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排序方式: 共有550条查询结果,搜索用时 15 毫秒
431.
Joshua D. Ochocki Sanika Khare Markus Hess Daniel Ackerman Bo Qiu Jennie I. Daisak Andrew J. Worth Nan Lin Pearl Lee Hong Xie Bo Li Bradley Wubbenhorst Tobi G. Maguire Katherine L. Nathanson James C. Alwine Ian A. Blair Itzhak Nissim Brian Keith M. Celeste Simon 《Cell metabolism》2018,27(6):1263-1280.e6
432.
Tumour growth is dependent on multiple factors, including the physiological process of angiogenesis. Several opportunities for inhibiting angiogenesis with targeted therapies have been identified and are currently being evaluated for clinical efficacy. Some of the most promising approaches include small-molecule inhibitors for the tyrosine receptor kinase VEGFR2. Other signal-transduction pathways have also been shown to regulate angiogenesis, including FGFR, PDGFR, Tie and EphB. 相似文献
433.
S Ceschini A Keeley M S McAlister M Oram J Phelan L H Pearl I R Tsaneva T E Barrett 《The EMBO journal》2001,20(23):6601-6611
Resolution of Holliday junctions into separate DNA duplexes requires enzymatic cleavage of an equivalent strand from each contributing duplex at or close to the point of strand exchange. Diverse Holliday junction-resolving enzymes have been identified in bacteria, bacteriophages, archaea and pox viruses, but the only eukaryotic examples identified so far are those from fungal mitochondria. We have now determined the crystal structure of Ydc2 (also known as SpCce1), a Holliday junction resolvase from the fission yeast Schizosaccharomyces pombe that is involved in the maintenance of mitochondrial DNA. This first structure of a eukaryotic Holliday junction resolvase confirms a distant evolutionary relationship to the bacterial RuvC family, but reveals structural features which are unique to the eukaryotic enzymes. Detailed analysis of the dimeric structure suggests mechanisms for junction isomerization and communication between the two active sites, and together with site-directed mutagenesis identifies residues involved in catalysis. 相似文献
434.
JÖRG MALETZ 《Palaeontology》2005,48(4):763-780
Abstract: Early Middle Ordovician graptolites from the Albjära and Lovisefred drill cores (Scania, southern Sweden) can be differentiated into the Isograptus victoriae , Isograptus sp. nov. 2 and Maeandrograptus schmalenseei , Arienigraptus dumosus type/ Pseudisograptus manubriatus biozones of Castlemainian and Yapeenian age and the Arienigraptus zhejiangensis and Undulograptus sinicus biozones of early Darriwilian age, replacing the old, long-ranging Didymograptus hirundo Biozone. Faunas from the drill cores include a number of species not previously recognized in Scandinavia. 相似文献
435.
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437.
Hassler M Singh S Yue WW Luczynski M Lakbir R Sanchez-Sanchez F Bader T Pearl LH Mittnacht S 《Molecular cell》2007,28(3):371-385
The retinoblastoma susceptibility protein, Rb, has a key role in regulating cell-cycle progression via interactions involving the central "pocket" and C-terminal regions. While the N-terminal domain of Rb is dispensable for this function, it is nonetheless strongly conserved and harbors missense mutations found in hereditary retinoblastoma, indicating that disruption of its function is oncogenic. The crystal structure of the Rb N-terminal domain (RbN), reveals a globular entity formed by two rigidly connected cyclin-like folds. The similarity of RbN to the A and B boxes of the Rb pocket domain suggests that Rb evolved through domain duplication. Structural and functional analysis provides insight into oncogenicity of mutations in RbN and identifies a unique phosphorylation-regulated site of protein interaction. Additionally, this analysis suggests a coherent conformation for the Rb holoprotein in which RbN and pocket domains directly interact, and which can be modulated through ligand binding and possibly Rb phosphorylation. 相似文献
438.
Jenn M Croke Luke RG Pike Daniel J MacPhee 《Reproductive biology and endocrinology : RB&E》2007,5(1):22
Background
Myometrial growth and remodeling of the cytoskeleton and focal adhesions during late pregnancy may be critical aspects of myometrial activation and thus labour. Yet our understanding of these aspects is inhibited by the paucity of information concerning the components of focal adhesions in the myometrium. The focal adhesion protein hydrogen peroxide-inducible clone-5 (Hic-5) has recently been found in mononuclear smooth muscle but was not examined in the myometrium during pregnancy. Thus, the goal of this study was to characterize Hic-5 mRNA and protein expression in the rat myometrium during pregnancy and labour. 相似文献439.
Iskovich S Kaminitz A Yafe MP Mizrahi K Stein J Yaniv I Askenasy N 《Current stem cell research & therapy》2007,2(4):272-279
Regenerative medicine opens new avenues and promises towards more effective therapies for autoimmune disorders. Current therapeutic strategies for type I diabetes focus on three major directions, with distinct advantages and disadvantages: arrest of autoimmunity, islet transplantation and generation of neoislets. There is mounting evidence that candidate stem cells residing in the hematopoietic compartments participate in regeneration of pancreatic islets following chemical and autoimmune injury in vivo. The apparent major mechanisms include immunomodulation, revascularization, support of endogenous beta-cell regeneration and differentiation into insulin-producing cells. Review of the current evidence suggests that some divergent observations depend primarily on the experimental design, which both limits and accentuates developmental events. The flood of publications reporting negative results appears to reflect primarily suboptimal experimental conditions for differentiation of putative stem cells, rather than limited developmental plasticity. Stem cells modulate the course of autoimmune diabetes through multiple mechanisms, including de novo generation of units capable to sense, produce and secrete insulin. Therefore, the charged debate over controversies surrounding developmental plasticity should not impede attempts to design curative therapies for this disease. 相似文献
440.