015,33(5):1584-1598
Plant Molecular Biology Reporter - The late blight disease can be managed by introduction of resistance (R) genes from the wild Solanum species into the cultivated potato. The R genes are mostly... 相似文献
185.
The host inflammatory response appears to be an important contributor to the pathogenesis of human viral respiratory illness. Virus-induced oxidative stress appears to mediate an early phase of elaboration of the proinflammatory cytokine interleukin-8 by respiratory epithelial cells. The purpose of these studies was to determine if virus-induced alterations in either the expression or function of antioxidant enzymes contributes to the cellular oxidative stress following rhinovirus challenge. The activities of Mn superoxide dismutase (MnSOD), catalase and glutathione peroxidase (GPX) were not significantly changed by rhinovirus challenge. CuZn superoxide dismutase (CuZnSOD) activity six hours after challenge was 2.55 - 0.56 U/mg protein in rhinovirus-challenged cells compared to 1.16 - 0.54 U/mg protein in control cells ( p =0.029). This increased activity was associated with a concomitant increase in CuZnSOD mRNA and protein concentration. These data suggest that rhinovirus-induced changes in the host cell redox state that result in the early elaboration of interleukin-8 are not mediated by inhibition of either the expression or function of these antioxidant enzymes. 相似文献
186.
Kumawat Surbhi Aggarwal Bharti Rana Nitika Mandlik Rushil Mehra Akrity Shivaraj S. M. Sonah Humira Deshmukh Rupesh 《Journal of plant biochemistry and biotechnology.》2021,30(4):930-942
Journal of Plant Biochemistry and Biotechnology - Aquaporins (AQPs), pore-forming proteins, are known to involve in the transport of water and many other small solutes, and play a diverse role in... 相似文献
187.
Rajpoot Ritika Srivastava Rajneesh Kumar Rani Anjana Pandey Poonam Dubey R. S. 《Protoplasma》2021,258(2):319-335
Protoplasma - Manganese (Mn) is an essential element for plant growth but it becomes phytotoxic at higher concentrations. The effect of Mn-excess in hydroponics medium was examined on growth,... 相似文献
188.
Ahmad Raza Khan Poonam Rana Ritu Tyagi Indracanti Prem Kumar M. Memita Devi Salim Javed Rajendra P. Tripathi Subash Khushu 《Metabolomics : Official journal of the Metabolomic Society》2011,7(4):583-592
Radiation accidents are rare events that induce radiation syndrome, a complex pathology which is difficult to treat. In medical
management of radiation victims, life threatening damage to different physiological systems should be taken into consideration.
The present study was proposed to identify metabolic and physiological perturbations in biofluids of mice during different
phases of radiation sickness using 1H nuclear magnetic resonance (1H NMR) spectroscopy and pattern recognition (PR) technique. The 1H NMR spectra of the biofluids collected from mice irradiated with 5 Gray (Gy) at different time points during radiation sickness
were analysed visually and by principal components analysis. Urine and serum spectral profile clearly showed altered metabolic
profiles during different phases of radiation sickness. Increased concentration of urine metabolites viz. citrate, α ketoglutarate,
succinate, hippurate, and trimethylamine during prodromal and clinical manifestation phase of radiation sickness shows altered
gut microflora and energy metabolism. On the other hand, serum nuclear magnetic resonance (NMR) spectra reflected changes
associated with lipid, energy and membrane metabolism during radiation sickness. The metabonomic time trajectory based on
PR analysis of 1H NMR spectra of urine illustrates clear separation of irradiated mice group at different time points from pre dose. The difference
in NMR spectral profiles depicts the pathophysiological changes and metabolic disturbances observed during different phases
of radiation sickness, that in turn, demonstrate involvement of multiple organ dysfunction. This could further be useful in
development of multiparametric approach for better evaluation of radiation damage as well as for medical management during
radiation sickness. 相似文献
189.
Marchant BK Reimherr FW Halls C Williams ED Strong RE Kondo D Soni P Robison RJ 《Attention deficit and hyperactivity disorders》2011,3(3):237-244
A three-year open-label study of atomoxetine in adults with ADHD followed two multicenter, double-blind trials. In the double-blind trials, female gender and higher levels of emotional symptoms were associated with better outcome. Following a 4-week placebo washout period, 384 (of 536) subjects continued into the open-label study. 61% of subjects entering this open-label study remained after 6?months at an average dose of 100?mg/day. Subjects who had previously responded to double-blind atomoxetine achieved maximum response after 8?weeks of open-label medication, but others continued to improve for 36?weeks. Women improved more (7.7?±?6.4) than men (6.1?±?6.4) on the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) (P?=?.007) and the Conners' Adult ADHD Rating Scale (P?=?.03). Subjects with emotional dysregulation improved more than others on the WRAADDS (P?=?.001). Responders ultimately improved approximately 60% in attentional, hyperactive/impulsive, and emotional symptoms. Thirty-nine percent of atomoxetine double-blind non-responders became responders during open-label treatment. 相似文献
190.
The sequential events and the inflammatory mediators that characterize disease onset and progression of ulcerative colitis (UC) are not well known. In this study, we evaluated the early pathologic events in the pathogenesis of colonic ulcers in rats treated with dextran sodium sulfate (DSS). Following a lag phase, day 5 of DSS treatment was found clinically most critical as disease activity index (DAI) exhibited an exponential rise with severe weight loss and rectal bleeding. Surprisingly, on days 1-2, colonic TNF-α expression (70-80-fold) and tissue protein (50-fold) were increased, whereas IL-1β only increased on days 7-9 (60-90-fold). Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFβ) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin. Remarkably, treatment with TNF-α neutralizing antibody markedly altered DSS injury with reduced DAI, restoration of the adherent and goblet cell mucin and IL-1β and mucin gene expression. We conclude that early onset colitis is dependent on TNF-α that preceded depletion of adherent and goblet cell mucin prior to epithelial cell damage and these biomarkers can be used as therapeutic targets for UC. 相似文献