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841.
Rodrigo Reis Mota Paulo Sávio Lopes Luiz Fernando Aar?o Marques Luciano Pinheiro da Silva Marcos Deon Vilela de Resende Robledo de Almeida Torres 《Genetics and molecular biology》2013,36(1):43-49
The weight records from Simmental beef cattle were used in a genetic evaluation of growth with or without the inclusion of animals obtained by embryo transfer. A multi-trait model in which embryo transfer individuals were excluded (MTM1) contained 29,510 records from 10,659 animals, while another model without exclusion of these animals (MTM2) contained 62,895 weight records from 23,160 animals. The weight records were adjusted for ages of 100, 205, 365, 450, 550 and 730 days. The (co)variance components and genetic parameters were estimated by the restricted maximum likelihood method. The (co)variance components were similar in both models, except for maternal permanent environment variance. Direct heritabilities (h2d) in MTM1 were 0.04, 0.11, 0.20, 0.27, 0.31 and 0.42, while in MTM2 they were 0.11, 0.11, 0.17, 0.21, 0.22 and 0.26 for 100, 205, 365, 450, 550 and 730 days of age, respectively. Estimates of h2d in MTM1 were higher than in MTM2 for the weight at 365 days of age. Genetic correlations between weights in both models ranged from moderate to high, suggesting that these traits may be determined mainly by the same genes. Animals from embryo transfer may be included in the genetic evaluation of Simmental beef cattle in Brazil; this inclusion may provide potential gains in accuracy and genetic gains by reducing the interval between generations. 相似文献
842.
Michael Williams Leal Quirino Michelly Cristiny Pereira Maria de Ftima Deodato de Souza Ivan da Rocha Pitta Antnio Felix da Silva Filho Mrio S. de Souza Albuquerque Amanda Pinheiro de Barros Albuquerque Mrio Rino Martins Maira Galdino da Rocha Pitta Moacyr Jesus Barreto de Melo Rêgo 《European journal of histochemistry : EJH》2021,65(1)
The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target for cancer immunotherapy in several tumor types. The present study aimed to investigate Siglec-15 expression in gastric cancer (GC) patient tissues and to evaluate its clinical value. Siglec-15 expression was evaluated by immunohistochemistry in 71 patients. Siglec-15 staining was observed in tumor cells of 53 (74.64%) patients, with significant association with histologic classification and angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected Siglec-15 in tumor-associated stroma cells (macrophages/myeloid cells). There was no significant association with outcome parameters. Siglec-15 expression in well differentiated histological GC tissues and in the tumor microenvironment are potential targets to be further investigated as a novel prognostic factor for GC.Key words: Siglec, sialic acid, immunohistochemistry, clinical-pathological analyses 相似文献
843.
Lena Marie Westermann Lutz Fleischhauer Jonas Vogel Zsuzsa Jenei-Lanzl Nataniel Floriano Ludwig Lynn Schau Fabio Morellini Anke Baranowsky Timur A. Yorgan Giorgia Di Lorenzo Michaela Schweizer Bruna de Souza Pinheiro Nicole Ruas Guarany Fernanda Sperb-Ludwig Fernanda Visioli Thiago Oliveira Silva Jamie Soul Gretl Hendrickx J. Simon Wiegert Ida V. D. Schwartz Hauke Clausen-Schaumann Frank Zaucke Thorsten Schinke Sandra Pohl Tatyana Danyukova 《Disease models & mechanisms》2020,13(11)
844.
845.
Carina Mori Frade Gomes Maria Teresa Terreri Maria Isabel de Moraes-Pinto Cássia Barbosa Natália Pereira Machado Maria Roberta Melo Marcelo Medeiros Pinheiro 《Memórias do Instituto Oswaldo Cruz》2015,110(7):921-928
Several studies point to the increased risk of reactivation of latent tuberculosis
infection (LTBI) in patients with chronic inflammatory arthritis (CIAs) after using
tumour necrosis factor (TNF)α blockers. To study the incidence of
active mycobacterial infections (aMI) in patients starting TNF α
blockers, 262 patients were included in this study: 109 with rheumatoid arthritis
(RA), 93 with ankylosing spondylitis (AS), 44 with juvenile idiopathic arthritis
(JIA) and 16 with psoriatic arthritis (PsA). All patients had indication for anti-TNF
α therapy. Epidemiologic and clinical data were evaluated and a
simple X-ray and tuberculin skin test (TST) were performed. The control group
included 215 healthy individuals. The follow-up was 48 months to identify cases of
aMI. TST positivity was higher in patients with AS (37.6%) than in RA (12.8%), PsA
(18.8%) and JIA (6.8%) (p < 0.001). In the control group, TST positivity was
32.7%. Nine (3.43%) patients were diagnosed with aMI. The overall incidence rate of
aMI was 86.93/100,000 person-years [95% confidence interval (CI) 23.6-217.9] for
patients and 35.79/100,000 person-years (95% CI 12.4-69.6) for control group (p <
0.001). All patients who developed aMI had no evidence of LTBI at the baseline
evaluation. Patients with CIA starting TNF α blockers and no
evidence of LTBI at baseline, particularly with nonreactive TST, may have higher risk
of aMI. 相似文献
846.
