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排序方式: 共有253条查询结果,搜索用时 46 毫秒
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S.P. Govindwar M.S. Kachole S.S. Pawar 《Biochimica et Biophysica Acta (BBA)/General Subjects》1983,756(2):191-195
Cytochrome P-450 substrate interactions were studied with cytochrome P-450 partially purified from livers of untreated, phenobarbital-treated, benzo[a]pyrene-treated and caffeine-treated rats. Partial inhibition of aminopyrine N-demethylase in presence of in vitro caffeine observed with intact microsomes was further investigated in a reconstituted system composed of partially purified cytochrome c reductase. Caffeine addition (in vitro) to partially purified cytochrome P-450 altered the hexobarbital, aniline and ethylisocyanide induced spectral change, and decreased NADPH oxidation in presence of substrates aminopyrine and acetanilide. NADPH oxidation was found to be increased in presence of aminopyrine and unaltered in presence of acetanilide in reconstituted system having partially purified cytochrome P-450 from caffeine-treated rats. Our studies suggest that caffeine acts as a true modifier of cytochrome P-450 and is possibly responsible for the formation of abortive complexes with aminopyrine. 相似文献
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Shaligram Shraddha Kumbhare Shreyas V. Dhotre Dhiraj P. Muddeshwar Manohar G. Kapley Atya Joseph Neetha Purohit Hemant J. Shouche Yogesh S. Pawar Shrikant P. 《Functional & integrative genomics》2017,17(1):119-119
Functional & Integrative Genomics - 相似文献
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Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored. Here, we report 5′-tRNA half molecules as abundant activators of TLR7. Mycobacterial infection and accompanying surface TLR activation up-regulate the expression of 5′-tRNA half molecules in human monocyte-derived macrophages (HMDMs). The abundant accumulation of 5′-tRNA halves also occur in HMDM-secreted extracellular vehicles (EVs); the abundance of EV-5′-tRNAHisGUG half molecules is >200-fold higher than that of the most abundant EV-microRNA (miRNA). Sequence identification of the 5′-tRNA halves using cP-RNA-seq revealed abundant and selective packaging of specific 5′-tRNA half species into EVs. The EV-5′-tRNAHisGUG half was experimentally demonstrated to be delivered into endosomes in recipient cells and to activate endosomal TLR7. Up-regulation of the 5′-tRNA half molecules was also observed in the plasma of patients infected with Mycobacterium tuberculosis. These results unveil a novel tRNA-engaged pathway in the innate immune response and assign the role of “immune activators” to 5′-tRNA half molecules.Although Toll-like receptors (TLRs) play a crucial role in the innate immune response, their endogenous ligands have not been fully explored. This study identifies tRNA half-molecules as abundant TLR ligands which are upregulated upon infection by mycobacteria and activate TLR7. 相似文献
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Long-term treatment with angiotensin-converting enzyme inhibitors reduces post-infarction morbidity and mortality in patients
with left ventricular (LV) systolic dysfunction or symptomatic heart failure. Until recently, the effect of such treatment
in patients with preserved LV function has not been known. The results from the Heart Outcome Prevention Evaluation trial
have indicated that long-term treatment with ramipril leads to a significant reduction in cardiovascular events in patients
with atherosclerotic disease, including those with prior myocardial infarction and preserved LV function. These results suggest
that long-term angiotensin-converting enzyme inhibition should also be considered in post-infarction patients with normal
cardiac function. 相似文献
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