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41.
Jessica AB van Nies Rute B Marques Stella Trompet Zuzana de Jong Fina AS Kurreeman Rene EM Toes J Wouter Jukema Tom WJ Huizinga Annette HM van der Helm-van Mil 《Arthritis research & therapy》2010,12(2):R38
Introduction
Recently an association between a genetic variation in TRAF1/C5 and mortality from sepsis or cancer was found in rheumatoid arthritis (RA). The most prevalent cause of death, cardiovascular disease, may have been missed in that study, since patients were enrolled at an advanced disease stage. Therefore, we used an inception cohort of RA patients to investigate the association between TRAF1/C5 and cardiovascular mortality, and replicate the findings on all-cause mortality. As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients. 相似文献42.
dos Santos Vagner Leonardo Macêdo Catelani Paula Araujo Petry Ana Cristina Caramaschi Érica Maria Pellegrini 《Hydrobiologia》2021,848(9):2383-2397
Hydrobiologia - With the aim of assessing whether hydrological alterations differently affect non-native and native fish species in coastal systems, we investigated fish assemblages along the... 相似文献
43.
44.
In the world scenario of declining grassland bird populations, South American species are a particular concern. The Saffron-Cowled
Blackbird Xanthopsar flavus is endemic to grasslands in Central and southern South America and its status is vulnerable. Natural history studies stress
a number of factors responsible for the decline in its populations. In this paper, we present results from a grassland fire
experiment aimed at evaluating the effect of grassland fires on foraging (grasses) and breeding (marshes) habitat use by the
Saffron-Cowled Blackbird in a region where fire has been used for centuries as a tool for cattle management. We compare burned
grasslands with a control treatment and grasslands within a conservation unit, evaluating uses before and after burning as
well as relating bird abundance with environmental characteristics. We found that the Saffron-Cowled Blackbird used the burned
treatments more frequently and avoided habitats with tall grasses and developed vegetation. Thus, this species is absent from
the conservation unit, which has not experienced fires in nearly three decades. The Saffron-Cowled Blackbird depends on the
existence of marshes (breeding habitat) surrounded by short grasses (foraging habitat). In the study region, short grasses
are a result of burning practices. As the burning period coincides with the breeding season, the lack of criteria on the part
of landowners regarding how to apply and control fire poses a permanent threat to these populations. 相似文献
45.
Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration 总被引:1,自引:0,他引:1
46.
Hébert L Moumen B Pons N Duquesne F Breuil MF Goux D Batto JM Laugier C Renault P Petry S 《PloS one》2012,7(1):e29953
The Taylorella genus comprises two species: Taylorella equigenitalis, which causes contagious equine metritis, and Taylorella asinigenitalis, a closely-related species mainly found in donkeys. We herein report on the first genome sequence of T. asinigenitalis, analyzing and comparing it with the recently-sequenced T. equigenitalis genome. The T. asinigenitalis genome contains a single circular chromosome of 1,638,559 bp with a 38.3% GC content and 1,534 coding sequences (CDS). While 212 CDSs were T. asinigenitalis-specific, 1,322 had orthologs in T. equigenitalis. Two hundred and thirty-four T. equigenitalis CDSs had no orthologs in T. asinigenitalis. Analysis of the basic nutrition metabolism of both Taylorella species showed that malate, glutamate and alpha-ketoglutarate may be their main carbon and energy sources. For both species, we identified four different secretion systems and several proteins potentially involved in binding and colonization of host cells, suggesting a strong potential for interaction with their host. T. equigenitalis seems better-equipped than T. asinigenitalis in terms of virulence since we identified numerous proteins potentially involved in pathogenicity, including hemagluttinin-related proteins, a type IV secretion system, TonB-dependent lactoferrin and transferrin receptors, and YadA and Hep_Hag domains containing proteins. This is the first molecular characterization of Taylorella genus members, and the first molecular identification of factors potentially involved in T. asinigenitalis and T. equigenitalis pathogenicity and host colonization. This study facilitates a genetic understanding of growth phenotypes, animal host preference and pathogenic capacity, paving the way for future functional investigations into this largely unknown genus. 相似文献
47.
The anatomy of the epigastric flap in the experimental rat 总被引:5,自引:0,他引:5
48.
49.
Jeanine A Verbunt Henk AM Seelen Feljandro P Ramos Bernard HM Michielsen Wim L Wetzelaer Martine Moennekens 《BMC neurology》2008,8(1):7
Background
Over 50% of patients with upper limb paresis resulting from stroke face long-term impaired arm function and ensuing disability in daily life. Unfortunately, the number of effective treatments aimed at improving arm function due to stroke is still low. This study aims to evaluate a new therapy for improving arm function in sub-acute stroke patients based on mental practice theories and functional task-oriented training, and to study the predictors for a positive treatment result. It is hypothesized that a six-week, mental practice-based training program (additional to regular therapy) targeting the specific upper extremity skills important to the individual patient will significantly improve both arm function and daily activity performance, as well as being cost effective. 相似文献50.
BD Connolly C Petry S Yadav B Demeule N Ciaccio JM Moore SJ Shire YR Gokarn 《Biophysical journal》2012,103(1):69-78
Weak protein-protein interactions are thought to modulate the viscoelastic properties of concentrated antibody solutions. Predicting the viscoelastic behavior of concentrated antibodies from their dilute solution behavior is of significant interest and remains a challenge. Here, we show that the diffusion interaction parameter (k(D)), a component of the osmotic second virial coefficient (B(2)) that is amenable to high-throughput measurement in dilute solutions, correlates well with the viscosity of concentrated monoclonal antibody (mAb) solutions. We measured the k(D) of 29 different mAbs (IgG(1) and IgG(4)) in four different solvent conditions (low and high ion normality) and found a linear dependence between k(D) and the exponential coefficient that describes the viscosity concentration profiles (|R| ≥ 0.9). Through experimentally measured effective charge measurements, under low ion normality where the electroviscous effect can dominate, we show that the mAb solution viscosity is poorly correlated with the mAb net charge (|R| ≤ 0.6). With this large data set, our results provide compelling evidence in support of weak intermolecular interactions, in contrast to the notion that the electroviscous effect is important in governing the viscoelastic behavior of concentrated mAb solutions. Our approach is particularly applicable as a screening tool for selecting mAbs with desirable viscosity properties early during lead candidate selection. 相似文献