Felipe Jules de Araujo Luan Diego Oliveira da Silva Tirza Gabrielle Mesquita Suzana Kanawati Pinheiro Wonei de Seixas Vital Anette Chrusciak-Talhari Jorge Augusto de Oliveira Guerra Sinésio Talhari Rajendranath Ramasawmy 《PLoS neglected tropical diseases》2015,9(6)
IntroductionThe clinical outcome to Leishmania-infection is determined by the individual adaptive immune T helper cell responses and their interactions with parasitized host cells. An early development of a proinflammatory immune response (Th1 response) is necessary for Leishmania-infection resolution. The Toll-interacting protein (TOLLIP) regulates human Toll-like receptors signaling pathways by down regulating the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and inducing the ant-inflammatory cytokine interleukin-10 (IL-10). Polymorphisms in the TOLLIP gene are associated with infectious diseases.ResultsThe G and T alleles of the rs5743899 and rs3750920 were more common in patients with CL than in healthy individuals (P = 2.6 x10-8 ; odds ratio [OR], 1.7 [ 95% confidence interval (CI) 1.4–2.0] and P = 1.9 x10-8 ; OR, 1.6 [95% CI 1.4–1.9] respectively). The r2 and D’ linkage disequilibrium between the two polymorphisms are 0.05 and 0.473 with a confidence bounds of 0.37 to 0.57 respectively.ConclusionThe two polymorphisms are independently associated with an increased risk of developing CL. 相似文献
847.
Pempheris
gasparinii
sp. n. is described from five specimens, 59.1–68.0 mm in standard length. It is only known to occur in the shallow reefs of Trindade Island, 1200 km east of the Brazilian coast, in the southwestern Atlantic. Pempheris
gasparinii is the third recognized species of Pempheris in the Atlantic Ocean. This new species is morphologically similar to its close relative, Pempheris
poeyi, differing by the number of lateral-line scales (51–54 in Pempheris
gasparinii vs. 47–49 in Pempheris
poeyi), scales below lateral line (10–11 vs. 9), circumpeduncular scales (11–12 vs. 13), head and caudal peduncle lengths (2.7–3.3 vs 3.5–4.0 in head length). Moreover, Pempheris
gasparinii shows a 4% genetic divergence from Pempheris
poeyi at the cytochrome oxidase I locus (COI), consistent with a lineage split at the beginning of the Pleistocene. This new species represents the 12th endemic fish species from Trindade Island. 相似文献
848.
Assessment of instream structures for habitat improvement for two critically endangered fish species 总被引:1,自引:0,他引:1
I. Boavida J. M. Santos R. V. Cortes A. N. Pinheiro M. T. Ferreira 《Aquatic Ecology》2011,45(1):113-124
The number of fish habitat improvement schemes has greatly increased in response to the widespread degradation of aquatic
ecosystems. However, many of these enhancement projects often fail to create expected habitat conditions, because they are
rarely planned and executed with inputs from the species’ habitat requirements throughout their life histories, and it is
frequently assumed that the implementation of a specific instream structure for habitat improvement will always benefit all
species present. Using a 2D hydraulic model, the present study evaluates the potential habitat improvement for two critically
endangered fish species—the Southwestern arched-mouth nase Iberochondrostoma almacai and the Arade chub Squalius aradensis—resulting from simulating the introduction of different instream structures (islands, lateral bays, and deflectors) in a
modified Mediterranean river reach. The introduction of islands in the river channel was found to be the best improvement
measure for YOY and juvenile nase and chub, as shown by increases in the mean annual Weighted Usable Area (WUA) of more than
100 and 50%, respectively, compared to the present conditions. On the other hand, the simulation with current deflectors proved
to be the worst scenario, particularly for nase, with mean annual WUA decreasing by 3.6, 17.8 and 22.7% for YOY, juveniles
and adults, respectively. The findings of this study point to the need to account for different species life-history stages
when modelling the implementation of instream structures for habitat improvement and also provide a sound basis for future
conservation-related studies conducted in Mediterranean rivers that harbour other threatened “sister” species. 相似文献
849.
Patricia Nessralla Alpoim Melina de Barros Pinheiro Daniela Rezende Garcia Junqueira Leticia Gonçalves Freitas Maria das Graças Carvalho Ana Paula Salles Moura Fernandes Flávia Komatsuzaki Karina Braga Gomes Luci Maria Sant’Ana Dusse 《Molecular biology reports》2013,40(3):2253-2261
Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis. 相似文献
850.
Ferreira Eskálath Morganna Silva de Sousa Francisca Maria Pinheiro Rosa Luiz Henrique Pimenta Raphael Sanzio 《Extremophiles : life under extreme conditions》2019,23(1):151-159
Extremophiles - The interest in the diversity of yeasts in the Antarctic environment has increased in recent years, mainly because Antarctic microbiology is a recent science, and little is known... 相似文献