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排序方式: 共有498条查询结果,搜索用时 15 毫秒
491.
Ann T. Sweeney Samara Pena Jeena Sandeep Bryan Hernandez Ye Chen Janis L. Breeze Aysegul Bulut Karen Feghali Moaz Abdelrehim Mohamed Abdelazeem Padmavathi Srivoleti Linda Salvucci Susan Berry Cann Catalina Norman 《Endocrine practice》2022,28(6):615-621
ObjectiveContinuous glucose monitoring (CGM) has demonstrated benefits in managing inpatient diabetes. We initiated this single-arm pilot feasibility study during the COVID-19 pandemic in 11 patients with diabetes to determine the feasibility and accuracy of real-time CGM in patients who underwent cardiac surgery and whose care was being transitioned from the intensive care unit.MethodsA Clarke error grid analysis was used to compare CGM and point-of-care measurements. The mean absolute relative difference (MARD) of the paired measurements was calculated to assess the accuracy of CGM for glucose measurements during the first 24 hours on CGM, the remaining time on CGM, and for different chronic kidney disease (CKD) strata.ResultsOverall MARD between point-of-care and CGM measurements was 14.80%. MARD for patients without CKD IV and V with an estimated glomerular filtration rate (eGFR) of ≥20 mL/min/1.73 m2 was 12.13%. Overall, 97% of the CGM values were within the no-risk zone of the Clarke error grid analysis. For the first 24 hours, a sensitivity analysis of the overall MARD for all patients and those with an eGFR of ≥20 mL/min/1.73 m2 was 15.42% ± 14.44% and 12.80% ± 7.85%, respectively. Beyond the first 24 hours, overall MARD for all patients and those with an eGFR of ≥20 mL/min/1.73 m2 was 14.54% ± 13.21% and 11.86% ± 7.64%, respectively.ConclusionCGM has shown great promise in optimizing inpatient diabetes management in the noncritical care setting and after the transition of care from the intensive care unit with high clinical reliability and accuracy. More studies are needed to further assess CGM in patients with advanced CKD. 相似文献
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494.
Plasma fibronectin from 500 blood donors was studied by immunoelectrophoresis. No variants were found. Plasma fibronectin does not appear to be electrophoretically polymorphic in humans. 相似文献
495.
Joint effects of porcine leptin and leptin receptor polymorphisms on productivity and quality traits
D. Pérez‐Montarelo A. Fernández J. M. Folch R. N. Pena C. Óvilo C. Rodríguez L. Silió A. I. Fernández 《Animal genetics》2012,43(6):805-809
Leptin signalling plays a fundamental role in growth, fatness and body composition. The aim of this study was to investigate the porcine LEP gene sequence in an Iberian × Landrace experimental cross to identify polymorphisms associated with productivity and quality traits. Because of the documented effects on these traits of the LEPR c.1987C>T polymorphism, the LEP and LEPR c.1987C>T polymorphisms and their interactions have been jointly investigated. The LEP gene sequencing has allowed the identification of 39 polymorphisms, eight of which are novel. Three intronic SNPs, LEP g.1382C>T, LEP g.1387C>T and LEP g.1723A>G, have been genotyped, and association analyses have been carried out. Analyses of LEP g.1387C>T, fully linked to LEP g.1382C>T, have revealed additive effects on live and carcass weights and dominant effects on several backfat thickness measurements. Novel effects of both LEP and LEPR polymorphisms on fatty acid composition in subcutaneous fat have been detected, probably mediated through the effects on fatness. The results reported here suggest that the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake. 相似文献
496.
A new technique for the visualization of the cytoskeleton in cultured fibroblasts with Coomassie blue R250 总被引:3,自引:0,他引:3
S D Pena 《Cell biology international reports》1980,4(2):149-153
Staining of fibroblast monolayers with Coomassie brilliant blue R250 provides a relatively easy and fast method for visualization of cytoskeletal elements. Staining of detergent-extracted monolayers improves resolution and provides preparations comparable in definition to those obtained by specific immunofluorescence. 相似文献
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N. H. Fischer G. B. Williamson N. Tanrisever Ana de la Pena J. D. Weidenhamer Elizabeth D. Jordan D. R. Richardson 《Biologia Plantarum》1989,31(6):471-478
The hypothesis that allelochemicals released from members of the Florida scrub community deter the invasion of fire-prone
sandhill grasses was investigated. Constituents of the endemic scrub members, Ceratiola ericoides, Conradina canescens and
Calamintha ashei, were examined for their phytotoxic activity. Effects of the plant natural products on the germination and
radicle growth of lettuce (Lactuca sativa), as well as little bluestem (Schizachyrium scoparium) and green sprangletop (Leptochloa
dubia), two native grasses of the Florida sandhill community, were tested.
The data suggest that ursolic acid and other natural detergents which are released from a source plant enhance the solubilization
of allelopathic lipids via micellization. In general, natural surfactants seem to play a significant role in the water transport
of lipophilic phytotoxins to target seeds or seedlings. 相似文献