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51.
Effects of treatment with Maraviroc a CCR5 inhibitor on a human hepatic stellate cell line 下载免费PDF全文
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Faithful initiation of ribosomal RNA transcription from cloned DNA by purified RNA polymerase I 总被引:8,自引:0,他引:8
M R Paule C T Iida P J Perna G H Harris S L Brown Shimer P Kownin 《Biochemistry》1984,23(18):4167-4172
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Jacob S. Ishay Bice Perna Yosef Hochberg Mina Goldstein 《Bulletin of mathematical biology》1980,42(5):681-689
The “yellow strips” on the cuticle of the Oriental Hornet (Vespa orientalis, Hymenoptera, Vespinae), present photoelectric properties. A mathematical model for the relative changes in resistance as
a photoconductive process conforms to the general model for a semiconductor with traps. 相似文献
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Vincenzo Esposito Lucrezia Manente Angelica Perna Miriam Gargiulo Rosaria Viglietti Vincenzo Sangiovanni Nectaria Doula Giuseppina Liuzzi Alfonso Baldi Antonio De Luca Antonio Chirianni 《Differentiation; research in biological diversity》2009
The pathogenetic bases of HAART-associated lipodystrophy are still poorly known, even if it is clear that adipose tissue and its metabolism are sensitive to antiretroviral therapy alone and/or in combination with HIV infection. The NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression, morphogenesis and tumorigenesis. We investigated the possible involvement of NEED8 in adipogenesis and, consequently, in HIV-related lipodystrophy. 相似文献
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Trudy Torto-Alalibo Candace W. Collmer Michelle Gwinn-Giglio Magdalen Lindeberg Shaowu Meng Marcus C. Chibucos Tsai-Tien Tseng Jane Lomax Bryan Biehl Amelia Ireland David Bird Ralph A. Dean Jeremy D. Glasner Nicole Perna Joao C. Setubal Alan Collmer Brett M. Tyler 《Microbiology and molecular biology reviews》2010,74(4):479-503
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Christian R. Voolstra Carol Buitrago‐Lpez Gabriela Perna Anny Crdenas Benjamin C. C. Hume Nils Rdecker Daniel J. Barshis 《Global Change Biology》2020,26(8):4328-4343
Coral bleaching is one of the main drivers of reef degradation. Most corals bleach and suffer mortality at just 1–2°C above their maximum monthly mean temperatures, but some species and genotypes resist or recover better than others. Here, we conducted a series of 18‐hr short‐term acute heat stress assays side‐by‐side with a 21‐day long‐term heat stress experiment to assess the ability of both approaches to resolve coral thermotolerance differences reflective of in situ reef temperature thresholds. Using a suite of physiological parameters (photosynthetic efficiency, coral whitening, chlorophyll a, host protein, algal symbiont counts, and algal type association), we assessed bleaching susceptibility of Stylophora pistillata colonies from the windward/exposed and leeward/protected sites of a nearshore coral reef in the central Red Sea, which had previously shown differential mortality during a natural bleaching event. Photosynthetic efficiency was most indicative of the expected higher thermal tolerance in corals from the protected reef site, denoted by an increased retention of dark‐adapted maximum quantum yields at higher temperatures. These differences were resolved using both experimental setups, as corroborated by a positive linear relationship, not observed for the other parameters. Notably, short‐term acute heat stress assays resolved per‐colony (genotype) differences that may have been masked by acclimation effects in the long‐term experiment. Using our newly developed portable experimental system termed the Coral Bleaching Automated Stress System (CBASS), we thus highlight the potential of mobile, standardized short‐term acute heat stress assays to resolve fine‐scale differences in coral thermotolerance. Accordingly, such a system may be suitable for large‐scale determination and complement existing approaches to identify resilient genotypes/reefs for downstream experimental examination and prioritization of reef sites for conservation/restoration. Development of such a framework is consistent with the recommendations of the National Academy of Sciences and the Reef Restoration and Adaptation Program committees for new intervention and restoration strategies. 相似文献