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441.
Cynthia M. Getschow Pearl Rivers Samantha Sterman David C. Lumpkin Keith A. Tarvin 《Ethology : formerly Zeitschrift fur Tierpsychologie》2013,119(11):983-992
In habitats in which multiple species are prey to the same predators, individuals can greatly benefit from recognizing information regarding predators that is provided by other species. Past studies have demonstrated that various mammals respond to familiar heterospecific alarm calls, but whether acoustic similarity to a familiar call can prompt a mammal's recognition of an unfamiliar call has yet to be shown. We presented alarm calls to free‐ranging eastern gray squirrels (Sciurus carolinensis) and recorded behavioral changes in vigilance and antipredatory response. Playbacks included alarm calls of a sympatric bird (American robin, Turdus migratorius), an allopatric bird with a call structure similar to that of the robin (common blackbird, Turdus merula), and an allopatric bird with a distinct call structure (New Holland honeyeater, Phylidonyris novaehollandiae). Squirrels responded significantly more frequently to squirrel alarm calls (positive control) than to robin song (negative control) or honeyeater calls. Squirrel response to robin and blackbird alarm calls was statistically similar to their response to squirrel alarm calls, indicating that squirrels responded to those alarm calls as if they provided information about the presence of predators. However, squirrel response to robin song was not statistically different from response to any of the other avian calls, including the robin and blackbird alarms, suggesting that squirrels neither respond to blackbird alarms as if they clearly signify danger, nor as if they clearly do not signify danger, perhaps reflecting some ambiguity in interpretation of the calls. These results suggest that squirrel responses to alarm calls are generally based on call familiarity, but that acoustic similarity of an unfamiliar allopatric call to a familiar call also can elicit antipredator behavior. The lack of response to honeyeater alarm calls also supports the hypothesis that call recognition by gray squirrels is dependent on familiarity, rather than simply detection of an acoustic feature common to alarm calls across a variety of avian species. 相似文献
442.
Anna L. Chambers Laurence H. Pearl Antony W. Oliver Jessica A. Downs 《Nucleic acids research》2013,41(19):9168-9182
Bromo-adjacent homology (BAH) domains are commonly found in chromatin-associated proteins and fall into two classes; Remodels the Structure of Chromatin (RSC)-like or Sir3-like. Although Sir3-like BAH domains bind nucleosomes, the binding partners of RSC-like BAH domains are currently unknown. The Rsc2 subunit of the RSC chromatin remodeling complex contains an RSC-like BAH domain and, like the Sir3-like BAH domains, we find Rsc2 BAH also interacts with nucleosomes. However, unlike Sir3-like BAH domains, we find that Rsc2 BAH can bind to recombinant purified H3 in vitro, suggesting that the mechanism of nucleosome binding is not conserved. To gain insight into the Rsc2 BAH domain, we determined its crystal structure at 2.4 Å resolution. We find that it differs substantially from Sir3-like BAH domains and lacks the motifs in these domains known to be critical for making contacts with histones. We then go on to identify a novel motif in Rsc2 BAH that is critical for efficient H3 binding in vitro and show that mutation of this motif results in defective Rsc2 function in vivo. Moreover, we find this interaction is conserved across Rsc2-related proteins. These data uncover a binding target of the Rsc2 family of BAH domains and identify a novel motif that mediates this interaction. 相似文献
443.
The Mediating Role of Sleep Quality and Quantity in the Link Between Food Insecurity and Obesity Across Race and Ethnicity 下载免费PDF全文
Marie‐Rachelle Narcisse Christopher R. Long Holly Felix Brett Rowland Zoran Bursac Pearl A. McElfish 《Obesity (Silver Spring, Md.)》2018,26(9):1509-1518
Objective
The objective of the study was to examine the mediating role of sleep quality and quantity in the relationship between food insecurity and obesity across races/ethnicities.Methods
Bivariate negative binomial regression and multinomial logistic regression were used to examine direct associations between food insecurity and sleep quality and quantity among non‐Hispanic Native Hawaiian and other Pacific Islanders (NHPI) relative to non‐Hispanic White, Black, Asian, and Hispanic individuals with obesity. The potential outcomes approach and adjusted Wald test were used to explore the mediating role of sleep quality and quantity and the moderating role of race/ethnicity, respectively.Results
Among adults with obesity, the study found a positive and direct relationship between food insecurity and trouble falling asleep in each racial/ethnic group. Trouble staying asleep was associated with food insecurity in each racial/ethnic group, except in the Asian group. Positive and direct associations were observed between food insecurity and short/very short sleep. A positive and direct relationship was found between food insecurity and having obesity in each racial/ethnic group, except in the Black group. Sleep quality and sleep quantity partially mediated the relationship between food insecurity and obesity in non‐Hispanic NHPI, White, Asian, and Hispanic individuals. Race/ethnicity moderated the indirect effects of food insecurity on sleep quality and quantity.Conclusions
Food security and sleep hygiene should be an integral part of the fight against obesity.444.
The objective of this study was to determine if thyroid stimulating hormone (TSH) could induce cumulus expansion in mouse oocytes in-vitro. The effect of TSH was compared with the effects of LH and FSH. Oocytes were incubated in minimum essential medium (MEM) with and without hormones for 16 h at 37 degrees C under a humidified atmosphere of 5% CO(2) and 95% air. Then LH, FSH or TSH was added into the culture medium at a concentration of 0.25, 0.5, or 1.0 mug/ml, respectively. Cumulus expansion was scored in a subjective manner (O = no expansion; + = slight; ++ = moderate; +++ = maximum expansion) 16 h after addition of the hormones. The percentage of oocytes in the 4 categories of expansion was noted; LH failed (P>0.05) to induce cumulus expansion while TSH and FSH induced cumulus expansion (P<0.05) at all of the doses tested. For FSH, the 0.5 mug/ml dose showed the best response (26% = 0; 18% = +; 10% = ++; 46% = +++). For TSH, the 1.0 mug/ml dose showed the best response (38% = 0; 18% = +; 13% = ++; 31% = +++). 相似文献
445.
C. -C. Sung R. Collins J. Li D. K. Pearl Stephen W. Coons Bernd W. Scheithauer Peter C. Johnson A. J. Yates 《Glycoconjugate journal》1996,13(3):433-443
We studied myelin proteins and glycolipids in 24 human oligodendrogliomas (16 pure, eight mixed), including two grade I, 13 grade II, five grade III, and four grade IV Tumours with a 1b ganglioside content (GD1b, GT1b and GQ1b) over 30% of total gangliosides occur more frequently in the WHO grade I II and (47%) and grade III (40%) than in the grade IV (25%) group; there was no difference in the amounts of total ganglioside or individual gangliosides between pure and mixed oligodendrogliomas. The presence of 6-LM1 correlated with higher grades of tumours (2
p0.02); however, 3-LM1 and total neolacto-series gangliosides did not correlate with grade. Immunohistochemical studies of oligodendrocyte and myelin markers (GalCer, sulfatide, 2,3-cyclic nucleotide phosphodiesterase, myelin basic protein and proteolipid protein) using specific antibodies showed only a very small proportion of tumour cells staining. These data do not support the hypothesis that tumours classified as oligodendrogliomas are derived from mature oligodendrocytes. 相似文献
446.
447.
Joshua D. Ochocki Sanika Khare Markus Hess Daniel Ackerman Bo Qiu Jennie I. Daisak Andrew J. Worth Nan Lin Pearl Lee Hong Xie Bo Li Bradley Wubbenhorst Tobi G. Maguire Katherine L. Nathanson James C. Alwine Ian A. Blair Itzhak Nissim Brian Keith M. Celeste Simon 《Cell metabolism》2018,27(6):1263-1280.e6
448.
Tumour growth is dependent on multiple factors, including the physiological process of angiogenesis. Several opportunities for inhibiting angiogenesis with targeted therapies have been identified and are currently being evaluated for clinical efficacy. Some of the most promising approaches include small-molecule inhibitors for the tyrosine receptor kinase VEGFR2. Other signal-transduction pathways have also been shown to regulate angiogenesis, including FGFR, PDGFR, Tie and EphB. 相似文献
449.
Abstract: Several new taxa of snakeflies (Raphidioptera) are described from the Lower Cretaceous deposits of the Wealden, UK (Barremian), Montsec, Spain (Barremian) and the Crato Formation, Brazil (Aptian). Mesoraphidia ednae sp. nov. and M. hilli sp. nov. are described from the Wealden; Nanoraphidia lithographica sp. nov. and Iberoraphidia dividua gen. et sp. nov. are described from Montsec, and Baissoptera lisae sp. nov. is described from the Crato Formation. The geographical range of Nanoraphidia has potentially been extended. 相似文献
450.